Quantum sensors monitor brain development in children
Margot Taylor – director of functional neuroimaging at Toronto’s Hospital for Sick Children – is our first guest in this podcast. She explains how she uses optically-pumped magnetometers (OPMs) to do magnetoencephalography (MEG) studies of brain development in children.
An OPM uses quantum spins within an atomic gas to detect the tiny magnetic fields produced by the brain. Unlike other sensors used for MEG, which must be kept at cryogenic temperatures, OPMs can be deployed at room temperature in a simple helmet that puts the sensors very close to the scalp.
The OPM-MEG helmets are made by Cerca Magnetics and the UK-based company’s managing director joins the conversation to explain how the technology works. David Woolger also talks about the success the company has enjoyed since its inception in 2020.
Our final guest in this podcast is Stuart Nicol, who is chief investment officer at Quantum Exponential – a UK-based company that invests in quantum start-ups. He gives his perspective on the medical sector, talks about a company called Siloton that is making a crucial eye-imaging technology more accessible.
- This podcast was recorded at the Commercialising Quantum 2024 conference.
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1 00:00:07,200 --> 00:00:10,240 Hello, and welcome to the Physics World weekly 2 00:00:10,240 --> 00:00:12,259 podcast. I'm Hamish Johnston. 3 00:00:12,755 --> 00:00:15,575 This episode explores how quantum technologies 4 00:00:16,114 --> 00:00:17,015 have the potential 5 00:00:17,315 --> 00:00:18,295 to revolutionize 6 00:00:18,755 --> 00:00:19,255 medicine. 7 00:00:20,114 --> 00:00:22,675 First up, we hear from a professor of 8 00:00:22,675 --> 00:00:24,935 medical imaging and psychology 9 00:00:25,554 --> 00:00:27,494 who uses quantum sensors 10 00:00:27,850 --> 00:00:30,510 to study brain development in children. 11 00:00:31,289 --> 00:00:34,109 And we also hear from the managing director 12 00:00:34,329 --> 00:00:38,010 of the company that's created the technology she 13 00:00:38,010 --> 00:00:38,510 uses. 14 00:00:39,450 --> 00:00:41,690 A bit later on, I chat with a 15 00:00:41,690 --> 00:00:42,670 venture capitalist 16 00:00:43,005 --> 00:00:45,185 who funds companies that develop 17 00:00:45,565 --> 00:00:47,664 quantum technologies for Madison. 18 00:00:48,765 --> 00:00:51,565 But first, Physics World is brought to you 19 00:00:51,565 --> 00:00:53,185 by IOP Publishing, 20 00:00:53,804 --> 00:00:56,065 which is pleased to announce that the journal 21 00:00:56,479 --> 00:00:57,700 Progress in Energy 22 00:00:58,079 --> 00:01:00,340 is extending its article remit 23 00:01:00,719 --> 00:01:03,219 and now accepts original research. 24 00:01:04,000 --> 00:01:06,420 This means that you can publish your groundbreaking 25 00:01:06,879 --> 00:01:07,379 research 26 00:01:07,760 --> 00:01:08,260 alongside 27 00:01:08,719 --> 00:01:10,260 some of our most impactful 28 00:01:11,125 --> 00:01:13,064 and cited reviews on energy. 29 00:01:14,165 --> 00:01:14,665 PRGE 30 00:01:15,204 --> 00:01:16,504 is a high impact, 31 00:01:17,125 --> 00:01:17,625 multidisciplinary 32 00:01:18,484 --> 00:01:21,384 journal focusing on a wide range of issues 33 00:01:21,844 --> 00:01:24,424 related to the global energy transition. 34 00:01:25,590 --> 00:01:28,150 We invite you to publish with us and 35 00:01:28,150 --> 00:01:30,729 share your work with a global audience. 36 00:01:31,430 --> 00:01:34,729 You can find the journal at IOP Science. 37 00:01:35,430 --> 00:01:37,909 Earlier this year, I found myself in the 38 00:01:37,909 --> 00:01:39,769 heart of the city of London 39 00:01:40,084 --> 00:01:41,784 in a gleaming skyscraper 40 00:01:42,164 --> 00:01:43,625 hosting the commercializing 41 00:01:44,244 --> 00:01:45,305 quantum conference. 42 00:01:46,325 --> 00:01:47,784 Organized by economist 43 00:01:48,164 --> 00:01:48,664 impact 44 00:01:49,045 --> 00:01:52,344 the event brought together people from quantum technology 45 00:01:52,564 --> 00:01:54,680 companies and their customers 46 00:01:55,299 --> 00:01:56,520 real and imagined. 47 00:01:57,299 --> 00:01:59,480 While much of the focus was on quantum 48 00:01:59,540 --> 00:02:00,040 computing 49 00:02:00,340 --> 00:02:03,719 there was also lots of talk about quantum 50 00:02:03,780 --> 00:02:04,280 sensors. 51 00:02:05,635 --> 00:02:07,415 Medicine is an important 52 00:02:07,715 --> 00:02:09,974 early application of quantum sensors, 53 00:02:10,514 --> 00:02:13,094 and delegates were treated to a fascinating 54 00:02:13,474 --> 00:02:13,974 presentation 55 00:02:14,514 --> 00:02:15,895 by Margo Taylor, 56 00:02:16,194 --> 00:02:17,175 who is director 57 00:02:17,474 --> 00:02:18,215 of functional 58 00:02:18,675 --> 00:02:19,175 neuroimaging 59 00:02:20,189 --> 00:02:22,289 at the Hospital For Sick Children 60 00:02:22,590 --> 00:02:23,409 in Toronto. 61 00:02:24,430 --> 00:02:26,289 She uses special helmets 62 00:02:26,590 --> 00:02:28,530 adorned with quantum sensors 63 00:02:28,989 --> 00:02:29,650 to do 64 00:02:30,030 --> 00:02:30,530 magnetoencephalography 65 00:02:32,189 --> 00:02:34,289 studies of the brain development 66 00:02:34,669 --> 00:02:35,409 of children. 67 00:02:36,504 --> 00:02:39,085 I caught up with Margo after her presentation 68 00:02:39,944 --> 00:02:42,044 along with co speaker David 69 00:02:42,344 --> 00:02:42,844 Wolger, 70 00:02:43,224 --> 00:02:46,444 who is managing director of UK based 71 00:02:46,905 --> 00:02:47,884 Circa Magnetics, 72 00:02:48,620 --> 00:02:50,879 the company that makes the helmets. 73 00:02:51,500 --> 00:02:54,060 We spoke in a quiet corner of the 74 00:02:54,060 --> 00:02:57,520 conference center, but you will hear some enthusiastic 75 00:02:57,979 --> 00:02:59,439 delegates in the background. 76 00:03:00,300 --> 00:03:01,919 Here is that conversation. 77 00:03:08,465 --> 00:03:10,324 So, Morgo, what is magnetoencephalography, 78 00:03:11,504 --> 00:03:13,284 and how is it used in medicine? 79 00:03:13,905 --> 00:03:14,405 So 80 00:03:14,784 --> 00:03:15,284 magnetoencephalography 81 00:03:16,145 --> 00:03:16,965 or MEG 82 00:03:17,530 --> 00:03:19,789 is used to look at brain function, 83 00:03:20,250 --> 00:03:22,430 and it is the probably the most sensitive 84 00:03:22,729 --> 00:03:25,849 measure, the most sensitive means we have of 85 00:03:25,849 --> 00:03:28,650 assessing brain function. There are other techniques for 86 00:03:28,650 --> 00:03:31,125 looking at brain function, but MEG gives us 87 00:03:31,125 --> 00:03:32,905 amazing temporal resolution 88 00:03:33,284 --> 00:03:35,284 as well as well as very good spatial 89 00:03:35,284 --> 00:03:35,784 resolution. 90 00:03:36,485 --> 00:03:38,025 And it it's very valuable. 91 00:03:38,485 --> 00:03:40,965 And and when you say brain function, it's 92 00:03:40,965 --> 00:03:43,385 specifically looking at electrical activity? 93 00:03:43,844 --> 00:03:45,685 Yes. Yes. So it doesn't give us any 94 00:03:45,685 --> 00:03:48,219 information about the structure of the brain, but 95 00:03:48,219 --> 00:03:49,759 about the function of the brain. 96 00:03:50,060 --> 00:03:51,199 And the disorders 97 00:03:51,659 --> 00:03:53,979 that I'm interested in are disorders of brain 98 00:03:53,979 --> 00:03:54,479 function, 99 00:03:54,780 --> 00:03:56,479 and they rarely are 100 00:03:57,019 --> 00:03:58,113 disorders of brain structure. So you're measuring electrical 101 00:03:58,113 --> 00:03:58,799 signals. Does that mean that the brain is, 102 00:03:59,585 --> 00:04:00,085 electrical 103 00:04:01,105 --> 00:04:01,605 signals. 104 00:04:02,385 --> 00:04:02,790 Does that mean that the brain is, essentially 105 00:04:02,790 --> 00:04:03,605 an electrical device? Yeah. They are hugely complex, 106 00:04:04,865 --> 00:04:05,925 electrical device. Well, it's 107 00:04:06,625 --> 00:04:07,125 electrochemical, 108 00:04:08,224 --> 00:04:09,665 but we are measuring the electrical signals that 109 00:04:09,665 --> 00:04:11,284 are the product 110 00:04:14,090 --> 00:04:14,909 of the electrochemical 111 00:04:15,209 --> 00:04:17,129 reactions in the brain. When you say that 112 00:04:17,129 --> 00:04:19,529 you're not looking at structure, does that mean 113 00:04:19,529 --> 00:04:21,629 that you get, just an overall 114 00:04:22,329 --> 00:04:24,649 signal from the brain, or can you actually 115 00:04:24,649 --> 00:04:27,370 get some structural information? Do you know where 116 00:04:27,370 --> 00:04:29,954 that signal's coming from? We usually get a 117 00:04:30,115 --> 00:04:32,595 structural MRI as well, and then we have 118 00:04:32,595 --> 00:04:34,214 very good source localization 119 00:04:34,675 --> 00:04:35,175 approaches 120 00:04:35,714 --> 00:04:38,194 so that we can tell where exactly where 121 00:04:38,194 --> 00:04:41,175 in the brain those different signals are arising 122 00:04:41,634 --> 00:04:43,634 and how they are connecting with each other 123 00:04:43,634 --> 00:04:44,534 and the interactions 124 00:04:44,834 --> 00:04:47,689 amongst different brain regions and the timing of 125 00:04:47,689 --> 00:04:48,430 that interaction. 126 00:04:48,889 --> 00:04:51,370 So, Margo, why does Quantum MEG make it 127 00:04:51,370 --> 00:04:53,790 easier to do brain scans on children? 128 00:04:54,970 --> 00:04:56,990 Because the the quantum technology 129 00:04:57,704 --> 00:05:00,664 is now wearable because of the OPM systems, 130 00:05:00,664 --> 00:05:02,365 the optically pumped magnetometers, 131 00:05:03,064 --> 00:05:04,745 and therefore, they can be put into a 132 00:05:04,745 --> 00:05:07,384 helmet that the child can wear. And so 133 00:05:07,384 --> 00:05:09,930 if the child is wearing a helmet, there 134 00:05:10,089 --> 00:05:12,889 is allowed movement because the helmet moves with 135 00:05:12,889 --> 00:05:15,229 the child, and so we're able to actually 136 00:05:15,289 --> 00:05:17,789 record brain signals in the very young children 137 00:05:17,850 --> 00:05:19,289 because they can move. They can sit on 138 00:05:19,289 --> 00:05:21,289 their parents' lap. They don't have to be 139 00:05:21,289 --> 00:05:24,509 lying perfectly still. And, also, the other thing, 140 00:05:24,649 --> 00:05:27,664 you said that cryogenic, the classic MEG, 141 00:05:28,204 --> 00:05:31,485 is, a one size fits all, typically. So 142 00:05:31,485 --> 00:05:34,204 it's designed for an adult male head. And 143 00:05:34,204 --> 00:05:36,444 if you put in a small child, they're 144 00:05:36,444 --> 00:05:38,604 a long ways away from the sensors. And 145 00:05:38,604 --> 00:05:40,224 so with the OPMs, 146 00:05:40,620 --> 00:05:42,139 they're in a helmet that can be a 147 00:05:42,139 --> 00:05:44,800 different sized helmet for different sized head. 148 00:05:45,180 --> 00:05:47,180 And so we have little tiny helmets up 149 00:05:47,180 --> 00:05:49,339 to bigger helmets. And so the sensors are 150 00:05:49,339 --> 00:05:51,500 much closer to the child's head. The child 151 00:05:51,500 --> 00:05:54,220 can be sitting on the parent's lap. Child 152 00:05:54,220 --> 00:05:55,995 can move. And it's just 153 00:05:56,794 --> 00:05:58,735 a game changer in terms of recording 154 00:05:59,035 --> 00:06:02,074 signals in little children. I see. And and 155 00:06:02,074 --> 00:06:03,915 one thing that I wanted to ask you 156 00:06:03,915 --> 00:06:05,834 is when when I was watching your talk, 157 00:06:05,834 --> 00:06:07,134 I I saw the helmet, 158 00:06:07,834 --> 00:06:09,569 you know, on various children's heads. And I 159 00:06:09,569 --> 00:06:11,969 thought of when I wear my bicycle helmet, 160 00:06:11,969 --> 00:06:14,129 it's, you know, it sort of wobbles around 161 00:06:14,129 --> 00:06:15,969 a bit. Does does the helmet have to 162 00:06:15,969 --> 00:06:18,209 be very tight on their head so it 163 00:06:18,209 --> 00:06:19,110 doesn't wobble? 164 00:06:19,810 --> 00:06:21,750 Yes. It needs to be reasonably well, 165 00:06:22,209 --> 00:06:22,709 positioned. 166 00:06:23,089 --> 00:06:26,035 And so we have, nice soft linings inside. 167 00:06:26,035 --> 00:06:28,355 We have several layers of lining depending on 168 00:06:28,355 --> 00:06:29,095 the child's 169 00:06:29,475 --> 00:06:31,475 head so that even though we have the 170 00:06:31,475 --> 00:06:33,714 right helmet size for the child's head, we 171 00:06:33,714 --> 00:06:35,714 can also put in, like, an an extra 172 00:06:35,714 --> 00:06:38,160 thin layer just to make sure it fits 173 00:06:38,399 --> 00:06:40,480 nicely, and we have a little chinstrap, a 174 00:06:40,480 --> 00:06:43,680 little cloth chinstrap just to keep it from 175 00:06:43,680 --> 00:06:46,560 falling off. I see. And and do do 176 00:06:46,560 --> 00:06:48,399 do you ask the children to to stay 177 00:06:48,399 --> 00:06:51,199 still or are they free to to move 178 00:06:51,199 --> 00:06:53,235 around, or, or, you know, would you like 179 00:06:53,235 --> 00:06:54,834 would you like them to stay as still 180 00:06:54,834 --> 00:06:56,595 as possible? We we like them to stay 181 00:06:56,595 --> 00:06:59,014 reasonably still. And in some, 182 00:06:59,475 --> 00:07:00,375 of the newer, 183 00:07:01,555 --> 00:07:03,415 rooms that are used for OPMs, 184 00:07:03,795 --> 00:07:05,394 they don't need to stay as still, but 185 00:07:05,394 --> 00:07:07,394 the room that we have, they need to 186 00:07:07,394 --> 00:07:10,819 stay reasonably still. So, Margo, you're you're currently 187 00:07:10,819 --> 00:07:12,599 leading a study at SickKids 188 00:07:13,060 --> 00:07:15,079 that's using Quantum MEG, 189 00:07:15,620 --> 00:07:18,019 that's using a Quantum MEG system from the 190 00:07:18,019 --> 00:07:19,719 UK's Circa Magnetics. 191 00:07:20,180 --> 00:07:22,225 Can you describe the study that you're 192 00:07:22,605 --> 00:07:24,545 doing? Sure. We are looking at 193 00:07:25,004 --> 00:07:28,285 early brain function in children with and without 194 00:07:28,285 --> 00:07:28,785 autism. 195 00:07:29,404 --> 00:07:32,444 And so autism is usually diagnosed by about 196 00:07:32,444 --> 00:07:34,605 3 years of age, and the youngest is 197 00:07:34,605 --> 00:07:36,550 usually three years of age, although sometimes it's 198 00:07:36,550 --> 00:07:38,009 not diagnosed till later. 199 00:07:38,550 --> 00:07:42,170 But if a child could be diagnosed or 200 00:07:42,230 --> 00:07:46,149 detected to have autism earlier, then interventions could 201 00:07:46,149 --> 00:07:47,050 start earlier. 202 00:07:47,430 --> 00:07:49,529 And interventions are very effective, 203 00:07:50,550 --> 00:07:51,694 at ameliorating, 204 00:07:52,474 --> 00:07:53,534 some of the symptoms. 205 00:07:53,995 --> 00:07:56,474 And so we're looking at children with and 206 00:07:56,474 --> 00:07:59,274 without autism, but including children that have a 207 00:07:59,274 --> 00:08:00,094 high likelihood 208 00:08:00,394 --> 00:08:02,875 of developing autism to see if we can 209 00:08:02,875 --> 00:08:05,939 get brain signals that will predict that whether 210 00:08:05,939 --> 00:08:08,279 they will go on to get a diagnosis 211 00:08:08,419 --> 00:08:09,079 or not. 212 00:08:09,620 --> 00:08:11,620 I see. And and in your talk today, 213 00:08:11,939 --> 00:08:13,459 you showed some slides with, 214 00:08:14,419 --> 00:08:17,985 data showing signals from children's brains and how 215 00:08:18,144 --> 00:08:19,204 respond to, 216 00:08:20,064 --> 00:08:20,564 faces. 217 00:08:21,425 --> 00:08:23,024 Can you talk a bit about that? How 218 00:08:23,024 --> 00:08:25,264 how how do those responses how do they 219 00:08:25,264 --> 00:08:26,004 look different, 220 00:08:27,264 --> 00:08:29,584 using MEG from, you know, maybe somebody who 221 00:08:29,584 --> 00:08:32,789 might be developing autism to somebody who doesn't 222 00:08:32,789 --> 00:08:33,370 have it? 223 00:08:33,830 --> 00:08:36,710 We don't have those data yet because we're 224 00:08:36,710 --> 00:08:38,870 looking at the children who have a high 225 00:08:38,870 --> 00:08:41,450 likelihood of autism, but we don't know yet. 226 00:08:41,910 --> 00:08:43,350 So we're we have to wait till they 227 00:08:43,350 --> 00:08:45,404 grow up and for another year or so 228 00:08:45,404 --> 00:08:46,865 to see if they get a diagnosis. 229 00:08:47,325 --> 00:08:49,664 For the children who do have a diagnosis 230 00:08:49,884 --> 00:08:52,544 already of autism, it seems like the responses 231 00:08:52,605 --> 00:08:55,325 are not quite typical, but we haven't fully 232 00:08:55,325 --> 00:08:57,964 analyzed those data. And so we think that 233 00:08:57,964 --> 00:08:59,565 there is a signal there that we'll be 234 00:08:59,565 --> 00:09:01,879 able to report in the foreseeable future. 235 00:09:02,180 --> 00:09:04,660 But we're we only have tested 32 children 236 00:09:04,660 --> 00:09:06,420 with autism so far, and we'd like to 237 00:09:06,420 --> 00:09:08,360 get a a bit more, 238 00:09:08,820 --> 00:09:11,700 data before we publish it. I see. So, 239 00:09:11,700 --> 00:09:13,960 Margo, are you able to share any preliminary 240 00:09:14,100 --> 00:09:16,615 results with us at the moment? Or have 241 00:09:16,615 --> 00:09:17,274 you published, 242 00:09:17,975 --> 00:09:19,914 papers based on this data yet? 243 00:09:20,534 --> 00:09:23,654 Not yet. No. Sorry. We're still analyzing data. 244 00:09:23,654 --> 00:09:24,714 We're seeing beautiful, 245 00:09:25,654 --> 00:09:27,654 age related changes in our young in our 246 00:09:27,654 --> 00:09:29,975 young typically developing children, because we had to, 247 00:09:29,975 --> 00:09:30,554 of course, 248 00:09:30,970 --> 00:09:31,789 establish what 249 00:09:32,330 --> 00:09:34,889 happens in typical children before we could compare 250 00:09:34,889 --> 00:09:37,210 it to children with autism or high likelihood 251 00:09:37,210 --> 00:09:39,210 of autism. Because nobody has been able to 252 00:09:39,210 --> 00:09:41,870 do these studies before because of this technology. 253 00:09:41,929 --> 00:09:43,705 We're the sort of the first to have 254 00:09:43,705 --> 00:09:45,404 these studies, so we have to establish 255 00:09:46,105 --> 00:09:49,004 the fundamental, the foundational datasets. 256 00:09:49,384 --> 00:09:51,304 And those will be able to publish very 257 00:09:51,304 --> 00:09:51,804 shortly. 258 00:09:52,105 --> 00:09:54,184 I see. Okay. Well, looking forward to seeing 259 00:09:54,184 --> 00:09:57,179 those. Beyond this study that you're doing on 260 00:09:57,179 --> 00:09:59,740 autism, are are you using the MEG system 261 00:09:59,740 --> 00:10:01,660 for for anything else at the moment at 262 00:10:01,660 --> 00:10:02,320 Sick Kids? 263 00:10:03,340 --> 00:10:05,440 So the OPM system, we're also, 264 00:10:05,980 --> 00:10:08,835 setting up studies, to look at children with 265 00:10:08,995 --> 00:10:11,715 epilepsy to compare with the cryogenic and other 266 00:10:11,715 --> 00:10:13,735 imaging technologies with colleagues. 267 00:10:14,675 --> 00:10:17,795 We're also looking at, children who have a 268 00:10:17,795 --> 00:10:19,254 known genetic disorder 269 00:10:19,634 --> 00:10:22,514 to see if they also have brain signals 270 00:10:22,514 --> 00:10:24,535 that predict whether they go on to 271 00:10:24,970 --> 00:10:25,950 experience a neurodevelopmental 272 00:10:26,490 --> 00:10:29,470 disorder. And then we're also looking at children 273 00:10:29,690 --> 00:10:32,190 who are born to parents with HIV, 274 00:10:32,649 --> 00:10:34,029 mothers with HIV, 275 00:10:34,490 --> 00:10:36,970 and to see if we can get an 276 00:10:36,970 --> 00:10:40,924 indication of what is happening in their brains, 277 00:10:41,464 --> 00:10:44,044 that may affect their later development. 278 00:10:45,225 --> 00:10:45,725 Okay. 279 00:10:46,105 --> 00:10:48,824 Well, that's great. Thanks. We're also joined by 280 00:10:48,824 --> 00:10:50,444 David Wilger of Circumagnetics, 281 00:10:50,985 --> 00:10:53,404 which made the the the helmet system 282 00:10:53,784 --> 00:10:56,059 that Margo uses. David, can you can you 283 00:10:56,059 --> 00:10:58,699 just give us a brief description of the 284 00:10:58,699 --> 00:11:01,440 technology and how it works? So our technology 285 00:11:01,659 --> 00:11:03,519 uses optically pump magnetometers. 286 00:11:04,059 --> 00:11:07,839 They are very sensitive to magnetic fields. Effectively, 287 00:11:08,059 --> 00:11:09,995 we're sensing magnetic fields 288 00:11:10,455 --> 00:11:10,955 3,500 289 00:11:11,414 --> 00:11:11,914 times 290 00:11:12,294 --> 00:11:15,174 lower than the Earth's magnetic field. To enable 291 00:11:15,174 --> 00:11:17,514 us to do that, we actually need to 292 00:11:17,894 --> 00:11:20,774 shield against the Earth's magnetic field, so we 293 00:11:20,774 --> 00:11:23,379 do this in a shielded environment with both 294 00:11:23,379 --> 00:11:24,919 active and passive shielding, 295 00:11:25,379 --> 00:11:26,919 and we're then able to 296 00:11:27,459 --> 00:11:30,659 measure the magnetic fields from the brain. So 297 00:11:30,659 --> 00:11:31,959 when a neuron fires, 298 00:11:32,339 --> 00:11:34,659 you get an electrical field, and therefore you 299 00:11:34,659 --> 00:11:35,480 get a corresponding 300 00:11:36,019 --> 00:11:36,554 magnetic field. 301 00:11:51,620 --> 00:11:54,340 To understand functionally what's going on in that 302 00:11:54,340 --> 00:11:56,740 area. And and David, are there any other 303 00:11:56,740 --> 00:11:59,860 applications for this technology beyond, you know, the 304 00:11:59,860 --> 00:12:02,360 the helmets and and what Margo is doing? 305 00:12:02,580 --> 00:12:05,665 So, there's a vast number of applications within 306 00:12:05,884 --> 00:12:06,865 brain health. 307 00:12:07,325 --> 00:12:09,644 So, for example, we're working with a team 308 00:12:09,644 --> 00:12:11,565 in Oxford at the moment. We're looking at 309 00:12:11,565 --> 00:12:14,045 dementia studies. So, at the other end of 310 00:12:14,045 --> 00:12:14,785 the life, 311 00:12:15,325 --> 00:12:15,825 cycle, 312 00:12:16,340 --> 00:12:18,600 we're actually looking at how you can identify 313 00:12:18,740 --> 00:12:22,019 potentially dementia much earlier, and therefore, how you 314 00:12:22,019 --> 00:12:24,980 could potentially treat it with drugs or other 315 00:12:24,980 --> 00:12:25,480 interventions 316 00:12:25,860 --> 00:12:26,360 earlier. 317 00:12:27,139 --> 00:12:30,285 Outside brain health though, there's a number of 318 00:12:30,285 --> 00:12:33,085 groups who are using this quantum technology for 319 00:12:33,085 --> 00:12:36,205 other areas of medical science. So one group 320 00:12:36,205 --> 00:12:36,945 in Arkansas 321 00:12:37,565 --> 00:12:40,065 are actually looking at fetal imaging 322 00:12:40,684 --> 00:12:41,184 in, 323 00:12:41,929 --> 00:12:44,649 during pregnancy so that they can actually see 324 00:12:44,649 --> 00:12:47,950 much more clearly than has previously been possible. 325 00:12:48,250 --> 00:12:50,970 There's also another group in London that are 326 00:12:50,970 --> 00:12:54,649 looking at spinal imaging using the, optically pump 327 00:12:54,649 --> 00:12:55,149 magnetometers. 328 00:12:55,529 --> 00:12:58,165 So there's a vast range of 329 00:12:58,705 --> 00:13:01,105 medical imaging that can be done with these 330 00:13:01,105 --> 00:13:01,605 sensors. 331 00:13:02,785 --> 00:13:04,245 On a wider level, 332 00:13:05,665 --> 00:13:07,924 concussion is also something that 333 00:13:08,304 --> 00:13:11,125 potentially you can look at using these sensors. 334 00:13:11,184 --> 00:13:12,649 So for sports injury 335 00:13:13,110 --> 00:13:13,929 or potentially 336 00:13:14,549 --> 00:13:15,610 military injuries, 337 00:13:16,070 --> 00:13:19,110 there's a potential use again for the sensors 338 00:13:19,110 --> 00:13:20,250 in brain imaging. 339 00:13:20,709 --> 00:13:23,769 And and David, what about non medical applications? 340 00:13:23,829 --> 00:13:26,404 I mean, it sounds there's enough medical applications 341 00:13:26,465 --> 00:13:28,625 keep you busy for a very long time, 342 00:13:28,625 --> 00:13:31,285 but have you looked at non medical applications? 343 00:13:31,585 --> 00:13:33,684 So CIRCA haven't specifically. 344 00:13:33,985 --> 00:13:36,965 CIRCA are very much a medical imaging company, 345 00:13:37,345 --> 00:13:39,845 but I am very aware of other applications 346 00:13:41,230 --> 00:13:44,990 for imaging, for example, car batteries. So this 347 00:13:44,990 --> 00:13:47,549 has a real potential to be a big 348 00:13:47,549 --> 00:13:48,049 market. 349 00:13:48,669 --> 00:13:50,449 When they make car batteries, 350 00:13:50,750 --> 00:13:53,235 it's a chemistry that goes into the cells. 351 00:13:53,475 --> 00:13:55,794 If you can actually image those during the 352 00:13:55,794 --> 00:13:57,014 production process, 353 00:13:57,475 --> 00:14:00,534 you can effectively optimize that production process 354 00:14:01,075 --> 00:14:02,774 during the, production 355 00:14:03,235 --> 00:14:03,735 cycle, 356 00:14:04,195 --> 00:14:07,254 and therefore reduce your costs of battery production, 357 00:14:07,315 --> 00:14:08,454 which has a real 358 00:14:09,009 --> 00:14:11,809 potential benefit for use in electric cars and 359 00:14:11,809 --> 00:14:12,709 other applications. 360 00:14:13,490 --> 00:14:15,730 And and David, during your talk, you and 361 00:14:15,730 --> 00:14:18,149 Margo spoke together here at this Commercializing 362 00:14:18,450 --> 00:14:18,950 Quantum 363 00:14:19,490 --> 00:14:19,990 Conference. 364 00:14:20,529 --> 00:14:22,610 I mean, one thing about this this conference 365 00:14:22,610 --> 00:14:24,714 is that it looks towards the future, 366 00:14:25,414 --> 00:14:26,934 and there's a lot of, you know, sort 367 00:14:26,934 --> 00:14:27,914 of great plans 368 00:14:28,695 --> 00:14:30,934 being talked about. But one thing that really 369 00:14:30,934 --> 00:14:33,254 struck me when you spoke is that you 370 00:14:33,254 --> 00:14:35,674 said the the company was founded in 2020. 371 00:14:35,815 --> 00:14:38,110 Did I get that right? Yes. And that 372 00:14:38,110 --> 00:14:41,250 you've had, what, a positive cash flow ever 373 00:14:41,549 --> 00:14:43,470 every year since. Is that right? So you're 374 00:14:43,470 --> 00:14:43,970 actually 375 00:14:44,269 --> 00:14:46,589 you're doing things. You're making products. You're selling 376 00:14:46,589 --> 00:14:48,990 them, which, you know, is is that fairly 377 00:14:48,990 --> 00:14:50,690 unique for a quantum company? 378 00:14:51,389 --> 00:14:53,925 I believe it's unique for a quantum company. 379 00:14:53,925 --> 00:14:56,325 I'm obviously not aware of all the quantum 380 00:14:56,325 --> 00:14:56,825 companies, 381 00:14:57,365 --> 00:14:58,264 accounts, but 382 00:14:58,805 --> 00:15:01,285 we are in a good position in that 383 00:15:01,285 --> 00:15:04,425 we've been able to deliver our initial systems 384 00:15:04,485 --> 00:15:05,945 to the research Right. Market 385 00:15:06,404 --> 00:15:07,144 and actually 386 00:15:07,750 --> 00:15:10,870 deliver them for revenue, and we have made 387 00:15:10,870 --> 00:15:13,990 profit every year since we started trading. We 388 00:15:13,990 --> 00:15:15,850 have then reinvested that profit 389 00:15:16,389 --> 00:15:19,990 back into further development. So for example, looking 390 00:15:19,990 --> 00:15:21,914 at scanning 2 people at once, 391 00:15:22,235 --> 00:15:22,735 looking 392 00:15:23,195 --> 00:15:25,534 at other techniques so that we can continue 393 00:15:25,595 --> 00:15:28,174 to develop the product, and most importantly, 394 00:15:28,794 --> 00:15:31,695 for us, looking at the medical device approval. 395 00:15:32,074 --> 00:15:34,809 At the moment, our system is only sold 396 00:15:34,809 --> 00:15:36,190 to research institutes. 397 00:15:36,730 --> 00:15:39,309 We want to get, clinical approval 398 00:15:39,769 --> 00:15:41,610 in order to enable us to have the 399 00:15:41,610 --> 00:15:43,149 biggest societal impact 400 00:15:43,450 --> 00:15:46,250 for the product. We we believe if the 401 00:15:46,250 --> 00:15:49,514 product was available in every hospital, every doctor 402 00:15:49,754 --> 00:15:51,695 surgery, it could have some real 403 00:15:52,075 --> 00:15:56,154 big societal impact across the lifespan from scanning 404 00:15:56,154 --> 00:15:59,434 young children to scanning older people in the 405 00:15:59,434 --> 00:16:00,495 twilight years. 406 00:16:00,875 --> 00:16:02,950 Well, that's great. Thanks, David. Thanks for for 407 00:16:02,950 --> 00:16:05,590 filling us in on that. And, Margo, thanks 408 00:16:05,590 --> 00:16:07,670 for coming on the podcast as well. Oh, 409 00:16:07,670 --> 00:16:09,670 it was a pleasure talking with you. Thank 410 00:16:09,670 --> 00:16:10,170 you. 411 00:16:16,695 --> 00:16:19,834 CIRCA is a pioneer in the medical application 412 00:16:20,294 --> 00:16:21,674 of quantum technology. 413 00:16:22,534 --> 00:16:25,514 And no doubt, many companies around the world 414 00:16:25,654 --> 00:16:27,914 would want to emulate its success. 415 00:16:28,860 --> 00:16:31,419 While at the conference, I caught up with 416 00:16:31,419 --> 00:16:32,320 Stuart Nicholl, 417 00:16:32,700 --> 00:16:36,799 who is chief investment officer at Quantum Exponential, 418 00:16:37,740 --> 00:16:41,200 a UK based company that invests in quantum 419 00:16:41,259 --> 00:16:41,759 startups. 420 00:16:42,644 --> 00:16:44,745 We chatted about the medical sector, 421 00:16:45,125 --> 00:16:46,105 and in particular, 422 00:16:46,485 --> 00:16:49,144 about a company that is making a crucial 423 00:16:49,685 --> 00:16:51,384 eye imaging technology 424 00:16:52,165 --> 00:16:52,985 more accessible. 425 00:17:02,669 --> 00:17:03,409 So Stuart, 426 00:17:03,870 --> 00:17:07,490 Quantum Exponential is an investor in quantum technologies. 427 00:17:07,789 --> 00:17:08,929 Do you see medicine 428 00:17:09,309 --> 00:17:10,210 as an important 429 00:17:10,589 --> 00:17:11,089 application 430 00:17:11,549 --> 00:17:13,009 for quantum tech? 431 00:17:13,950 --> 00:17:16,164 Yeah. Absolutely. I guess it's the use case 432 00:17:16,164 --> 00:17:17,384 that we we hope 433 00:17:17,764 --> 00:17:20,585 most quantum will be, geared towards, albeit 434 00:17:21,044 --> 00:17:22,825 the current needs of defense, 435 00:17:24,005 --> 00:17:26,264 and environmental protection, you know, 436 00:17:26,579 --> 00:17:28,259 will mean it's used in those ways as 437 00:17:28,259 --> 00:17:29,960 well. I see. Okay. 438 00:17:30,579 --> 00:17:33,220 You've got a company called Cyloton. Have I 439 00:17:33,220 --> 00:17:36,659 said that right? Cyloton. Cyloton. I'm I'm My 440 00:17:36,659 --> 00:17:37,159 apologies. 441 00:17:39,220 --> 00:17:41,794 In your portfolio, and it's developing technology for 442 00:17:41,794 --> 00:17:42,755 medicine. Can you tell us about that company? 443 00:17:42,755 --> 00:17:43,255 Yeah. 444 00:17:43,634 --> 00:17:46,035 So they, they've developed based in Bristol, they've 445 00:17:46,035 --> 00:17:47,815 developed, photonic integrated chip, 446 00:17:53,539 --> 00:17:55,240 which they are using to 447 00:17:55,940 --> 00:17:56,440 shrink 448 00:17:56,740 --> 00:17:57,240 the 449 00:17:57,940 --> 00:17:58,440 eye 450 00:17:59,140 --> 00:18:00,119 measurement monitoring 451 00:18:00,980 --> 00:18:02,839 soft system that you would typically 452 00:18:03,140 --> 00:18:04,980 have in a hospital or an optician to 453 00:18:04,980 --> 00:18:05,720 look at 454 00:18:06,019 --> 00:18:08,359 in the initial use case of macular degeneration. 455 00:18:09,075 --> 00:18:10,595 So they've been able to basically, they can 456 00:18:10,595 --> 00:18:11,494 turn that into 457 00:18:11,954 --> 00:18:12,615 a rugged, 458 00:18:14,115 --> 00:18:14,615 portable 459 00:18:15,315 --> 00:18:17,174 unit, so people can hopefully 460 00:18:17,554 --> 00:18:20,115 monitor their eye health better, which is very 461 00:18:20,115 --> 00:18:22,534 important, in something like macular degeneration 462 00:18:22,859 --> 00:18:25,579 because as it begins to degrade or it 463 00:18:25,579 --> 00:18:26,079 changes, 464 00:18:26,539 --> 00:18:27,039 form, 465 00:18:27,579 --> 00:18:29,599 you're you're much more likely to save 466 00:18:29,900 --> 00:18:32,460 the eyesight or reduce its decline, and and 467 00:18:32,460 --> 00:18:35,579 that has, obviously, significant benefits to the patient, 468 00:18:35,579 --> 00:18:36,904 but also a lot 469 00:18:38,404 --> 00:18:41,605 cheaper, for the health service as well. And 470 00:18:41,605 --> 00:18:44,244 and we have covered that company, on Physics 471 00:18:44,244 --> 00:18:46,404 World. And so in the notes for this 472 00:18:46,404 --> 00:18:46,904 podcast, 473 00:18:47,365 --> 00:18:48,240 I'll, I'll mention 474 00:18:49,679 --> 00:18:51,679 Actually, I think it was a podcast interview 475 00:18:51,679 --> 00:18:53,839 as well. But I'll mention that in the 476 00:18:53,839 --> 00:18:54,339 notes. 477 00:18:54,640 --> 00:18:57,359 And and, Stuart, beyond medicine, what else is 478 00:18:57,359 --> 00:18:58,019 the company, 479 00:18:58,799 --> 00:18:59,779 interested in? 480 00:19:00,160 --> 00:19:01,759 Yeah. So we we we have a focus 481 00:19:01,759 --> 00:19:04,464 on investing in quantum technology, but we take 482 00:19:04,464 --> 00:19:06,464 that broad view of that, and that could 483 00:19:06,464 --> 00:19:07,284 even include, 484 00:19:09,024 --> 00:19:11,105 the supply chain for quantum, I think, is 485 00:19:11,105 --> 00:19:12,565 is pretty important as well. 486 00:19:12,865 --> 00:19:15,345 But currently, we have 7 investments. One's in 487 00:19:15,345 --> 00:19:16,724 quantum secure encryption, 488 00:19:18,750 --> 00:19:21,389 3, including a silicon, are in sensors, and 489 00:19:21,389 --> 00:19:22,609 the further 3 490 00:19:22,990 --> 00:19:25,470 are in quantum compute. I see. And you're 491 00:19:25,470 --> 00:19:26,609 here at the Commercializing 492 00:19:27,549 --> 00:19:29,085 Quantum Conference in 493 00:19:29,565 --> 00:19:30,065 London. 494 00:19:30,845 --> 00:19:33,565 Has anything new caught your eye? You you've 495 00:19:33,565 --> 00:19:35,484 been in the sessions. I've seen you there. 496 00:19:35,484 --> 00:19:38,044 Is there anything interesting that you've seen, so 497 00:19:38,044 --> 00:19:38,544 far? 498 00:19:38,924 --> 00:19:41,325 I think there's there's there's general optimism that 499 00:19:41,325 --> 00:19:42,625 we are actually getting 500 00:19:43,059 --> 00:19:43,880 closer to 501 00:19:44,339 --> 00:19:44,839 commercially 502 00:19:45,380 --> 00:19:45,880 sold, 503 00:19:46,420 --> 00:19:47,080 and useful, 504 00:19:47,940 --> 00:19:50,820 devices and equipments, and then my personal view 505 00:19:50,820 --> 00:19:52,580 is that then the software will will build 506 00:19:52,580 --> 00:19:53,559 on top of that. 507 00:19:54,180 --> 00:19:56,474 So that's great. So it's it's I think 508 00:19:56,474 --> 00:19:59,674 it's coming sooner than society realizes it is, 509 00:19:59,674 --> 00:20:01,615 and it will have significant advantages 510 00:20:02,075 --> 00:20:05,215 for us across, you know, all sectors, really. 511 00:20:05,275 --> 00:20:07,850 And and Stuart, earlier I was talking, to 512 00:20:07,850 --> 00:20:10,250 Margo Taylor and David Woolger about, 513 00:20:10,730 --> 00:20:11,230 magnetometry, 514 00:20:12,090 --> 00:20:13,070 quantum sensing, 515 00:20:13,850 --> 00:20:16,650 and, you you know, how successful CIRCA has 516 00:20:16,650 --> 00:20:17,150 been. 517 00:20:17,450 --> 00:20:20,250 But, you you you've just mentioned to me 518 00:20:20,250 --> 00:20:22,984 that, there's a shortage of these sensors. 519 00:20:23,764 --> 00:20:25,125 Can can you talk a bit about that 520 00:20:25,125 --> 00:20:26,804 and how that could be resolved? Yeah. I 521 00:20:26,804 --> 00:20:28,565 think in general, there's a need to make 522 00:20:28,565 --> 00:20:30,504 the quantum supply chain more robust, 523 00:20:31,524 --> 00:20:33,384 and there is a magnetometer 524 00:20:33,684 --> 00:20:35,839 sensors can do can, you know, 525 00:20:36,140 --> 00:20:38,619 achieve an awful lot of different things, but 526 00:20:38,619 --> 00:20:40,640 there isn't really the supply chain globally 527 00:20:41,579 --> 00:20:43,579 available for that at the moment. So we're 528 00:20:43,740 --> 00:20:46,380 we are actively looking as an investment company 529 00:20:46,380 --> 00:20:47,055 at others 530 00:20:52,975 --> 00:20:55,955 basically creating a better production line for them. 531 00:20:56,894 --> 00:20:59,929 Is that a a general issue in quantum 532 00:21:00,549 --> 00:21:02,549 where I suppose there's lots of great ideas 533 00:21:02,549 --> 00:21:03,450 about technology, 534 00:21:04,470 --> 00:21:07,589 but sometimes getting somebody to actually make it 535 00:21:07,589 --> 00:21:09,750 in a in quantities that are required for 536 00:21:09,750 --> 00:21:10,730 commercial applications 537 00:21:11,269 --> 00:21:13,244 can be a problem. And I'm guessing that's 538 00:21:13,325 --> 00:21:15,105 an opportunity for people like you. 539 00:21:15,805 --> 00:21:17,585 It is. Yeah. I mean, these these 540 00:21:18,204 --> 00:21:20,765 need government assistance as well to create the 541 00:21:20,765 --> 00:21:23,085 kind of facilities that you need to in 542 00:21:23,085 --> 00:21:25,724 order then to produce the pieces of equipment 543 00:21:25,724 --> 00:21:27,779 at the right, you know, size, 544 00:21:28,319 --> 00:21:29,359 cost, and, 545 00:21:29,759 --> 00:21:30,740 a level of 546 00:21:31,039 --> 00:21:31,539 sophistication. 547 00:21:32,480 --> 00:21:34,640 But, yeah, something something we're interested in. And 548 00:21:34,640 --> 00:21:36,960 and that needs to start now because you 549 00:21:36,960 --> 00:21:37,940 don't want to 550 00:21:38,400 --> 00:21:40,005 get to the point where you're ready for 551 00:21:40,005 --> 00:21:42,085 a commercial rollout, but then there's no way 552 00:21:42,085 --> 00:21:44,085 of creating the devices. Or if they are, 553 00:21:44,085 --> 00:21:46,484 they they turn out faulty and people get 554 00:21:46,484 --> 00:21:48,805 disappointed in them. Well, that's great. Thanks for 555 00:21:48,805 --> 00:21:50,585 taking the time to speak to me, Stuart. 556 00:21:50,724 --> 00:21:51,224 Pleasure. 557 00:21:56,920 --> 00:21:58,680 I'm afraid that's all the time we have 558 00:21:58,680 --> 00:22:01,740 for this week's podcast. Thanks to Margo Taylor, 559 00:22:02,039 --> 00:22:05,080 David Wilgar, and Stuart Nickel for joining me 560 00:22:05,080 --> 00:22:07,820 today. And a special thanks to our producer, 561 00:22:07,960 --> 00:22:08,775 Fred Iles. 562 00:22:09,494 --> 00:22:11,734 We'll be back again next week when our 563 00:22:11,734 --> 00:22:13,515 guest is Christophe Roussel, 564 00:22:13,894 --> 00:22:16,934 who is a condensed matter physicist who spent 565 00:22:16,934 --> 00:22:19,835 many years at IBM's lab in Zurich. 566 00:22:20,455 --> 00:22:23,480 Roussel is a past president of the European 567 00:22:23,779 --> 00:22:24,920 Physical Society, 568 00:22:25,380 --> 00:22:27,799 and he talks about the grand challenges 569 00:22:28,339 --> 00:22:29,880 facing Europe's physicists 570 00:22:30,420 --> 00:22:32,440 over the next 25 years. 571 00:22:33,220 --> 00:22:35,640 And looking a bit further into the future, 572 00:22:36,099 --> 00:22:39,914 on the 29th August, I'm in conversation with 573 00:22:39,914 --> 00:22:40,975 Elena Blachina 574 00:22:41,515 --> 00:22:43,375 who is chief scientific 575 00:22:43,674 --> 00:22:45,455 officer at Equal One. 576 00:22:45,994 --> 00:22:47,855 The Irish company has created 577 00:22:48,475 --> 00:22:52,390 hybrid quantum classical chips and was this year's 578 00:22:52,390 --> 00:22:54,890 winner of the Institute of Physics 579 00:22:55,590 --> 00:22:57,289 Quantum Business Innovation 580 00:22:57,750 --> 00:23:00,890 and Growth Prize or QBIG prize. 581 00:23:01,269 --> 00:23:04,170 So tune in for both of those conversations 582 00:23:04,789 --> 00:23:06,330 over the next few weeks.