Chris Mirabile: Why One Ingredient Will Never Stop You From Aging (And What Actually Does)

Most of what the supplement and skincare industry sells for aging targets one pathway at a time. But your biology does not age that way. It declines across 12 interconnected processes simultaneously, and by the time one of them shows up on your skin, the others have already been running for years.

We at Young Goose believe that skin longevity is not a topical problem. It is a whole biology problem, and the ingredients you choose, how they interact, and whether anyone has actually tested them together matters more than any single molecule ever could.

In this episode, we are joined for the second time around by Chris Mirabile, founder of NOVOS which is the first biotech company to target all 12 biological causes of aging. Chris collaborates with leading researchers at Harvard and MIT and has built his work around one premise: that real interventions require real testing on real humans, not just promising ingredients.

Let's dive in.

What's Discussed:

• (2:14) Why single ingredient marketing is a commercial story, not a scientific one.
• (9:56) The three hallmarks hitting skin hardest and how they feed each other.
• (12:02) How UV damage depletes 90% of NAD in the skin from a single exposure event.
• (22:14) Why stacking molecules requires human testing, not just ingredient research.
• (33:48) The NOVOS cardiovascular study and results that surprised the researchers.
• (48:12) Why spending more on your biology does not make your protocol safe.
• (1:02:18) What omics testing reveals that epigenetics alone cannot tell you.
• (1:09:45) Where skin longevity is heading in the next five years.

Find more from Young Goose:

• Use code PODCAST10 to get 10% OFF your first purchase, and if you’re a returning customer use the code PODCAST5 to get 5% OFF at younggoose.com
• Instagram: @young_goose_skincare

Find more from Chris Mirabile & Slow My Age:

Instagram: @slowmyage

YouTube: @slowmyage

TikTok:@slowmyage

X: @slowmyage

Personal Blog: slowmyage.com

Find more from NOVOS:

Website: NOVOSlabs.com

Instagram: @NOVOSlabs

Facebook: NOVOS

Youtube: @NOVOSlabs

TikTok: @NOVOSlabs_

X: @NOVOSLabs