S1.E2: Phenols and Sulfonamides Are Cool!

Pharm to Table

For our 2nd course, a #winning #MerckChemistry duo, Patrick Fier and Kevin Maloney, join us to discuss their discovery of the Maloney-Fier reaction (campaigning to be in the 2nd edition of the indispensable Strategic Applications of Named Reaction in Organic Synthesis by Kurti/Czako) as well as other projects they've collaborated on in the last few years. We'll uncover why these two work so well together and how they balance exploring scientific curiosities while having day jobs as successful process chemists. Dani and LC also try to find out which famous duo they are most like: Batman and Robin? Han Solo and Chewy? Listen to find out!

Read their papers we discussed today here:

Direct Conversion of Haloarenes to Phenols under Mild, Transition-Metal-Free Conditions

Synthesis of Complex Phenols Enabled by a Rationally Designed Hydroxide Surrogate

Reagent Design and Ligand Evolution for the Development of a Mild Copper-Catalyzed Hydroxylation Reaction

NHC-Catalyzed Deamination of Primary Sulfonamides: A Platform for Late-Stage Functionalization

Reductive Cleavage of Secondary Sulfonamides: Converting Terminal Functional Groups into Versatile Synthetic Handles

Follow the Pharm to Table podcast on Twitter - @PharmToTablePod

2021-08-02 31 min

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