273. The New Wave of Peptides That Could Change How We Age and Perform

The Kris Gethin Podcast

The peptide space is moving so fast that by the time a compound starts blowing up online, there is already something newer coming behind it. If you care about performance, recovery, body composition, hormones, or longevity, you need to know where this field is heading before the next wave of protocols and opinions hits your feed. Knowing what people are experimenting with now gives you a much better chance of separating something worth watching from another compound getting hyped to hell.

In this episode, Alex Kikel and I get into the new peptides, small molecules, and therapies starting to push this space forward. We talk about what is developing around mitochondria and endogenous hormone production, why Klotho is getting more attention, how far this conversation is moving beyond traditional peptides, and several compounds that could be names you hear a hell of a lot more about over the next few years.

Alex has spent roughly a decade studying and applying peptides, small molecules, bioregulators, and emerging compounds through his own experimentation and work with clients. His background also includes relationships with professionals connected to Eli Lilly and Pfizer, independent chemical synthesizers, consulting work on experimental compounds, and years of hands-on protocol development.

What's Discussed:

(00:00) Where the peptide industry is heading and the compounds starting to come down the pipeline.

(00:57) S-Mitochonic Acid 5-Ethyl Ester and why mitochondrial function is becoming such a major target.

(07:36) Phoenixin-20, neurological signaling, and endogenous hormone production.

(10:19) How Phoenixin-20 compares with enclomiphene, HCG, HMG, and kisspeptin.

(13:03) Klotho, recombinant Klotho, peptide forms, gene therapy, and why it is getting so much attention in longevity.

(21:46) Plasma exchange, EBOO, ozone, and young plasma.

(28:27) HDAP2, why Alex believes it could move beyond SS-31, and what happens when the dose is too much for the individual.

As usual, this episode is for education only. Some of what we discuss is still experimental, investigational, or needs proper medical supervision, so do your homework before you start playing with any of it.

To receive my free book, A Guide to Biohacking, leave an honest review on the platform where you listen to the podcast, then email a screenshot to info@krisgethin.com.

Find More From Kris Gethin

Website: krisgethin.com/

Instagram: @krisgethin/

YouTube: youtube.com/krisgethin

2 Shred: unmatchedsupps.com/products/2shred

Find Out More About Alex Kikel

Website: theprepcoach.com/

Instagram:@alex_kikel

YouTube: @alexkikelTPC

TPC Army: skool.com/tpcarmy/about

More description

The peptide space is moving so fast that by the time a compound starts blowing up online, there is already something newer coming behind it. If you care about performance, recovery, body composition, hormones, or longevity, you need to know where this field is heading before the next wave of protocols and opinions hits your feed. Knowing what people are experimenting with now gives you a much better chance of separating something worth watching from another compound getting hyped to hell.

In this episode, Alex Kikel and I get into the new peptides, small molecules, and therapies starting to push this space forward. We talk about what is developing around mitochondria and endogenous hormone production, why Klotho is getting more attention, how far this conversation is moving beyond traditional peptides, and several compounds that could be names you hear a hell of a lot more about over the next few years.

Alex has spent roughly a decade studying and applying peptides, small molecules, bioregulators, and emerging compounds through his own experimentation and work with clients. His background also includes relationships with professionals connected to Eli Lilly and Pfizer, independent chemical synthesizers, consulting work on experimental compounds, and years of hands-on protocol development.

What's Discussed:

(00:00) Where the peptide industry is heading and the compounds starting to come down the pipeline.

(00:57) S-Mitochonic Acid 5-Ethyl Ester and why mitochondrial function is becoming such a major target.

(07:36) Phoenixin-20, neurological signaling, and endogenous hormone production.

(10:19) How Phoenixin-20 compares with enclomiphene, HCG, HMG, and kisspeptin.

(13:03) Klotho, recombinant Klotho, peptide forms, gene therapy, and why it is getting so much attention in longevity.

(21:46) Plasma exchange, EBOO, ozone, and young plasma.

(28:27) HDAP2, why Alex believes it could move beyond SS-31, and what happens when the dose is too much for the individual.

As usual, this episode is for education only. Some of what we discuss is still experimental, investigational, or needs proper medical supervision, so do your homework before you start playing with any of it.

To receive my free book, A Guide to Biohacking, leave an honest review on the platform where you listen to the podcast, then email a screenshot to info@krisgethin.com.

Find More From Kris Gethin

Website: krisgethin.com/

Instagram: @krisgethin/

YouTube: youtube.com/krisgethin

2 Shred: unmatchedsupps.com/products/2shred

Find Out More About Alex Kikel

Website: theprepcoach.com/

Instagram:@alex_kikel

YouTube: @alexkikelTPC

TPC Army: skool.com/tpcarmy/about

2026-08-27 51 min
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