Rodents and Red Wine with Maria Konnikova

00:00:15
Speaker 1: Bushkin love that you're wearing a T shirt that says Canada, just so that we have no ambiguity whatsoever.

00:00:27
Speaker 2: Where are you right now? You in Las Vegas?

00:00:32
Speaker 1: I'm in Vegas right now. Yeah, I just got back here two days ago.

00:00:37
Speaker 2: Nice, very nice? Did I tell you? You know that? I was in Las Vegas and I had an afternoon and I sat in this coffee shop and there were three people next to me having the most interesting conversation. And one of the guys started talking and I realized he was talking about you.

00:00:57
Speaker 1: Really.

00:00:58
Speaker 2: Yeah, he was a lawyer of some kind who like, was a writer, lawyer or something. I don't know. I couldn't figure it out. And I was eavesdropping in a conversation for like, and it was like the most interesting conversation.

00:01:13
Speaker 1: I love that story. Now you did not tell me, and I have no idea who you're talking about.

00:01:20
Speaker 2: Allow me to introduce a new voice to this podcast, Maria Kanakhova. In basketball, they call people like Maria Swiss army knives, people who do everything. Maria got a PhD with the famous Walter Michelle, the guy who invented the marshmallow test. She's written a bunch of brilliant New York Times bestsellers. She decided at one point that she was interested in poker, taught herself poker, became a poker champion, made some enormous sum of money. She's the kind of person that random strangers talk about in coffee shops, which is to say, my kind of person. I'm Malcolm Gladwell. You're listening to Revisionist History, my podcast about things overlooked and misunderstand, and I have the pleasure in this episode to bring you the fabulous Maria Konikova, who has agreed to become the first ever Revisionist History amistman, or rather honest person. She is joining the show to be the advocate for you, dear listener, to call me on my nonsense, to be a voice of reason, to participate in the kind of whimsical, meandering flights of intellectual fancy that is our trademark here at Pushkin Headquarters. So Maria, welcome to Vision's History. I could think of no one better equipped to speak truth to the power that is Revision's History.

00:02:49
Speaker 1: Thanks so much for having me on the show, Malcolm. I'm very excited about this. You know, maybe you'll change my mind maybe I'll change yours, but I think that the conversation is going to be very entertaining no matter what.

00:03:02
Speaker 2: Wonderful let's have at it. I am putting in your hands. Is that correct?

00:03:08
Speaker 1: Nice putty that's responsive and that talks back?

00:03:13
Speaker 2: Okay, you're driving this train, all right?

00:03:16
Speaker 1: Perfect. So one of the fascinating episodes of this season of Revisionist History was about the lack of iodine in people's diets and how this was discovered and how it was actually then addressed and had I actually did not know the story at all. It's such a fascinating question. You know, how do we think about these things in the present day? Would we be able to do something like this today, you know, especially like after COVID, after all of these things like add iodine to their salt or their water and see what happens. What do you think the response to something like that would be.

00:03:54
Speaker 2: Well, you know, it's interesting that there is a line, there's a common line of either complaint or congratulation among sciences where they say that experiment could never be done today. The Stanford's Prison experiment could never be done today. Then the Tuskegee siftless experiment could never be done. You know, there's a whole long list of things. They look at that, and they say, and that's because we are much more mindful of people's autonomy, much better about obtaining consent. You totally today could not go to Akron and dose up a bunch of schoolgirls with a ton of eyeein. However, my reaction to that argument is always the same, which is, yeah, but we simultaneously conduct consentless experiments on human beings in the present day that are probably way more consequential, and we don't think twice about it. You know, think about the way we have disrupted the lives of I don't know children over the last twenty five years, with all of these new technologies. How's that not a massive experiment done without the consent of those who were experimented on. How is the Facebook algorithm, which you know shows you only the things that are likely to evoke a deeply emotional response in you. How's it not an experiment? I mean, there's a part of me that just wants to throw out my hands and say, you know, efort, well, it's not even let's not even let's not even bother making these distinctions. Once we've conceded that all these experiments can go on. Let's just declare them experiments and let people pick and choose the one they want to be a part of.

00:05:38
Speaker 1: I think there's something to that, especially because you know, at least with the iodine, right, it was there was scientific evidence for the test, right, There was a reason why they did it. There was a huge body of evidence behind this, and the study was run as a study, and so there were scientific controls in place. You know, they actually could gather data, whereas with a lot of these other things, you know, it becomes a natural experiment, which is obviously MESSI has a lot of unintended consequences, and I mean there are a lot of different questions there. I'm actually curious about flipping it around where you have something like fluoride, right, which is another additive that's put in our water. And last year, I don't know if you were following this, but in a town in Vermont, it turned out that a town official for over a decade had been lowering fluoride levels below the accepted minimums because he thought that it was a government conspiracy. You know, fluoride in your water bad. And he resigned and it was a big outrage, and everyone was outraged that their water wasn't being properly fluoridated, that they actually weren't getting the numbers that they needed for dental health, cavities, et cetera. I just did think that it was such an interesting counterpoint because normally it's, oh, don't add anything, right, I don't want anything at it that I don't know about. I want natural salt, I want natural water. I don't want you adding anything, you know, big pharma, big government, big big, et cetera. And here the town was actually horrified, which I think they should have been.

00:07:18
Speaker 3: You know, I'm biased, you know, I think there's good evidence that adding Florida to water is a good thing, that adding I had dined to salt is a good thing, and that when things are good.

00:07:29
Speaker 1: For our health and we're not going to get them in any other way, that this is a great way of doing it. But a lot of people disagree.

00:07:35
Speaker 2: Well, I wonder, you know, if that are they responding to the Florida They responding to what they see as as the official abusing his position, right, you can you know it's it's it's maybe it's a bit of both, or you know, you could see people who might ordinarily be indifferent to fluoride just getting pissed off over this issue. This guy's like, you're not allowed to do that, sir. Hold on, hold on, it's time for a short break. When we come back, we'll talk more about how salt and revision is history are changing lives, and also the infamous Minnesota starvation study.

00:08:25
Speaker 1: So let's read a letter about someone from someone who I actually I love this letter. I just saw it today and it is a very positive take on additions to food and someone who says that, you know, the Salt episode actually really changed their life. So this is from Mary P. And she writes that it was a crazy, awesome coincidence that I was listening to this episode around the same time my doctor felt a nodule on my thyroid. He told me to go get an ultrasound, and my thyroid and nodule both were large enough and suspicious enough that it was recommended automatically that I get a biopsy. So she went for her first biopsy and the results came back in conclusive. And I'm going to continue reading her letter. They sent another side for genetic texting. Meanwhile, I bought some iodized salt and started cooking with it. I had switched to kosher salt and other fancy salts over the past few years, and I'm an avid at home cook. We also live in the Midwest. I used iodized salt in moderation, of course, and thought nothing more of it. Well, I went back for my biopsy and they took new ultrasound images of my thyroid. This was about two to three months after my original ultrasounds. In biopsies, the ultrasound tech was asking me many questions and seemed confused, but kept to himself. The doctor came in and told me to sit up. My nodules and thyroids had all shrunk. My once once sentime to nodule was now around five millimeters. He had no reason to biopsy because there was nothing of concern. In fact, he would not biopsy it, no surgery, just a follow up scan in a year Hallalujah. I told him my theory about the iodine and he said that very well could have been what shrunk everything. I asked if the cancer could be in there, just smaller. He scoffed at me and said no.

00:10:19
Speaker 2: What a great letter, right, Wow, for all of those who doubt the healing power of Revision's history. I present you this letter. We don't we don't just we don't just rile up our listeners. We save lives. This is a resounding endorsement of years of Revision's history.

00:10:38
Speaker 1: And those types of coincidences are great. Right, that you hear something and it actually has such an impact that would have been a life changing thing for her to have no thyroid function, half her thyroid function for the rest of our life, that's a huge thing.

00:10:51
Speaker 2: Yeah, you know, it's a reminder. This is one of these weird things, like one hundred years ago, what she's describing was commonplace. In fact, this is a little little fact in that episode that I can never get over my head is if you went to parts of the world that were iodine to fish and some extraordinarily high percentage of the population had these massive goiters on their neck, and like that was just part of the part of the experience of going to the Swiss Alps, or part of the experience of going to somewhere around the Great Lakes was you'd walk into a small town and you know whatever, quote of the people had big grapefruit sized masses on their necks. It's just so strange.

00:11:35
Speaker 1: It's crazy how little we still know about nutrition. Right. Nutrition is complicated, and I think that's one of the reasons why people still have, you know, so many questions, so many issues, why we go back and forth with nutritional advice, because the body is a complex thing, right, It's a complex machine, and it's so it's very difficult oftentimes to know like this is the recommendation and it will always be the recommendation.

00:12:00
Speaker 2: And also, you know, it's hard. This is sort of what brings us to the miss starvation experiment, which I'm sure we're going to talk about. But one of the big impetuses for that is that one of the reasons we know so little about nutrition is that it's impossible to test hypotheses about nutrition, because how do you do it right, Like, if you think about something as simple as does drinking alcohol harm or help your health? Right, that's a question that's been irrelevant for as long as human beings have drunk alcohol, So thousands and thousands and thousands of years, we're still arguing about that. And the reason we're still arguing about it is it's virtually impossible to design a study which would satisfactorily answer that question. So there happens that which say people who drink wine and moderation seem to live long, healthy lives. But you know, the problem is that people who drink wine in moderation are people who otherwise live moderate, healthy lives. Right, They're like, you know, they're villagers in the south of Italy who are getting in enormous amount of exercise and living in bucolics surroundings. So you just don't know is it is. Are are they living long, happy lives in spite of their one consumption or because of it? Right simontanoing you know you see these so you can read. It's just incredibly I just read read the other day, like there's a new line of thinking which says, you know, all alcohol is basically like really bad for you and should be avoided.

00:13:33
Speaker 1: I saw that.

00:13:34
Speaker 2: I have no idea what to make of that, Like, I don't even know how do they manage that conclusion. It's just that that idea that we could be in twenty twenty three and still being capable of answering these questions with any degree of accuracy is fascinating to me.

00:13:47
Speaker 1: Yeah, it's totally crazy. It's so funny that you mentioned red wine, which is you know, or alcohol in general. The first one of the first studies I ever worked on as a journalist who who kind of is interested in these questions forever ago, was on resveratrol when it first came out, like the data that, oh my god, res vitrol makes you live longer, and everyone was saying, great, red wine, it's amazing. Then a few years later we find out that the quantity of versviatrol you need is just so much higher than you would ever get. And it goes back and forth, and I've seen that one question just go in circles for you know, almost twenty years now, and we we just have no idea.

00:14:29
Speaker 2: Do you remember was it were they Were they getting rats large doses of.

00:14:33
Speaker 1: Yes, Oh, that's the thing, exactly, That was exactly it. It was rodents, rodence, and red wine.

00:14:39
Speaker 2: So the only the only thing we can say for certain is that within the rat population, those who enjoy a good bottle of wine every night are going to live a little longer.

00:14:48
Speaker 1: So I think that this is a good a good segue point. You know, people who were not drinking any wine were taking part in the starvation study, that was part of this season of revisionist history. So I mean, first of all that study, let's just kind of recap it very quickly. I mean we're talking actual starvation, like the number of calories that these men. So it was all men. It was all young, relatively healthy men who were, for one reason or another, not in the military, not serving abroad during World War two, and they were all brought to this place to try to control because as we've just talked about, it's really difficult to control food intake, to try to control it as much as possible, to try to do their part for the war effort to see how starvation affects the body. Is that a fair summar.

00:15:44
Speaker 2: Race, Yes, exactly, because you don't already had The impetus was this was in the middle of the war, and the feeling was that by the end of the war one of the biggest problems the world was going to face was that millions of people around the world had suffered prolonged malnutrition throughout the conflict, and we didn't know how to help them. We honestly had no idea if someone has been malnourished for a year and a half, what is the best way to nurse them back to health and literally we hit people. At the time didn't have the size clue, right, So they were trying to answer that question with some at least get some information about that. So there was the stakes here were huge. I mean, that's what gives the study, it's kind of moral force.

00:16:35
Speaker 1: So that's an interesting question, right, does the study have the necessary moral force to do something like this, because when back in the day, right back when this study was done World War Two, we didn't have the sort of reviews on studies that we have today. So these days you need to go through an i RB, which is an institutional review board when you're doing any sort of human research, and you need to have every single subject give informed consent. And this is crucial. The benefits of this specific study have to outweigh and potential harm to the participants in the study. And so to me, you know, when I listened to kind of the details of the starvation experiment, I knew that it existed, but I actually didn't I'd never actually kind of gone deep into it. This was the most I'd learned about it was from you. And as I was listening, I was trying to think, you know, first of all, benefits versus harm. You know, how do we think about that? And I think that's actually changed over the years. But the second part of it is how do you actually give informed consent of all the potential downsides to something like this when you're researching something where you don't actually know what the potential downsides are.

00:17:57
Speaker 2: Well, it's like spaceflight. You're sending an astronaut to the moon. Presumably you pull the astronaut aside beforehand and you say the benefit year is mankind will be able to say we went to the moon. But you know, in that situation, the first astronaut in space, we don't know what it's like to be out for a couple weeks in zero gravity. So I don't know how do they do consent. I guess they said, you're taking a risk of unknown quantity, you might be damaged by what you're doing. Are you fine with that? And I think the answer they were fine with it is that many of those astronauts came out of the military, and so they were used to the idea that they were called to do something on behalf of their country, which carried with it a significant risk of illness and death.

00:18:53
Speaker 1: I think That's an interesting example, but it's not a complete analogy, because this was their profession, right, this was their career, this is what they had signed up for. They became astronauts with the knowledge that they would hopefully be able to go into space one day. Whereas these study participants were just ordinary men who were called upon by their patriotic feelings and said, you know, do you want to do your patriotic duty. That's a lot of pressure, and that's not your life. This is not something that's your career. You're being asked to do something that's just totally out of the ordinary.

00:19:24
Speaker 2: Wait, you are you? Are you a Minnesota's starvation experiment skeptic? Do you not think it should have been done? No?

00:19:32
Speaker 1: I'm someone who wants to push back though, and to question how it was done and whether they could potentially have ever given and formed consent to something like this, especially given what we know now about the long, longitudinal, long term effects about starvation. Back then, the term epigenetic I don't think even existed. People did not know kind of what the interaction of genes and environment is. Today, we actually know that starvation has lifelong consequences. They actually change the methylation patterns of your of your genes, of your genome, and that there's actually a lot of damage that is going to be done for your entire life. And the funny thing is a lot of the data, the best data that we have on this didn't come from the starvation experiment, but actually happened from a natural experiment that came at the exact same time, more or less contemporaneous, which was basically the Dutch hunger winter. It was also during World War Two there was a huge famine in the Netherlands because there was a blockade by the Nazis and thousands of people died. I think something like twenty thousand people ended up dying. But at the same time, there were a bunch of women who were pregnant and doctors were taking all of the measurements that you would normally take during pregnancy, but these women happened to be starving, and then they ended up following the women and the babies for their lives and actually got an amazing amount of data on what starvation does to the body.

00:21:14
Speaker 2: What does it do?

00:21:15
Speaker 1: Oh well, we're still finding out. There are lots of things that end up happening later in life. You're more prone to gain weight because your body is prepared for starvation and has been prepared for from in utero. It also ends up, you know, affecting your the way that your kids are going to develop. So if you were, I guess, a fetus during during this time, then by the time that you're you're an adult, when you have your own kids, you're actually going to pass a lot of these epigenetic changes further on to them. They are also going to be effects on how you're going to just think and do in life. It turns out that there are labor market effects, hospitalization effects, so you know, it actually puts you down a notch. But this is once again we're talking about the people who were who were fetuses during this time, which is very different from the starvation study, but it ends up having a lot of downstream effects, and those studies are still being done. So there are you know, there's a new paper at least once every few years using this cohort which shows that you know, you didn't there are lots of things that you didn't know you were signing up for. If you thought that this was just going to be an easy you know, I starve myself completely and then I'm all better and this will never actually follow me throughout life. And it's interesting to me that I think some of our best data comes from a natural experiment, as opposed to something where a bunch of men said, okay, starve me and let's see what happens.

00:22:56
Speaker 2: So imagine that we were doing a version of the Dutch starvation thing involving pregnant women. But it was an experiment, right.

00:23:07
Speaker 1: All right, magic wandftly measure.

00:23:10
Speaker 2: And what we learned from that is that actually starving people when they're pregnant has incredible as unanticipated long term consequences not just for the mother but for the child and even maybe for the child's children child.

00:23:27
Speaker 1: So absolutely so.

00:23:29
Speaker 2: In other words, and we had no idea of this before. So this is a kind of like, this is a this is a earth shattering, huge bit of understanding about human beings. Why wouldn't this be an argument. Why wouldn't the magnitude of what we learned from that such an experiment be an argument for doing the experiment?

00:23:53
Speaker 1: Not?

00:23:53
Speaker 2: Right, It's so important that hundreds thousands, millions more people could be helped from the knowledge gleaned from that experiment than those who were who were harmed by it, And if the people who signed up for that experien had a at least a kind of reasonable suspicion that what was learned from the from them putting themselves at risk might help many, many, many, many many more people, then to my mind, that settles it. It's fine. I mean, this is what I was trying to get to in the podcast, is that we're so indifferent to people who have altruistic motives. That isn't where is the altruistic motive data point in the consent algorithm? Like you should be able to say, I know it's going to harm me, but I think it's going to help a lot more people, and I'm fine with that.

00:24:47
Speaker 1: Yeah. So, like I said, when you asked me, am I a skeptic of this? I said, I'm not necessarily someone who said this shouldn't have happened. I just think that, you know, there are lots of issues to consider. So, yeah, there is this. There's definitely an argument to be made that, you know, what we learned from Dutch famine shows that studies like this are incredibly important. But in this particular case, right, I think in the pregnancy case, you're also giving consent for your fetus. Right, So it's one of these things where that's even if you're an altruist, I think that that would be a very strange definition of altruism, because you're being altruistic for the world, but not for this one specific human who has no say in this whatsoever.

00:25:32
Speaker 2: But I would say this like so, for much of human history, continue to the present day, a large percentage of the world's population suffers from prolonged malnutritionolutely, So one really important historical question is what can we do to convince the wealthier parts of the world that this is such an urgent problem that it needs to be addressed immediately. Right, wouldn't it make sense to try an extreme experiment of this sort to try and bring the world around?

00:26:09
Speaker 1: I mean, I think I think that's a very valid point. And you actually had a letter from a listener, Robert A, who asked a question that kind of circles around what we've been talking about. He asks, who is responsible for a system which both restricts voluntary breakthrough research like that conducted by Ansel Keys and the conscientious Objectors, and that which fails to take accountability when mistakes are made? So there's a that's I think an interesting question because you do have those two sides of it. So we do have a system that now does restrict that kind of breakthrough research quite often. I mean, when I was in grad school for psychology and I needed to do an experiment that had deception, I just I couldn't get it approved. I had to jump through so many hoops, and eventually, you know, with the support of all the senior faculty in the psychology department, it was just this silly thing. It wasn't even a major deception study, but we needed We couldn't tell them that we were studying self control, right, because that would actually have defeated the purpose of the entire study. And how many studies are not done because of that. So that's kind of the one side of it. But on the other hand, there's a reason for all of these safeguards because you have things like the Stanford person experiment, right, you have things like Tuskegee. You have things that really crossed the line without informed consent, with deception, with a lack of understanding of what was going to happen. I mean, one nutrition study that was done, I don't know if you remember this one, but it was done in Washington on some young men who were working, you know, around DC at the time, and they were basically they agreed to be poisoned. They went to the Congressional cafeteria in their diet was very strictly controlled and they were just trying to figure out how different food additives work. And some of them got incredibly sick because it turns out that they were eating very toxic amounts of things they should not have been eating. So that was that was a study gone a bit off the off the rails when it comes to nutrition. But so you have those two extremes and how do you how do you weigh that, how do you balance that? How do you not in retrospect where we can say, Okay, you know this is what we learned from this study and it was really good, but before it happens, how do we how do we think about that? How do we kind of how do we walk that line?

00:28:36
Speaker 2: Yeah, I will say that there is there is one area on this where I am I'm the you know, I've been talking so far about how I would I tend to be pretty laissez faire about giving researchers the freedom to do things that are a little bit risky. Or there's another area though, where I'm on the exact opposite side of the fence, And what am I referring to, patience, grasshopper? When we come back more from my conversation with Maria Konakova, we're back, and I was telling Maria that I'm pretty laissez fair about letting experiments go forward, except in the case of what might be the most awful natural experiment we're living through right now. I am incredulous at the idea that thousands of pages of text and hours of argumentation is spent on the ethics of one medical experiment or another. And at the same time we are, you know, completely indifferent or cavalier about the levels of violence that are present in media every day. Now, there had been moments every now and again, periodically there are moments where various interest groups get upset about depictions of violence on television. Was a big deal I think in the seventies, for example, and then it sort of went away, and then the people who were complained about this got painted as kind of buffoons or as naive sewer in the middle of nowhere. And you know, I don't want to give it away, but I had in the course of an episode of I'm Doing in this upcoming season where I have these long conversations with trauma surgeons who deal with gunshot wounds, and what they have to say on this very specific matter is incredibly interesting and disturbing. They're They're not like hiding their head in the sand about this. They are fully aware of it. The people who are who have a I believe a morally objectionable position, or the people in Hollywood, many of whom are self described liberals, who will go on and on and on about the you know, the terror need for gun control in America and how outrageous all the Second Amendment people is. And meanwhile they're making movies well like twenty people are slaughtered in the first fifteen minutes. Like, I'm sorry, this is just like completely incomprehensible behavior, right. This drives me nuts.

00:31:27
Speaker 1: Yeah, I know that there's a lot to be said for that. It's like we've never outlived the instinct for public executions right where everyone would come to the town square. Instinct is still alive and well, it's an important tangent to go on, and it is related to everything we've been talking about about how do you study this? You know, what are the benefits, what are the harms? And there's you so kind of coming full circle back to the starvation experiment, there is one thing that we haven't talked about, which was an important point that one of the listeners brought up. And this is an important point about a lot of the research not from that day, but that continues to be done to this day, which is how realizable are the results to the segments of the population that might actually benefit most from it. So Maura, this listener wrote, how can we treat eating disorder patients primarily young women using data collected exclusively on white men. How can we use this to study the impact of dieting and weight loss when dining is more prevalent and pressured upon among women. How can we use this to study obesity when non Hispanic black adults and Hispanic adults have the highest prevalence of obesity in the United States. That's the end of her letter, But I would just go on and on. When we're talking about malnourishment and we realize that most of the malnourished population of the world is not white men, So that is kind of an interesting side note, and this is actually still a huge problem. That's not something that we left behind in the forties. To this day, most medical data comes from men, not women, and it's a very kind of that's an interesting way of looking at you what are the actual benefits from us to the people who need them, and how general of isable is.

00:33:12
Speaker 2: If you're trying to develop actionable policies and guidelines and approaches to affective populations, it absolutely does matter. And you know, we went through this with I think with our understanding of heart attacks right where we started off testing a lot of these hypotheses in men, white men, and that's how we got our baseline knowledge. But then we tried to use that information to kind of understand how to deal with women without realizing that the biology of a lot of these problems, physiology of a lot of these problems in women's very different. So I think it depends where you are in the kind of stage that you're at. And the mistake we make, I think is we don't honor this distinction between kind of basic understanding and actionable research. If you talk to somebody body who is works for a pharmaceutical company and is involved in drug trials. You know, they will talk your ear off on this, and what they will say is, do you know how hard it is to put together a study population. It's insanely difficult to find someone. I actually thought of I was going to volunteer for a trial about lime disease vaccine. And then I add that the first thing to do is you have half an hour conversation with someone. And they detail that I would have to go to drive to Albany an hour away, seven times and have to set aside half a day on each of those occasions. And I wasn't clear whether I'd be part of the treatment group or the pacibo group, right, So I listened to that. I was like, I can't do that. I'm not taking you know, somewhat selfishly, I decided I don't have that much time to devote to this, so I'll let someone else carry the burden. So it's like, it's really hard to do these studies. So when you if we say these studies have to be perfectly representative, you're just making it less likely that the study gets done in the first place at a certain point. Right, So that's the trade off. It's an impossible trade off.

00:35:14
Speaker 1: Sure, No, I think, I think there's a lot of truth to that. That said, I do think that even baseline knowledge studies these days should at least include women because you know, if you're omitting more than half the population and the basic biology is different, then but.

00:35:28
Speaker 2: You couldn't have done the starvation experiment with women.

00:35:32
Speaker 1: So that's the other thing, right, what are we proposing in the starvation case? Do we want women there? And Hispanic and black where it's much more difficult to actually obtain consent because especially back then, but even to this day, you know, these are populations that have had a lot of negative research done without consent, and it's actually much more difficult, I would say, and the burden of proof is much higher to ask for consent from vulnerable population.

00:36:03
Speaker 2: You can't do a starvation experiment like that in Minnesota on young women because if it has consequences for their fertility than you have So what are you going to see? Does so are we going to use are we going to use postmen apausal women only? But that brings up a whole different set of issues because now you have an older population that's going to be less susceptible to whatever risks you're exposing them to it's tricky. This reminds me we talk in the season about magic wands experiments we could do if we could wave a magic wand this one doesn't actually you require a magic wand, although it would be very hard to do in the real world. But you mentioned that natural experiment in Holland which gave us information that would have been almost impossible to get otherwise in a formal experiment. And it goes to the larger point that this is the great thing about natural experiments is that when you can find a good one, they almost invariably tell you stuff that you could never find out other way. They're incredibly productive kind of experiment. So why can't we engineer actual experiments? So imagine this. Imagine if someone came to you and me and a million other people and said, we're at the stage now in our in technology where we can put little sensors on you which can continuously monitor every one of your physiological signs and vital signs in real time. Would you agree to be basically monitored for the next whatever ten years and you and two million or ten million other people agree to be part of this, and we will we will simply wait and see what happens to you and use that massive data set to kind of improve our understanding of the kinds of things that lead to various sorts of diseases. I mean, if you had ten million people and they were giving you ten years of their life and every conceivable indicator and vital sign was being monitored on a moment to moment basis, you would be able to understand stuff that right now we have no clue about, right and all it takes is for people just they don't even take in a risk, They're just being willing to be monitored and donate their data. That's essentially engineering a natural experiment. I don't understand why that hasn't been done. Privacy, no one who cares this is don't even me started on privacy. Privacy drives me just nuts. It's like, what an absurd thing in this day and age to be concerned about. Like, basically, as far as I can tell, every single fact about Malcolm Glovel is known by like some combination of Facebook, Apple, Google and someone else.

00:38:52
Speaker 1: And so I meant to ask, Malcolm, what is your mother's maiden name? I just have a few more questions. Before we were at I.

00:38:59
Speaker 2: Know it's like a ludicrous and so it's fine for those guys to scour, you know, the Internet and put together massive dossiers of everything, every fact about me. But somehow, if I want to allow someone to peek into my is it physiological, you know, for the benefit of mankind? That's a problem. Just drives me crazy.

00:39:21
Speaker 1: It is a problem, And I didn't know that I hit a nerve with that one word privacy. But here we are, so that I think is a nice place to wrap up our starvation study, except for one final question. One listener was really fascinated by the cinnamon role of recipe from the episode of the Starvation Study Tara A. She said, thank you for these episodes, Malcolm. So, Malcolm, thank you for these episodes. Any chance you know how we could track down that cinnamon roll recipe. I was thinking would be nice to make some and share in my community and for a refresher for listeners who don't love cinnamon roles as much as I do. So did it immediately light up at this detail. So there was a character in the episode, Lester Glick, who was part of this study and one of the things that mentally fortified him. Although I think for me it would have probably had the opposite effect. As he carried around a picture of a cinnamon roll and he had it with him always, and it was something that kept him going.

00:40:22
Speaker 2: And then later he would for the rest of his life he would make them obsessively for family and friends, by the dozens. It was the defining one of the defining acts of the rest of his life.

00:40:34
Speaker 1: Now, I love cinnamon rolls, so I also wanted to track down that recipe.

00:40:39
Speaker 2: We will post it online in all those brave souls who want to recreate the famous cinnamon rolls can do that. That was fun. Thank you, Maria. That's really fun, of course. Thank you, Bye bye, Maria, Maria, Maria, thank you so much for agreeing to take on the role of revisionist histories inaugural homless person. Just so all of you know, we hope to make Maria a regular on the show in the future. You may have thought she went easy on me this time. Let me just say I have no expectation that will ever happen again. Oh, if you're wondering why I said it takes bravery to make the cinnamon rolls, let's just say the recipe involves among other things mash potatoes. Go to our website and see for yourself, and thank you to the Glick family for sharing that with us. Maria will be back soon, So send your questions, your challenges, your gripes, and your stories to all of us at revisionististory dot com. Revision's History is produced by Leaming Gestou, Amy gains Kiara Powell, and Jacob Smith. Our showrunner is Peter Clowney. Original scoring by Luis Gara, mastering by Sarah Braguaire and engineering by Nina Lawrence. Fact checking by Mishelle Williams. Special thanks to Julia Barton. Subscribe to pushkin plus to hear all our episodes of Revisionist History add free, and as of this year, get our shows two weeks earlier than the rest of the world. I'm Malcolm Pampa.