#040 Dr. Eric Verdin on Ketogenic Diet Longevity, Beta-Hydroxybutyrate & HDAC Inhibitors

Eric M. Verdin

Eric M. Verdin, M.D. is the fifth president and chief executive officer of the Buck Institute for Research on Aging and is a professor of Medicine at UCSF.

Dr. Verdin's laboratory focuses on the role of epigenetic regulators in the aging process, the role of metabolism and diet in aging and on the chronic diseases of aging, including Alzheimer's, proteins that play a central role in linking caloric restriction to increased healthspan, and more recently a topic near and dear to many of you, ketogenesis. He's held faculty positions at the University of Brussels, the NIH and the Picower Institute for Medical Research.

In this episode, you'll discover:

• (00:00) Introduction
• (07:32) Interventions to prolong lifespan
• (10:42) The role of insulin pathways in aging
• (16:25) HDAC inhibition by ketones
• (27:52) Protein activates mTOR & IGF-1
• (30:28) PPAR-alpha activation facilitates benefits of a ketogenic diet
• (35:28) What biomarkers can predict aging?
• (39:38) Cellular NAD+ levels decrease with age
• (52:47) Ketogenic diet safety
• (56:07) Intermittent fasting as an alternative to a keto diet

If you're interested in learning more, you can read the full show notes here.

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