Train Your Brain To Thrive Through Menopause

The 'Pause Life by Dr. Mary Claire Haver - The unPaused Podcast

In this episode of unPAUSED, Dr. Mary Claire Haver sits down with Dr. Sue Varma, a board certified psychiatrist, distinguished fellow of the American Psychiatric Association, and author of Practical Optimism. They open by taking on a question that sits at the intersection of psychiatry and menopause medicine: why do some women thrive through the most difficult biological transition of their lives, and what can the rest of us learn from them?

Early in the conversation, Dr. Varma shares a finding that reframes everything: only 25% of people are born optimistic, and there is actually a gene for it. The other 75% have to learn it. Dr. Varma explains why optimism is not toxic positivity, what practical optimism actually means, and why both extreme optimists and extreme pessimists end up paralyzed into inaction in different ways. She also addresses what happens when depression, anxiety, and brain fog layer on top of the hormonal changes of menopause and perimenopause, and why so many women are being undertreated as a result.

Dr. Varma walks through the practical applications of her framework, explaining why waiting for motivation to strike is a losing strategy, how chronic stress and cortisol keep women stuck in survival mode, how to move healthy behaviors out of the prefrontal cortex and into the basal ganglia where they become automatic, and why lowering the entry barrier rather than overcommitting is the key to building habits that stick. She also covers the U-shaped happiness curve, why 47 to 48 is statistically the lowest point of midlife happiness and coincides with peak perimenopause, and why that nadir is actually an opportunity for rebuilding.

Dr. Varma and Dr. Haver also dig into shame and the failure cycle many women experience in midlife, the default mode network and how rumination takes hold, the four steps of emotional processing, and what the four Ms of mental health, movement, mastery, meaningful engagement, and mindfulness, look like in daily practice. They also cover loneliness in midlife, the sandwich generation, sleep disruption and the 3:00 AM wake-up cycle, and why a worry journal works better than most people expect.

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2026-06-23

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