On The Pen GLP-1 News

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On The Pen is the leading GLP-1 news podcast and platform covering obesity medicine, FDA actions, drug shortages, access policy, and the business of NuSH therapies. The podcast is in the top 1% of all podcasts globally, and On The Pen is a top Substack best-seller.


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This episode examines a serious case involving retatrutide, where an individual experienced an overdose due to improper medication administration. We discuss the critical importance of medication safety and patient safety, especially concerning prescription drugs.The discussion also touches upon a recent report of liver failure following the Foundayo launch, emphasizing the need for vigilant drug safety and thorough error analysis to prevent future incidents.

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1. 🚨 The 40mg Retatrutide Overdose Case — 0:00:02A 32-year-old self-administered gray market Retatrutide, forgot he'd dosed, injected again — hitting 40mg. The setup for the whole episode.

2. 🏥 What Actually Happened to Him (ER Visit & Why It Matters) — 0:05:02Deep dive into the published medical case: severe diarrhea, dehydration, kidney danger, and the frightening ease with which it happened.

3. ⚠️ Gray Market GLP-1s: The Real Risk Nobody's Talking About — 0:07:20How buying unregulated research peptides means guessing on purity, dose, and contents — and why that's terrifying at scale.

4. 💊 Orforglipron (Fondayo) & the Liver Failure Report — 0:13:00 (approx.)One month after Fonda's launch, a liver failure report emerges. The FDA's concerns, elevated liver enzymes in trials, and why Lilly scaled back from 45mg to 36mg in Phase 3.

5. 🔗 How These Two Stories Connect: Clinical Trials vs. the Real World — 0:16:31The through-line of the episode: drugs behave differently outside controlled settings. Peptide influencers hawking research-grade OrforglprIon pills mid-fast is the canary in the coal mine.

6. 🚪 Compounding Access Is Being Squeezed — State Boards, Lawsuits & the Gray Market Funnel — 0:19:06State medical boards in CA, RI, and KY pressuring doctors. As regulated access tightens, patients don't stop — they just shift to riskier sources.

7. 📱 Introducing the Pivot App: A GLP-1 Tracking Tool for Patients — 0:21:55Interview with Shed's Chief Product Officer Kyler Ockey about the Pivot app — dose logging, daily habit tracking, weekly check-ins, and why patient self-tracking is critical to safe GLP-1 use.


Published 2026-04-30

Eli Lilly Earnings Call Recap: Q1 2026

25 min
Open

We just got done listening to the quarter one, 2026 Eli Lilly earnings call. There was a lot of information to get into, whether you're interested in retatrutide, eloralintide, or Foundayo, and all of the numbers that were so incredible to hear. This video analyzes Eli Lilly's Q1 2026 earnings call, discussing key products like eloralintide, brenipatide, and retatrutide, providing essential finance news and stock market news for those tracking pharmaceutical companies. The presenter highlights the strong start of Foundayo's U.S. launch and reviews the Lilly Select Pipeline, touching upon the U.S. Incretin Analogs Market and broader healthcare industry trends.

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A new GLP-1 and glucagon agonist dropped data that was supposed to rival retatrutide, just without the GIP, and on the surface the results look solid. But that is not the real story. Even when people successfully lose weight, a large percentage gain it back, and for years that has been framed as a failure of discipline or willpower.

This episode breaks down new research that helps explain why that happens. A study published in EMBO Reports shows that obesity can leave lasting changes at the cellular level through epigenetics, where gene activity is altered without changing the DNA itself. Researchers found that immune cells remained in a pro inflammatory, metabolically altered state even after weight loss, with some of these changes potentially lasting for years.

In practical terms, this means the body does not simply return to a neutral baseline after weight loss. It can continue to operate as if it is still in an obese state, which helps explain why so many people feel like their body is working against them. This shifts the conversation away from personal responsibility and toward biology, reinforcing the idea that obesity is a chronic, relapsing metabolic disease.

That distinction matters because it changes how treatment should be approached. If the underlying biology does not fully reset, then short term solutions are unlikely to be effective long term. These medications may not just be tools for losing weight, but part of ongoing management for a system that retains a memory of obesity and requires continued intervention.


Major disruption hits the GLP-1 landscape as another large 503B compounding pharmacy halts production of semaglutide and tirzepatide. In this episode, we unpack what’s driving the FDA’s increased enforcement and why these shutdowns could signal a broader shift in the compounded medication market.

Joined by Sabina Hemmi from glpwinner.com, we break down the key differences between 503A and 503B pharmacies, what these changes mean for supply and patient access, and why delays in prescriptions may be on the horizon. We also dive into the growing legal battles between pharma companies and telehealth providers and what that could mean for the future of affordable GLP-1 options.

If you’re using or considering compounded GLP-1s, this episode covers what you need to know right now and what could be coming next.

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What if the most powerful obesity drug ever created ends up being the one you can’t get?

That’s the real conversation around retatrutide right now.

In this video, I break down what Eli Lilly is doing behind the scenes, and why this isn’t just about whether retatrutide is better than tirzepatide. This is about strategy. This is about access. And this is about who gets left behind.

We’re talking about:
• The push to classify retatrutide as a biologic
• Why that could mean pricing in the $7,000/month range
• How LillyDirect is changing access to tirzepatide
• The “two lane” system that could define obesity treatment going forward
• And what this means for patients already struggling to stay on GLP-1 therapies

If you’ve ever fought insurance, dealt with compounding disappearing, or felt like the system decides what you’re allowed to have… this one is for you.

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Have you ever felt stuck between “this is working” and “this isn’t enough”… with no clear path forward?



This conversation dives headfirst into one of the most controversial and least understood side effects of GLP-1 medications, what many are now calling the “Ozempic personality.” In this candid interview, Dr. Spencer Nadolsky joins On The Pen to unpack the growing reports of anhedonia, a flattening of motivation, desire, and emotional highs that some patients experience, especially at higher doses of tirzepatide and similar therapies.


What starts as a discussion about how these medications work in the brain quickly turns into something much deeper. We explore how GLP-1 and GIP receptor agonists don’t just reduce hunger, they fundamentally alter the brain’s reward system, dampening cravings, food noise, and in some cases, the very drive to seek pleasure at all. That is where the idea of the “Ozempic personality” begins to take shape, not as a diagnosis, but as a shared patient experience that is only now being taken seriously.


Dave opens up about his own journey, spending years at the highest dose and slowly realizing that while the medication gave him control over food and blood sugar, it also quietly muted parts of his identity. Hobbies faded. Motivation shifted. The highs and lows of life became more… flat. And it wasn’t until stepping away that he could see the contrast clearly.


Dr. Nadolsky brings clinical perspective to match the lived experience, explaining how this isn’t classic depression, but something more nuanced. Patients aren’t necessarily sad, they just stop wanting things. He shares how often this shows up in his practice, how he identifies it, and most importantly, how adjusting dose rather than stopping treatment altogether can restore balance.


The conversation also raises bigger questions about transparency in clinical trials, what drug companies knew about these “anti-hedonic” effects, and why something so impactful may not have been formally tracked. At the same time, both Dave and Dr. Nadolsky emphasize what matters most, these medications are still life changing, even life saving, but they are not one size fits all.


If you’ve ever felt like something changed beyond just your appetite while on a GLP-1, this is the conversation you’ve been waiting for. It puts language to an experience thousands are having but struggling to explain, and it gives you something even more important, a path forward.


Watch the full interview to understand the reality behind the “Ozempic personality,” how to recognize it, and how to work with your doctor to find your own sweet spot.

Published 2026-04-14

Foundayo GLP-1 Pill: FDA Needs More Data

20 min
Open

Orforglipron (also known as Foundayo) is one of the most promising drugs in the GLP-1 space, notably as only the second oral GLP-1 option for obesity. Unlike injectable treatments, it does not require refrigeration and is easier to scale for widespread use.

Dave highlights the ongoing questions that linger about the drugs approval as it relates to liver safety.

If you just look at the headlines, things look great for access to GLP-1 medications but for some of those already using these medications things are changing and getting tighter. Listen in as Dave breaks down the news of the week and puts it all in context.


Topics:

The GLP-1 paradox, Rise of telehealth powerhouses, FDA guidance on compounding, Enforcement risks and industry impact, Peptide imports and gray market concerns, New branded drug developments, Expansion of oral GLP-1 medications, New oral drug launches, Where the market is heading.

Are you on tirzepatide or semaglutide and struggled with inconsistent weight loss and side effects? On this episode of On The Pen, Dave Knapp and Dr. Ian Ellis dive into the surprising variability of GLP-1 dosing (retatrutide, tirzepatide), even when the weekly dose remains the same. We explore how these subtle dosage changes can lead to frustrating glp-1 side effects and why many individuals eventually give up on their weight loss medication. This new way of thinking about glp-1 dosing could change the obesity medicine game. Referenced Links: http://www.OTPLinks.com00:00 Why most GLP-1 users are never on the same dose twice01:55 Dr. Ian's background: trainer, nutritionist, ER physician04:00 His obsessive relationship with food and body composition07:45 The two impossible choices: obsession or obesity10:12 How medical school destroyed his health10:25 A colleague mentions Ozempic for the first time11:35 His first dose and what real satiety feels like13:00 Why the same dose felt worse every single week15:00 30 lbs lost but the body scan results were horrifying17:30 Why elderly patients are especially at risk on GLP-1s18:35 Patient case: Pat May, 310 lbs, lost over 100 lbs20:45 Semaglutide half-life and dose stacking explained24:50 The therapeutic window and finding your ideal level26:30 Why the dosing protocol was built for trials not people28:00 You are never on the same drug level twice29:00 Patient case: Mary Alice lost 30 lbs below the starting dose32:00 The math behind calculating your precise GLP-1 level35:00 The VoaFit app and making precision dosing scalable36:00 Their patients lost more weight using half the medicine39:30 Why 40 to 70 percent of people quit GLP-1s42:00 Compounding pharmacies and the case for flexible dosing46:00 Using GLP-1 as a thermostat dial for your appetite56:45 Where precision dosing is available now58:30 Beyond GLP-1s: applying this to testosterone and more1:05:30 Why hitting the dose ceiling kills long-term results1:07:00 Dr. Ian's outcome: off GLP-1s completely1:10:00 Fixing a broken one-size-fits-all dosing paradigm1:13:00 How to find Dr. Ian Ellis and VoaFit

Published 2026-03-31

Wegovy Price Drop Exposes a Bigger Problem

18 min
Open

A major shift in obesity treatment is underway following a surprising pricing move that could change how patients access care. This episode explores the growing divide between traditional healthcare and alternative pathways, the real tradeoffs behind cost and safety, and what the future may hold for medications, access, and long term health.


TOPICS:

Wegovy Price Drop Changes EverythingWhat This Podcast CoversNew Savings Programs ExplainedWhy This Is Bigger Than PriceThe Broken Healthcare SystemRise of Telehealth & CompoundingThe New Parallel System of CareGray Market vs Medical AccessSafety vs Strength DebateRisks of Unregulated MedicationsWhy Long-Term Support MattersGray Market Supply ConcernsPharma Pressure & RegulationWhat Happens If Access ChangesTrust Issues with the System The Core Question: Safety or PowerAre OTC GLP-1s Coming?New Oral Drugs & NexboundWhy Pills Could Change EverythingAccess vs CareGLP-1s as Longevity DrugsEli Lilly’s Big Bet on the FutureThe Next 5–10 Years

Access to compounded and research-grade GLP-1s may be tightening, as comments from Robert F. Kennedy Jr. signal increased enforcement and a push back toward branded medications. At the same time, new data on retatrutide shows powerful results for people with type 2 diabetes, while drug companies are already developing next-generation therapies beyond GLP-1s.


Todat's topics:

The Throttling of Compounded GLP-1sFDA vs Telehealth, What’s Really HappeningThe Truth About “Research Peptides”The Rule That Created the Black Market If You Rely on This, Here’s What’s ComingWhy They Want You Back on Branded DrugsRetatrutide Might Be the Most Powerful YetThe Data That Changes Everything (Diabetes + Weight Loss)What Comes After GLP-1s, The Next Wave

On The Pen breaks down the latest GLP-1 news, compounded semaglutide updates, tirzepatide controversy, FDA and DDC list developments, Novo Nordisk findings, Eli Lilly B12 tirzepatide concerns, and new oral obesity drug data from Structure Therapeutics. If you follow obesity medicine, weight loss drugs, peptide news, semaglutide, Zepbound, Wegovy, Ozempic, Mounjaro, and patient advocacy, this episode is for you.


WAYS TO SUPPORT MY WORK ⬇️http://www.otplinks.com00:00 Massive compound shakeup00:00:43 Why compound users need this00:01:25 Sponsor, Shed obesity care00:02:11 Breaking news changed everything00:02:28 OTP semaglutide exclusive00:03:28 DDC list explained00:04:24 Novo’s lab findings00:09:57 302% dose shocker00:13:03 Catalent’s contamination mess00:16:33 Lilly’s B12 tirzepatide bombshell00:19:34 Is the molecule changing?00:21:46 New oral GLP-1 contender

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On this episode of the podcast, host Dave Knapp breaks down the latest updates on potential GLP-1 receptor agonists coverage for people on Medicare living with obesity. With new guidance released by the Centers for Medicare & Medicaid Services, the episode explains how two upcoming federal programs—the Bridge Program (2026) and the Balance Model (2027)—could expand access to medications like Zepbound and Wegovy.

Listeners will learn who may qualify, how the proposed $50 monthly cost could work during the temporary Bridge Program, and why coverage could change once insurance plans become involved in 2027. The episode also outlines the role of the proposed Treat and Reduce Obesity Act and why long-term Medicare coverage still depends on congressional action.

If you or a loved one are on Medicare and curious about access to GLP-1 medications for obesity treatment, this episode explains the key timelines, eligibility criteria, and practical steps patients should take with their doctors.

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Thank you for tuning in! If you found this content valuable, make sure to like, share, and subscribe to my youtube channel for more updates on GLP-1, obesity, type 2 diabetes, and the latest news on Mounjaro, Zepbound, Wegovy, and Ozempic. Stay informed and entertained with my unique blend of breaking news, humor, and my personal journey. For in-depth articles and resources, visit onthepen.com.

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Episode Summary (Short Version):

This week on On The Pen, Dave breaks down the rapid changes reshaping GLP-1 access — from new federal reforms targeting PBMs and possible FDA limits on compounded semaglutide, to Walgreens and Amazon launching cash-pay weight loss clinics.

As insurance denials continue and out-of-pocket costs rise, patients are stuck between a shifting policy landscape and a growing direct-to-consumer market. Plus, an AI-designed oral GLP-1 enters Phase 3 trials, signaling how fast obesity medicine is evolving.

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Decoding GLP-1 Book
Decoding GLP-1: A Guide for Friends and Family of Those On The Pen
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Thank you for tuning in! If you found this content valuable, make sure to like, share, and subscribe to my youtube channel for more updates on GLP-1, obesity, type 2 diabetes, and the latest news on Mounjaro, Zepbound, Wegovy, and Ozempic. Stay informed and entertained with my unique blend of breaking news, humor, and my personal journey. For in-depth articles and resources, visit onthepen.com.

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This episode unpacks Novo’s aggressive price cuts, Lilly’s head to head trial win, and the emerging triple agonist race, revealing how pricing strategy and next generation data are colliding in a full scale GLP-1 market war.

00:00 – Cold Open: Lilly vs Novo Shock Timing
Dave opens with the bombshell that Novo funded a tirzepatide trial while simultaneously announcing major price cuts to Wegovy and Ozempic, setting up a strategic chess match.

03:20 – Novo Nordisk Price Cuts Explained
Deep dive into Novo’s plan to cut list prices by up to 50% and what that actually means for formulary power, PBMs, and competitive positioning.

07:25 – Tirzepatide vs Semaglutide Head to Head Trial
Breakdown of the direct comparison study showing stronger weight loss with tirzepatide and what that means clinically and commercially.

11:55 – Market Reaction and Strategic Implications
Discussion of stock movement, competitive signaling, and how Novo’s pricing move may blunt Lilly’s trial victory.

14:25 – Novo Triple Agonist Data Drops
Shift into Novo’s early phase data on its triple agonist candidate and how it compares conceptually to existing dual agonists.

16:00 – Comparing Novo’s Triple to Retatrutide
Analysis of weight loss percentages versus Lilly’s retatrutide data and the caution required when comparing across trials.

18:15 – The Triple Agonist Era
Broader conversation about whether triple agonism consistently pushes weight loss higher and what durability may look like long term.

20:00 – Clinical Trial Results vs Real World Reality
Reminder that clinical trial outcomes do not automatically translate to everyday patient experience.

22:30 – Data Refresher on Allurion Ballon Approval
Quick recap of the headline numbers and strategic landscape as innovation and pricing

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Decoding GLP-1 Book
Decoding GLP-1: A Guide for Friends and Family of Those On The Pen
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Thank you for tuning in! If you found this content valuable, make sure to like, share, and subscribe to my youtube channel for more updates on GLP-1, obesity, type 2 diabetes, and the latest news on Mounjaro, Zepbound, Wegovy, and Ozempic. Stay informed and entertained with my unique blend of breaking news, humor, and my personal journey. For in-depth articles and resources, visit onthepen.com.

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Wegovy’s new 7.2 mg dose—three times higher than the current max—has just been approved in the EU, with U.S. approval expected soon. But now that Wegovy matches Zepbound on weight loss, the real question isn’t which drug helps you lose more weight—it’s which one treats your underlying metabolic disease more effectively.

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Decoding GLP-1 Book
Decoding GLP-1: A Guide for Friends and Family of Those On The Pen
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MY WORK RELIES ON YOUR GENEROSITY, WAYS TO SUPPORT:
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📲 Contact Me: dave@onthepen.com

Thank you for tuning in! If you found this content valuable, make sure to like, share, and subscribe to my youtube channel for more updates on GLP-1, obesity, type 2 diabetes, and the latest news on Mounjaro, Zepbound, Wegovy, and Ozempic. Stay informed and entertained with my unique blend of breaking news, humor, and my personal journey. For in-depth articles and resources, visit onthepen.com.

Published 2026-02-10

Compound Tirzepatide: Time to Stock Up?

31 min
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This week on The Weekly Dose, Dave Knapp breaks down the biggest questions shaking up the GLP-1 world. From whether patients should be stocking up on compounded injectables, to what Eli Lilly’s earnings call revealed about Zepbound QuickPens, refill rules, and the long-awaited retatrutide timeline, this episode covers it all. Dave also unpacks FDA enforcement signals, the escalating tension between Big Pharma and compounders, the Hims & Hers controversy, and what recent lawsuits and Super Bowl ads tell us about where obesity treatment is headed next. Clear context, real-world implications, and what patients should be discussing with their doctors right now.

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Decoding GLP-1 Book
Decoding GLP-1: A Guide for Friends and Family of Those On The Pen
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Thank you for tuning in! If you found this content valuable, make sure to like, share, and subscribe to my youtube channel for more updates on GLP-1, obesity, type 2 diabetes, and the latest news on Mounjaro, Zepbound, Wegovy, and Ozempic. Stay informed and entertained with my unique blend of breaking news, humor, and my personal journey. For in-depth articles and resources, visit onthepen.com.

Published 2026-02-04

Eli Lilly Earnings Call Q4 2025 Recap

21 min
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This week on On The Pen: The Weekly Dose, Dave breaks down one of the most consequential Eli Lilly earnings calls to date. We dive into major updates on retatrutide, new Phase 3 timelines, and why Lilly is positioning next-generation GLP-1 and GIP therapies far beyond obesity, including osteoarthritis, sleep apnea, addiction, and mental health. From manufacturing scale and Medicare access to brand-new molecules like bernipotide and amylin-based therapies, this episode explores what the future of incretin medicine could really look like for patients.

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Decoding GLP-1 Book
Decoding GLP-1: A Guide for Friends and Family of Those On The Pen
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Thank you for tuning in! If you found this content valuable, make sure to like, share, and subscribe to my youtube channel for more updates on GLP-1, obesity, type 2 diabetes, and the latest news on Mounjaro, Zepbound, Wegovy, and Ozempic. Stay informed and entertained with my unique blend of breaking news, humor, and my personal journey. For in-depth articles and resources, visit onthepen.com.

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This week on On The Pen: The Weekly Dose, we break down Pfizer’s $10 billion bet on obesity medicine and whether it’s shaping up to be a smart move or a costly miss. We dig into newly released Phase 2b data from Pfizer’s once-monthly GLP-1 candidate (formerly Metsera’s asset), what the results actually show, and how it stacks up in an increasingly crowded field that includes Novo Nordisk, Eli Lilly, and next-gen combination therapies. We also talk strategy, maintenance dosing, combination GLP-1 + amylin approaches, pricing pressures, cash-pay access, and what this all means for patients navigating a rapidly changing obesity treatment landscape. Plus, earnings week insights, where Pfizer may be headed next, and why pricing and access, not just weight-loss percentages, may end up being the real disruptors.

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Decoding GLP-1 Book
Decoding GLP-1: A Guide for Friends and Family of Those On The Pen
Buy Here: https://amzn.to/3Dc66d4

MY WORK RELIES ON YOUR GENEROSITY, WAYS TO SUPPORT:
Venmo: OnThePen
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📲 Contact Me: dave@onthepen.com

Thank you for tuning in! If you found this content valuable, make sure to like, share, and subscribe to my youtube channel for more updates on GLP-1, obesity, type 2 diabetes, and the latest news on Mounjaro, Zepbound, Wegovy, and Ozempic. Stay informed and entertained with my unique blend of breaking news, humor, and my personal journey. For in-depth articles and resources, visit onthepen.com.

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Can Zepbound treat PCOS? That's the question this clinical trial will seek to answer, and we cover it exclusively on this week's On The Pen podcast.

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Decoding GLP-1 Book
Decoding GLP-1: A Guide for Friends and Family of Those On The Pen
Buy Here: https://amzn.to/3Dc66d4

MY WORK RELIES ON YOUR GENEROSITY, WAYS TO SUPPORT:
Venmo: OnThePen
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📲 Contact Me: dave@onthepen.com

Thank you for tuning in! If you found this content valuable, make sure to like, share, and subscribe to my youtube channel for more updates on GLP-1, obesity, type 2 diabetes, and the latest news on Mounjaro, Zepbound, Wegovy, and Ozempic. Stay informed and entertained with my unique blend of breaking news, humor, and my personal journey. For in-depth articles and resources, visit onthepen.com.

Published 2026-01-20

Over The Counter GLP-1 Prediction

21 min
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In this episode of On The Pen: The Weekly Dose, Dave Knapp breaks down why the idea of over-the-counter GLP-1 medications isn’t radical speculation, it’s a pattern already in motion. Drawing on FDA signals, past regulatory precedent with Orlistat, recent pricing negotiations, softened safety language, and public comments from pharmaceutical executives, Dave lays out the case that low-dose oral GLP-1s could be the first step toward OTC access. This episode connects the dots between regulation, access, pricing, and normalization of obesity treatment, and explains why the people laughing today may be asking how they missed it tomorrow.

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Shantanu Gaur, CEO of Allurion, returns to the podcast to break down their swallowable inflatable weight loss balloon, how it works, who it is for, how much it is expected to cost, and when patients can realistically expect access.

We talk real world weight loss results, safety, availability in the US, and how Allurion fits into the broader obesity treatment conversation alongside GLP-1 medications and bariatric options.

This is a clear, no hype discussion for patients who want more tools and better choices in obesity care.

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This week on On The Pen, we break down a rare FDA walk-back on GLP-1 safety labeling, major pharma signals coming out of JPM 2026, and the growing tension between patient access and legislative efforts that could restrict compounding. We discuss what these developments actually mean for patients, why access—not innovation alone—will determine the future of obesity medicine, and how the OTP community continues to play a critical role in shaping this landscape.

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Published 2026-01-06

Wegovy Pens Recalled & Wegovy Pill Launch

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This episode opens the year with one of the most consequential—and complicated—weeks in GLP-1 obesity medicine.

We break down three stories that, taken together, reveal why patients are increasingly reading past headlines and demanding accountability from the industry.

First, we examine early-phase trial data from Arrowhead Pharmaceuticals, after headlines claimed its experimental INHBE-targeting therapy “nearly doubled” the weight loss of Zepbound. We walk through what the data actually showed, why the comparison was misleading, how trial design and dosing matter, and why Phase 1 results should never be treated as superiority claims.

Next, we turn to a major access milestone: the official launch of oral Wegovy, the first FDA-approved GLP-1 pill for obesity from Novo Nordisk. We discuss how this pill differs from compounded oral semaglutide, why its pricing strategy is so disruptive, and what this launch means for people who have avoided injectable medications. We also explore how direct-to-consumer access, telehealth partnerships, and retail pharmacy distribution signal a broader shift in how obesity care is being delivered.

Finally, we address the most ironic—and uncomfortable—story of the week: manufacturing quality concerns involving branded Wegovy pens, reported to include biological particulate matter, at the same time Novo Nordisk continues a years-long public and legal campaign against compounded GLP-1 medications on safety grounds. We discuss FDA inspection history, the acquisition of Catalent, and why credibility depends on consistency—especially when millions of patients are paying close attention.

This episode isn’t anti-pharma or pharma-friendly. It’s patient-first.
And it asks a simple question: Who do we trust when science, marketing, access, and manufacturing all collide at once?

Episode Timestamps

00:00 — Why this first episode of 2026 matters
02:10 — Hair found in Wegovy pens and why patients notice hypocrisy
06:15 — Arrowhead trial headlines vs. what the data actually shows
11:40 — Why tirzepatide dosing and trial design matter
17:30 — What INHBE targeting may actually be good for (and what it’s not)
21:45 — Sponsor: SHED and access pathways for obesity care
25:10 — Oral Wegovy officially launches: what’s different this time
30:20 — How the Wegovy pill works and why bioavailability matters
35:40 — Pricing, telehealth, Costco, and direct-to-consumer access
41:50 — Why pills lower barriers for millions of patients
46:10 — Manu

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Pharma Influence & Why Patient Voices Matter
Lobbying Power: Eli Lilly, Novo Nordisk, and Government Access
Why GLP-1 Medication Access Is at Risk
Introducing Sabina Hemi & the Mission of GLP Winner
Why Compounded GLP-1s Matter for Real Patients
The Federal “Safe Drugs” Bill: What It Claims vs What It Does
Why This Bill Raises Red Flags for Patients
What Real Compounding Safety Reform Would Look Like
How Compounding Pharmacies Are Actually Regulated Today
Prescription Reporting vs Patient Safety
Is This Bill About Safety or Litigation Data?
Dose Flexibility, Personalized Medicine, and Compounding
Florida SB 860: A Direct Threat to Compounded GLP-1s
Why Florida Compounding Impacts the Entire Country
Why Obesity Medications Are Being Singled Out
Active Pharmaceutical Ingredients (API): What Patients Should Know
FDA Oversight, the “Green List,” and State Overreach
Why Florida’s API & COA Requirements Don’t Add Up
FDA Inspection Backlogs & Impossible Compliance Standards
Branded Drug Safety Issues vs Compounding Scrutiny
Catalent, Novo Nordisk, and Manufacturing Concerns
Counterfeit Ozempic: The Overlooked Safety Crisis
Why Supply Chain Integrity Should Be the Priority
What Patients Can Do Right Now
Petitions, Advocacy, and Making Your Voice Heard
Florida Residents: Why Local Action Matters
Final Thoughts on Access, Power, and Patient Advocacy

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Retatrutide is years away from FDA approval and yet the fight over access, price, control of this medication is already well underway. That's what this podcast is going to be about today. There's well over a hundred thousand people by my estimates who are already on some form of this medication today. And that should tell you enough about how disruptive this molecule is and will be. It is a game changer among game changer. We've been talking about it for three years here at On The Pen, well before any of your favorite gym bros were talking about Retatrutide. We were talking about Reta, who tried Retatrutide here at On The Pen. And that's because we identified this triple agonist as a game changer among game changers. So This is going to be a very Retatrutide heavy episode, and so I hope you'll join us and stick with us if this is a topic you enjoy, because I think this is really going to effectively lay the groundwork for what accessibility to this medication will look like. So let's get into it.

Welcome to the On The Pen Podcast with your host, Dave Knapp. Welcome to the On The Pen, the weekly dose podcast. This is our weekly roundup in incretin memetic news. And frankly, there's no news that is bigger than Reta-Trutide news. Just find me any news that is bigger than the data that we got on Reta-Trutide. Now, we already did a video about the Triumph Phase II clinical trials that we got in osteoarthritis of the knee. You can go back and check out that video if you'd like more data. So we're not gonna super... rehash the data. We'll go over at a high level what the data showed us. We're not going to go over how the medicine works, because by now we all know that it's the triple agonist, right? If terzapatide was a dual agonist, GLP-GIP, Retatrutide is the triple agonist that adds to it a glucagon component, which is absolutely just shredding, shredding liver fat. It is absolutely revving up people's metabolism and showing a tremendous amount of weight loss.

So let's get into what the weight loss looked like in this first trial, because there are longer obesity trials where, where the primary outcome is the weight loss this was again a specific trial in measuring pain reduction in folks with osteoarthritis of the knee but check out these numbers these are placebo adjusted meaning it's taking the two percent out that people lost on placebo but looking at these numbers Folks on one milligram over forty eight weeks lost seventeen percent. They bumped up to four milligrams. Those folks lost twenty two percent. So right there at th

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0:00 Welcome & today’s focus: Retatrutide and “chasing the biggest number”
1:11 On The Pen intro, live schedule (Mon/Wed/Fri) & housekeeping
2:10 How Dave first heard about retatrutide (work trip, early phase 1 data)
3:35 Flashback clip: early excitement about retatrutide phase 3 trials
4:40 Why this new retatrutide data feels different for obesity medicine
5:32 TRIUMPH-4 trial overview: obesity + knee osteoarthritis population
7:00 Headline results: 28.7% average weight loss, surgery-level efficacy
8:47 Breaking down weight loss by dose (9 mg vs 12 mg; 25–35% loss rates)
11:05 What “efficacy estimate” really means (race-track analogy)
13:28 Real-world view: treatment-regimen estimate (20–23.7%) vs trial ideal
15:40 Mechanism refresher: GIP, GLP-1, glucagon and why RETA differs from TIRZ
18:05 Side effects, dysesthesia/allodynia & who stopped treatment (BMI differences)
21:02 Why the lower doses matter & who actually needs 30% weight loss
24:15 From “just make the scale go down” to quality of weight loss & body composition
28:05 Future focus: health, longevity, and peptides beyond hitting goal weight
30:40 Viewer Q&A: combining RETA + TIRZ, amylin (eloralintide) combos & “talk to your doctor”
34:38 How retatrutide changes the next decade of obesity treatment conversations
37:22 News update: high-dose Wegovy 7.2 mg approval in the EU & US outlook
40:55 Orforglipron oral GLP-1: liver-signal concerns & fast-track FDA review
45:20 Why small-molecule oral GLP-1s aren’t the same as injectable peptides
48:40 New topic: Indiana “Safe Drug Act of 2025” and why Dave is concerned
51:02 Production caps, “essentially a copy” language & shifting power from prescribers to FDA
54:28 How the bill undermines personalization while ignoring real safety tools
57:05 Safety theater vs real safeguards: API sourcing, sterility & adverse-event reporting
59:45 Who actually gets hit: compliant 503A/503B compounders vs existing bad actors
1:02:05 Call to action: petition at otplinks.com & why patient voices matter
1:05:10 Change.org impact, media attention & centering the patient perspective
1:07:30 Final Q&A, subscribe, obesity.news email list & closing thanks

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Episode Timeline & Main Topics

00:00 — Opening & Community Update
• First week doing the podcast fully live thanks to the On The Pen community
• Overview of why this week’s news is a major turning point in obesity medicine

02:30 — Introducing the “One-and-Done” Obesity Drug (Wave Life Sciences)
• WVE-007 early data drops
• Why this therapy is unlike GLP-1s or any nutrient-stimulated hormone
• Fat loss results and lean-mass increase

06:30 — How Wave-007 Works: INHBE Gene Silencing
• Mechanism behind visceral fat reduction
• Why this shifts the field toward “quality of weight loss”

09:15 — Why Lean-Mass Preservation Matters
• Current GLP-1 medications and muscle loss
• Why women dominate trial enrollment and the larger implications
• Medicare patients and the coming wave of GLP-1 coverage

13:45 — The Future of Maintenance Therapies
• Fractyl Health Revita results
• Lilly’s orforglipron maintenance design
• Why “holding the line” after GLP-1 therapy is the next major category

17:30 — Amylin Agonists: Cagrelintide vs. Eloralintide
• Novo’s delays and the strategy behind them
• Lilly’s surprising phase 2 results (up to 20% weight loss)
• Combination therapies with tirzepatide or retatrutide

22:30 — FDA Pipeline Acceleration
• Potential removal of traditional phase 3 trials
• How this speeds up the arrival of next-generation therapies

24:15 — Oral GLP-1 Small Molecules (Structure Therapeutics)
• Alaniglipron data and the stock surge
• Comparisons to orforglipron and past failures like denuglipron
• Why Dave remains skeptical

28:40 — Sponsor Break: Shed & Shapa
• Access, coaching, and patient support
• Using a numberless scale to build a healthier relationship with weight tracking

31:10 — Counterfeit Ozempic Warning
• New fake lot discovered in U.S. pharmacies
• How to identify counterfeit pens
• Why this should be a national headline
• The broader question of drug supply-chain vulnerability

36:00 — Closing Thoughts on the Future of Obesity Medicine
• Moving from “more weight loss” to “better weight loss”
• Why the field is closer than ever to reshaping obesity as a disease
• Gratitude for the community making full-time coverage possible

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Topics We Cover:

00:00 – New data from Harvard/Mass General may classify nearly 70% of adults as having obesity
03:00 – A new oral triple agonist shows record-setting absorption rates
07:00 – Fractal Health’s Revita procedure: weight maintenance after stopping GLP-1s
12:00 – Zepbound vial prices drop (full breakdown by dose)
16:00 – Dave’s personal experience switching off Mounjaro and intense hunger return
22:00 – Novo Nordisk’s EVOKE/EVOKE+ Alzheimer’s trial: what the data really means
29:00 – Why GLP-1 neurological research is just getting started
33:00 – Updates on access, partners, and major news coming soon for Medicare patients

If you’re on Wegovy, Mounjaro, Zepbound, Saxenda, Trulicity, or compounded versions, this episode gives you the insight and context you need to have more competent and confident conversations with your doctor.

Bullet Point Summary of the Podcast Episode

  1. New Obesity Measurement Data (Harvard/Mass General Study)

Harvard and Mass General propose adding waist circumference to BMI to better diagnose obesity.

Traditional BMI misses key factors like muscle mass and body composition.

Using the updated measure, Americans classified as obese jumps from ~43% to almost 69%.

This means 7 out of 10 U.S. adults would now qualify as having the disease of obesity.

Dave notes this validates many people who “feel” metabolically unwell despite a “normal” BMI.

Reinforces his claim that “most people should be talking to their doctors about GLP-1s.”

  1. New Oral Triple Agonist (Ascletis – ASC41/ASC? Molecule)

From Ascletis (A-S-C-L-E-T-I-S), developing an oral triple agonist targeting:

GLP-1

GIP

Glucagon

Similar in mechanism to retatrutide, expected around 2027.

Preclinical (animal) data show stunning results:

Oral bioavailability of 4.2%

9× higher than tirzepatide

30× higher than oral semaglutide

6× higher than oral retatrutide

57× greater drug exposure than oral retatrutide

Half-life ~56 hours

Stronger receptor activation than retatrutide in vitro

Suggests potential for the first powerful oral triple agonist—worth watching.

️ 3. Discussion of the Gray Market / TikTok Experience

Dave briefly recounts losing his TikTok account and landing in an algorithm filled with teenagers promoting gray-market “retatrutide.”

Expresses concern over unregulated peptide sales, especially to minors.

  1. Fract

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Published 2025-11-18

Wegovy GLP-1 Price Novo Blinks First

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Published 2025-11-11

GLP-1 State of the Union

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💉 Story 1 — Fractyl Health’s One-and-Done Gene Therapy for Obesity
Fractyl Health just dropped preclinical results showing their GLP-1 + GIP gene therapy candidate RJVA-002 produced almost 30% weight loss in mice after a single dose. I sat down with Dr. Harith Rajagopalan, CEO of Fractyl Health, to talk about how this new Rejuva® platform works, what it means for people living with obesity and type 2 diabetes, and why gene therapy might be the future of metabolic care.

🏛️ Story 2 — Medicare Coverage for GLP-1s? Dr. Oz Drops a Hint
At the Aspen Institute, CMS Administrator Dr. Mehmet Oz said even a comment on GLP-1 coverage would be “market moving.” We break down what that means, why the Trump administration shelved a rule that would’ve added obesity meds to Medicare coverage, and how that decision might now be a bargaining chip to lower drug prices in exchange for tougher enforcement on compounding.

⚖️ Story 3 — The Retatrutide Ruling and the Future of Compounded Access
A federal judge ruled the FDA acted “arbitrarily and capriciously” when it rejected Lilly’s bid to classify retatrutide as a biologic. That may sound technical, but if the FDA changes its stance, it could have huge implications for tirzepatide (Zepbound, Mounjaro) and semaglutide (Wegovy, Ozempic)—especially when it comes to compounding and patient access.

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In this week's episode we unpack some Orforglipron breaking news, plus a preview of this week's Eli Lilly VS Mochi lawsuit hearing.

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Published 2025-08-19

Ozempic Price Cut + New Obesity Pill Data

34 min
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This week, Dave covers massive GLP-1 news out of Connecticut, a new GLP-1 heart study that changes the conversation, and a big OTP event opportunity announcement!

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At 650 pounds, GLP-1 injections helped give Jamie His Life Back.Get Our Newsletter and Help us Grow!https://www.obesity.newsSupport OTP (all our links):https://linktr.ee/manonthemounjaro

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https://www.linktr.ee/manonthemounjaroOzempic rare eye disease updateThe the race for once monthly dosingBig insurance wins incoming?!

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Dave discussed the latest update in the OFA vs FDA compound tirzepatide battle, as well as this weeks news in obesity medicine.

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CVS announces major partnership with Novo Nordisk as Lilly announces Q! 2025 earnings. Dave covers it all in today's breakdown.

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Sign up here and use code “OTP10” to save 10%
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WHY I TRUST INTEGRATIVE PEPTIDES:
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Thank you for tuning in! If you found this content valuable, make sure to like, share, and subscribe to my youtube channel for more updates on GLP-1, obesity, type 2 diabetes, and the latest news on Mounjaro, Zepbound, Wegovy, and Ozempic. Stay informed and entertained with my unique blend of breaking news, humor, and my personal journey. For in-depth articles and resources, visit my website at onthepen.com.

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Decoding GLP-1 Book
Decoding GLP-1: A Guide for Friends and Family of Those On The Pen
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Thank you for tuning in! If you found this content valuable, make sure to like, share, and subscribe to my youtube channel for more updates on GLP-1, obesity, type 2 diabetes, and the latest news on Mounjaro, Zepbound, Wegovy, and Ozempic. Stay informed and entertained with my unique blend of breaking news, humor, and my personal journey. For in-depth articles and resources, visit onthepen.com.

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Thank you for tuning in! If you found this content valuable, make sure to like, share, and subscribe to my youtube channel for more updates on GLP-1, obesity, type 2 diabetes, and the latest news on Mounjaro, Zepbound, Wegovy, and Ozempic. Stay informed and entertained with my unique blend of breaking news, humor, and my personal journey. For in-depth articles and resources, visit onthepen.com.

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The Knapp family was featured in a health.com video!
Watch it Here: https://www.health.com/beyond-obesity-glp1-8685599

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📕 GET MY BOOK!
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Decoding GLP-1: A Guide for Friends and Family of Those On The Pen
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MY WORK RELIES ON YOUR GENEROSITY, WAYS TO SUPPORT:
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Thank you for tuning in! If you found this content valuable, make sure to like, share, and subscribe to my youtube channel for more updates on GLP-1, obesity, type 2 diabetes, and the latest news on Mounjaro, Zepbound, Wegovy, and Ozempic. Stay informed and entertained with my unique blend of breaking news, humor, and my personal journey. For in-depth articles and resources, visit onthepen.com.

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The Knapp family was featured in a health.com video!
Watch it Here: https://www.health.com/beyond-obesity-glp1-8685599

WAYS TO SUPPORT MY WORK ⬇️

💊 OVER THE COUNTER ORAL PEPTIDE SUPPLIMENTS:
BPC-157 // Can’t Weight // TB4-FRAG // KPV
Sign up here and use code “OTP10” to save 10%
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WHY I TRUST INTEGRATIVE PEPTIDES:
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🧑‍⚕️Trusted and Sold By Doctors and Clinics all over the USA

📕 GET MY BOOK!
Decoding GLP-1: A Guide for Friends and Family of Those On The Pen By Dave Knapp
https://amzn.to/4gAXrz4

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Thank you for tuning in! If you found this content valuable, make sure to like, share, and subscribe to my youtube channel for more updates on GLP-1, obesity, type 2 diabetes, and the latest news on Mounjaro, Zepbound, Wegovy, and Ozempic. Stay informed and entertained with my unique blend of breaking news, humor, and my personal journey. For in-depth articles and resources, visit onthepen.com.

Send a text

The Knapp family was featured in a health.com video!
Watch it Here: https://www.health.com/beyond-obesity-glp1-8685599

WAYS TO SUPPORT MY WORK ⬇️

💊 OVER THE COUNTER ORAL PEPTIDE SUPPLIMENTS:
BPC-157 // Can’t Weight // TB4-FRAG // KPV
Sign up here and use code “OTP10” to save 10%
https://integrativepeptides.com/OTP

WHY I TRUST INTEGRATIVE PEPTIDES:
🇺🇸 Made in the USA
📋 CGMP Compliant (FDA oversight of their products)
🧑‍⚕️Trusted and Sold By Doctors and Clinics all over the USA

📕 GET MY BOOK!
Decoding GLP-1: A Guide for Friends and Family of Those On The Pen By Dave Knapp
https://amzn.to/4gAXrz4

SOCIALS:
📸 : https://www.instagram.com/onthepen.official/profilecard/?igsh=dTRhY3JkYWo1bTIx
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Decoding GLP-1 Book
Decoding GLP-1: A Guide for Friends and Family of Those On The Pen
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MY WORK RELIES ON YOUR GENEROSITY, WAYS TO SUPPORT:
Venmo: OnThePen
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Thank you for tuning in! If you found this content valuable, make sure to like, share, and subscribe to my youtube channel for more updates on GLP-1, obesity, type 2 diabetes, and the latest news on Mounjaro, Zepbound, Wegovy, and Ozempic. Stay informed and entertained with my unique blend of breaking news, humor, and my personal journey. For in-depth articles and resources, visit onthepen.com.

Send a text

WAYS TO SUPPORT MY WORK ⬇️

💊 OVER THE COUNTER ORAL PEPTIDE SUPPLIMENTS:
BPC-157 // Can’t Weight // TB4-FRAG // KPV
Sign up here and use code “OTP10” to save 10%
https://integrativepeptides.com/OTP

WHY I TRUST INTEGRATIVE PEPTIDES:
🇺🇸 Made in the USA
📋 CGMP Compliant (FDA oversight of their products)
🧑‍⚕️Trusted and Sold By Doctors and Clinics all over the USA

📕 GET MY BOOK!
Decoding GLP-1: A Guide for Friends and Family of Those On The Pen By Dave Knapp
https://amzn.to/4gAXrz4

SOCIALS:
📸 : https://www.instagram.com/onthepen.official/profilecard/?igsh=dTRhY3JkYWo1bTIx
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👾: https://discord.gg/ZHeUh7WV
📺: https://youtube.com/@ManOnTheMounjaro?feature=shared
❌: https://x.com/manonthepen?s=21
💻: https://www.onthepen.com

#ozempic #mounjaro #onthepen

🤝 Visit Our Sponsors!
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Decoding GLP-1 Book
Decoding GLP-1: A Guide for Friends and Family of Those On The Pen
Buy Here: https://amzn.to/3Dc66d4

MY WORK RELIES ON YOUR GENEROSITY, WAYS TO SUPPORT:
Venmo: OnThePen
Ca$h App: ManOnMounjaro

BECOME A MEMBER:
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Thank you for tuning in! If you found this content valuable, make sure to like, share, and subscribe to my youtube channel for more updates on GLP-1, obesity, type 2 diabetes, and the latest news on Mounjaro, Zepbound, Wegovy, and Ozempic. Stay informed and entertained with my unique blend of breaking news, humor, and my personal journey. For in-depth articles and resources, visit onthepen.com.

Send a text

WAYS TO SUPPORT MY WORK ⬇️

💊 OVER THE COUNTER ORAL PEPTIDE SUPPLIMENTS:
BPC-157 // Can’t Weight // TB4-FRAG // KPV
Sign up here and use code “OTP10” to save 10%
https://integrativepeptides.com/OTP

WHY I TRUST INTEGRATIVE PEPTIDES:
🇺🇸 Made in the USA
📋 CGMP Compliant (FDA oversight of their products)
🧑‍⚕️Trusted and Sold By Doctors and Clinics all over the USA

📕 GET MY BOOK!
Decoding GLP-1: A Guide for Friends and Family of Those On The Pen By Dave Knapp
https://amzn.to/4gAXrz4

SOCIALS:
📸 : https://www.instagram.com/onthepen.official/profilecard/?igsh=dTRhY3JkYWo1bTIx
🇨🇳: https://www.tiktok.com/@manonthemounjaro?_t=ZP-8sr5PrUuPQl&_r=1
👾: https://discord.gg/ZHeUh7WV
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❌: https://x.com/manonthepen?s=21
💻: https://www.onthepen.com

🤝 Visit Our Sponsors!
OTPLinks.com

Decoding GLP-1 Book
Decoding GLP-1: A Guide for Friends and Family of Those On The Pen
Buy Here: https://amzn.to/3Dc66d4

MY WORK RELIES ON YOUR GENEROSITY, WAYS TO SUPPORT:
Venmo: OnThePen
Ca$h App: ManOnMounjaro

BECOME A MEMBER:
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Thank you for tuning in! If you found this content valuable, make sure to like, share, and subscribe to my youtube channel for more updates on GLP-1, obesity, type 2 diabetes, and the latest news on Mounjaro, Zepbound, Wegovy, and Ozempic. Stay informed and entertained with my unique blend of breaking news, humor, and my personal journey. For in-depth articles and resources, visit onthepen.com.

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Ozempic, Trulicity and Victoza are decreasing dementia by 45%, so what is going on with Medicare coverage for obesity medicine?

The Knapp family was featured in a health.com video!
Watch it Here: https://www.health.com/beyond-obesity-glp1-8685599

WAYS TO SUPPORT MY WORK ⬇️

💊 OVER THE COUNTER ORAL PEPTIDE SUPPLIMENTS:
BPC-157 // Can’t Weight // TB4-FRAG // KPV
Sign up here and use code “OTP10” to save 10%
https://integrativepeptides.com/OTP

WHY I TRUST INTEGRATIVE PEPTIDES:
🇺🇸 Made in the USA
📋 CGMP Compliant (FDA oversight of their products)
🧑‍⚕️Trusted and Sold By Doctors and Clinics all over the USA

📕 GET MY BOOK!
Decoding GLP-1: A Guide for Friends and Family of Those On The Pen By Dave Knapp
https://amzn.to/4gAXrz4

SOCIALS:
📸 : https://www.instagram.com/onthepen.official/profilecard/?igsh=dTRhY3JkYWo1bTIx
🇨🇳: https://www.tiktok.com/@manonthemounjaro?_t=ZP-8sr5PrUuPQl&_r=1
👾: https://discord.gg/ZHeUh7WV
📺: https://youtube.com/@ManOnTheMounjaro?feature=shared
❌: https://x.com/manonthepen?s=21
💻: https://www.onthepen.com

🤝 Visit Our Sponsors!
OTPLinks.com

Decoding GLP-1 Book
Decoding GLP-1: A Guide for Friends and Family of Those On The Pen
Buy Here: https://amzn.to/3Dc66d4

MY WORK RELIES ON YOUR GENEROSITY, WAYS TO SUPPORT:
Venmo: OnThePen
Ca$h App: ManOnMounjaro

BECOME A MEMBER:
https://www.youtube.com/channel/UCDocQ-4IhVS3ihy_dW7nSKw/join

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WATCH MORE!
📺 We're Live M/W/F at 11 central: onthepen.tv


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Thank you for tuning in! If you found this content valuable, make sure to like, share, and subscribe to my youtube channel for more updates on GLP-1, obesity, type 2 diabetes, and the latest news on Mounjaro, Zepbound, Wegovy, and Ozempic. Stay informed and entertained with my unique blend of breaking news, humor, and my personal journey. For in-depth articles and resources, visit onthepen.com.

Send a text

💊 Orally Bioavailable Peptides:
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Why I trust Integrative Peptides:
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🧑‍⚕️Trusted and Sold By Doctors and Clinics all over the USA

SOCIALS:
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👾: https://discord.gg/ZHeUh7WV
📺: https://youtube.com/@ManOnTheMounjaro?feature=shared
❌: https://x.com/manonthepen?s=21
💻: https://www.onthepen.com

🤝 Visit Our Sponsors!
OTPLinks.com

Decoding GLP-1 Book
Decoding GLP-1: A Guide for Friends and Family of Those On The Pen
Buy Here: https://amzn.to/3Dc66d4

MY WORK RELIES ON YOUR GENEROSITY, WAYS TO SUPPORT:
Venmo: OnThePen
Ca$h App: ManOnMounjaro

BECOME A MEMBER:
https://www.youtube.com/channel/UCDocQ-4IhVS3ihy_dW7nSKw/join

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WATCH MORE!
📺 We're Live M/W/F at 11 central: onthepen.tv


📲 Contact Me: dave@onthepen.com

Thank you for tuning in! If you found this content valuable, make sure to like, share, and subscribe to my youtube channel for more updates on GLP-1, obesity, type 2 diabetes, and the latest news on Mounjaro, Zepbound, Wegovy, and Ozempic. Stay informed and entertained with my unique blend of breaking news, humor, and my personal journey. For in-depth articles and resources, visit onthepen.com.

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Dave sits down with a favorite OTP guest, Dr. Spencer Nadolsky of the Docs Who Lift Podcast to discuss a recent study that asked, “Does Sucralose Increase Hunger?” Dr. Spencer gives his take.

Decoding GLP-1: A Guide for Friends and Family of Those On The Pen By Dave Knapp
📱 Amazon Kindle Reader: https://amzn.to/4gAXrz4
📖Paperback: https://amzn.to/4gAXrz4

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USE CODE "OTP10" to save 10%.

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👾: https://discord.gg/ZHeUh7WV
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❌: https://x.com/manonthepen?s=21
💻: https://www.onthepen.com

🤝 Visit Our Sponsors!
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Decoding GLP-1 Book
Decoding GLP-1: A Guide for Friends and Family of Those On The Pen
Buy Here: https://amzn.to/3Dc66d4

MY WORK RELIES ON YOUR GENEROSITY, WAYS TO SUPPORT:
Venmo: OnThePen
Ca$h App: ManOnMounjaro

BECOME A MEMBER:
https://www.youtube.com/channel/UCDocQ-4IhVS3ihy_dW7nSKw/join

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WATCH MORE!
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Thank you for tuning in! If you found this content valuable, make sure to like, share, and subscribe to my youtube channel for more updates on GLP-1, obesity, type 2 diabetes, and the latest news on Mounjaro, Zepbound, Wegovy, and Ozempic. Stay informed and entertained with my unique blend of breaking news, humor, and my personal journey. For in-depth articles and resources, visit onthepen.com.

Send a text

Decoding GLP-1: A Guide for Friends and Family of Those On The Pen By Dave Knapp
📱 Amazon Kindle Reader: https://amzn.to/4gAXrz4
📖Paperback: https://amzn.to/4gAXrz4

💊 Peptide Supplement I Use: https://integrativepeptides.com/AFFILITATES/OTP
USE CODE "OTP10" to save 10%.

SOCIALS:
📸 : https://www.instagram.com/onthepen.official/profilecard/?igsh=dTRhY3JkYWo1bTIx
🇨🇳: https://www.tiktok.com/@manonthemounjaro?_t=ZP-8sr5PrUuPQl&_r=1
👾: https://discord.gg/ZHeUh7WV
📺: https://youtube.com/@ManOnTheMounjaro?feature=shared
❌: https://x.com/manonthepen?s=21
💻: https://www.onthepen.com

#zepbound #mounjaro #onthepen

🤝 Visit Our Sponsors!
OTPLinks.com

Decoding GLP-1 Book
Decoding GLP-1: A Guide for Friends and Family of Those On The Pen
Buy Here: https://amzn.to/3Dc66d4

MY WORK RELIES ON YOUR GENEROSITY, WAYS TO SUPPORT:
Venmo: OnThePen
Ca$h App: ManOnMounjaro

BECOME A MEMBER:
https://www.youtube.com/channel/UCDocQ-4IhVS3ihy_dW7nSKw/join

👉 My Amazon Affiliate Store:
https://www.amazon.com/shop/manonthemounjaroonthepen

WATCH MORE!
📺 We're Live M/W/F at 11 central: onthepen.tv


📲 Contact Me: dave@onthepen.com

Thank you for tuning in! If you found this content valuable, make sure to like, share, and subscribe to my youtube channel for more updates on GLP-1, obesity, type 2 diabetes, and the latest news on Mounjaro, Zepbound, Wegovy, and Ozempic. Stay informed and entertained with my unique blend of breaking news, humor, and my personal journey. For in-depth articles and resources, visit onthepen.com.

Send a text

Decoding GLP-1: A Guide for Friends and Family of Those On The Pen By Dave Knapp
📱 Amazon Kindle Reader: https://amzn.to/4gAXrz4
📖Paperback: https://amzn.to/4gAXrz4

💊 Peptide Supplement I Use: https://integrativepeptides.com/AFFILITATES/OTP
USE CODE "OTP10" to save 10%.

SOCIALS:
📸 : https://www.instagram.com/onthepen.official/profilecard/?igsh=dTRhY3JkYWo1bTIx
🇨🇳: https://www.tiktok.com/@manonthemounjaro?_t=ZP-8sr5PrUuPQl&_r=1
👾: https://discord.gg/ZHeUh7WV
📺: https://youtube.com/@ManOnTheMounjaro?feature=shared
❌: https://x.com/manonthepen?s=21
💻: https://www.onthepen.com

#zepbound #mounjaro #onthepen

🤝 Visit Our Sponsors!
OTPLinks.com

Decoding GLP-1 Book
Decoding GLP-1: A Guide for Friends and Family of Those On The Pen
Buy Here: https://amzn.to/3Dc66d4

MY WORK RELIES ON YOUR GENEROSITY, WAYS TO SUPPORT:
Venmo: OnThePen
Ca$h App: ManOnMounjaro

BECOME A MEMBER:
https://www.youtube.com/channel/UCDocQ-4IhVS3ihy_dW7nSKw/join

👉 My Amazon Affiliate Store:
https://www.amazon.com/shop/manonthemounjaroonthepen

WATCH MORE!
📺 We're Live M/W/F at 11 central: onthepen.tv


📲 Contact Me: dave@onthepen.com

Thank you for tuning in! If you found this content valuable, make sure to like, share, and subscribe to my youtube channel for more updates on GLP-1, obesity, type 2 diabetes, and the latest news on Mounjaro, Zepbound, Wegovy, and Ozempic. Stay informed and entertained with my unique blend of breaking news, humor, and my personal journey. For in-depth articles and resources, visit onthepen.com.

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In this rare and exclusive interview, the chairman of the Outsourcing Facilities Association sits down with On The Pen to discuss the current landscape of compound tirzepatide.

Www.503bs.org

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Decoding GLP-1 Book
Decoding GLP-1: A Guide for Friends and Family of Those On The Pen
Buy Here: https://amzn.to/3Dc66d4

MY WORK RELIES ON YOUR GENEROSITY, WAYS TO SUPPORT:
Venmo: OnThePen
Ca$h App: ManOnMounjaro

BECOME A MEMBER:
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Published 2025-03-25

Novo’s Retatrutide Competitor

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​⁠’s course, use code “OTP20” to save 20%!
https://www.drtyna.com/offers/VstUywXc/checkout

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Dave discusses the latest in the compound tirzepatide legal battles, cagrisema delivers more big let downs, and some exciting news about VK2735 aka Vikingtide
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Dr. Catherine Harmon Toomer is a board certified Family Medicine physician, certified hypnotherapist & NLP practitioner, founder of TOTAL Weight Care Institute™️ and Your Light Wellness & Weight Care Group. She provides comprehensive and compassionate alternative to the shame-to-change model & yo-yo progress too often experienced in wellness and weight health spaces.

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The latest in compounded semaglutide and tirzepatide, as well as the meaning behind World Obesity Day

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GLP-1 community builder Mike Donnelly-Boylen joins Dave to discuss his health mission and experience losing 100 pounds with Mounjaro!

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Lilly releases higher dose Zepbound vials, reduces price for patients paying out of pocket. Meanwhile, the tirzepatide lawsuit heats up, with a potential ruing on preliminary injunction. The OFA strikes up a new battle with the FDA, suing them now over the end of the semaglutide shortage.
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OTP legal expert Lee Thomas joins to discuss the latest in the compound Tirzepatide lawsuit. Dr Simin Lee joins Dave to discuss obesity, GLP-1 medications and heart health!

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📚 Book Relaunch: The book “Decoding GLP-1” is back on Amazon, now priced at $10, thanks to community advocacy.
⏳ Compounding Update: The FDA has delayed enforcement on 503A pharmacies until a court ruling expected by February 25.
🔬 Fat Cell Research: New findings suggest fat cells may help tailor obesity treatments based on individual profiles.
💊 PBM Concerns: Advocacy for Pharmacy Benefit Manager reform highlights their impact on drug prices and patient access.
📈 Investor Insights: Amalin shows promise in obesity treatment, with new research indicating its effects on appetite and food choices.
🏥 Upcoming Medications: Kagema is anticipated to hit the market in early 2026, alongside new developments from various companies.
🎉 Community Engagement: The podcast encourages listeners to subscribe and support ongoing efforts in obesity medicine discussions

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On the 101st episode of On The Pen Live, Dave discusses this week's news in GLP-1, we get weight loss maintenance tips from Korrie, and a Reddit recap from @FitFlavorFun ! For the interview portion, Dave welcomes Charles aka @RoundMoundofZepbound to discuss his health story as well as dealing with a cancer diagnosis after Zepbound weight loss.

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Published 2025-02-11

Lilly Announces Next Gen Tirzepatide

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Breaking Compound Tirzepatide News
Lilly announces next generation of GLP-1 / GIP med
Trump advocates for cheaper "Fat Shot"
HIMS faces industry scrutiny

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In the 100th episode of On The Pen Live, BJ Davis shares his inspiring 158 lb weight loss journey using Mounjaro, revealing how GLP-1 medications, exercise, and lifestyle changes transformed his life. With insights into the power of community support and expert advice, this milestone episode is a must-listen for anyone interested in sustainable weight loss and the role of GLP-1s in long-term health success!

First Episode with BJ: https://www.youtube.com/live/ZrTZGwbNW98

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Dave Knapp breaks down what the Q4 Eli Lilly earnings call means for patients living with obesity.

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From high dose semaglutide to cagrisema launch dates, Dave Knapp discusses how the latest Novo Nordisk earnings call impacts patients.

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Dave covers this week's news in GLP-1 and anti-obesity medicine news.

#RETATRUTIDE #ENOBARSARM #zepbound

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Jamie has lost 463 pounds combining #Ozempic then #Mounjaro #Tirzepatide and Weight Loss Surgery.

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  • Lilly to offer higher doses of #Zepbound for less money?
  • New obesity definition
  • High dose #Wegovy trial data
  • APC releases FDA info on enforcement of compounded #tirzepatide

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Published 2025-01-17

TikTok GLP-1 Refugees Episode

64 min
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With the impending TikTok ban, Dave has invited TikTok creators who are migrating to YouTube to share a little bit about their GLP-1 content that they will be offering on their new channels!

#zepbound #mounjaro #tirzeptatide

Links To New Creators:
@chanelzway
@Mike.on.a.Mission2
@mydarlingdaisyhello
@jacklemay03
@the_designgirl
@breena_727
@Shayla_Kay
@TheGLP1HolisticQueen
@KeriLeighParker-Mast
@lv_doestirzeppy
@lisaborders70
@glp1realtalk
@Wellness.Scrummaster
@GLP1Collective
@BrianRantsAboutStuff

https://www.obesityaction.org/action-center/access-issues/CMSPublicCommentJanuary2025

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https://www.onthepen.com/post/compounders-win-small-battle-in-war-over-zepbound-and-mounjaro-shortages

https://www.onthepen.com/post/compounders-win-small-battle-in-war-over-zepbound-and-mounjaro-shortages

https://www.obesityaction.org/action-center/access-issues/CMSPublicCommentJanuary2025

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Our good friend OTP legal correspondant @LeeFitsIn joins us to give us his expert take on the current lawsuit over the #Zepbound and #Mounjaro shortage lawsuit.

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Dave brings you up to speed on the latest for all GLP-1 compounded medications.
https://www.onthepen.com/post/zepound-and-mounjaro-shortage-judge-makes-shocking-move

https://forum.policiesforpeople.com/t/compound-tirzepatide-and-semaglutide-transparency-in-fda-drug-shortage-process-503b-protection/7821

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Published 2024-12-30

More Generic GLP-1 Options Hit The Market!

41 min
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In this special Christmas Eve Eve episode of On The Pen: The Weekly Dose, host Dave Knapp dives into groundbreaking updates in GLP-1 medication news, including terzepatide's FDA recognition for resolving obstructive sleep apnea, which could revolutionize insurance coverage for Zepbound. The podcast covers expanded access to generic liraglutide, highlighting its affordability and potential impact on maintenance therapy for obesity and diabetes. Dave also discusses Eli Lilly’s victory against unauthorized terzepatide imports, emphasizing patient safety while critiquing the company's approach to compounded medications. Updates on Novo Nordisk’s Cagrisema trials reveal investor disappointment despite significant weight-loss results, sparking comparisons with Terzepatide and emerging competitors like Retatrutide. The episode wraps up with exciting giveaways, a review of Dave’s book Decoding GLP-1, and insights into protein intake's role in preventing hair loss during rapid weight loss. For the latest in GLP-1 treatments, giveaways, and expert insights, this podcast is your ultimate resource.

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Published 2024-12-17

On The Pen: The Weekly Dose 12.17.24

25 min
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In this special episode of the On The Pen Podcast, I sit down with Shantanu Gaur, the visionary CEO and co-founder of Allurion, to dive deep into the science and innovation behind the Allurion Balloon—a non-surgical, FDA-approved weight loss solution that’s transforming the way we approach obesity treatment.

We discuss the technology behind this swallowable gastric balloon, its role in reducing food intake and promoting sustainable weight loss, and how Allurion combines cutting-edge tools like a digital companion app, connected scale, and health tracker to support long-term success. Shantanu also shares insights into the company’s mission to make weight loss accessible and the future of non-invasive obesity treatments.

Whether you're considering weight loss options or curious about the next big leap in obesity care, this episode is packed with expert insights and actionable information. Tune in to learn more about how the Allurion Balloon is helping people achieve transformative results without surgery, and why Shantanu Gaur believes this could be a game-changer in the fight against obesity.

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Decoding GLP-1: A Guide for Friends and Family of Those On The Pen
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https://www.onthepen.com/post/novo-nordisk-catalent-deal-approved

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Published 2024-12-11

CagriSema Delay? Novo Catalent Update

21 min
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https://diabetes.org/newsroom/press-releases/american-diabetes-association-announces-statement-compounded-incretin

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CEO and Co-Founder of Fractyl Health ($GUTS) Dr. Harith Rajagopalan joins On The Pen to discuss their #Revita and #Rejuva programs for type 2 diabetes and obestity

https://www.fractyl.com/

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Dr Michael Albert and Dave Knapp discuss the current events in GLP-1 medications as well as the horizon of future anti obesity medicine.

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Published 2024-11-26

Medicare to Cover Zepbound and Wegovy?

22 min
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https://www.onthepen.com/post/medicare-medicaide-to-cover-zepbound-here-s-why-it-s-not-as-simple-as-it-sounds

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Ali G. from @FitFlavorFun joins Dave to talk all things GLP-1!

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Published 2024-11-19

On The Pen: The Weekly Dose 11.19.24

22 min
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https://www.nature.com/articles/d41586-024-03614-9

https://www.wsj.com/health/pharma/weight-loss-drugs-employer-healthcare-coverage-12817e4f

https://www.reuters.com/business/healthcare-pharmaceuticals/medicaid-fuels-us-coverage-novo-lilly-weight-loss-drugs-2024-11-18/

https://www.biospace.com/drug-delivery/novos-wegovy-launched-in-china-at-a-fraction-of-us-price

https://www.wsj.com/health/pharma/eli-illy-novo-ozempic-zepbound-copycats-e6171fdd

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Dave reviews the CNN special with Dr Sanjay Gupta on GLP-1 medications.

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Dr Spencer Nadolski of the “Docs Who Life” podcast joins Dave to recap obesity week, and to deep dive into Dave’s ongoing struggle with obesity and type 2 diabetes.

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In this episode of On The Pen: The Weekly Dose, host Dave Knapp dives into the latest updates in obesity medicine, with insightful takes on current treatment breakthroughs, new medication approvals, and tips on navigating healthcare options. This week’s deep dive also touches on emerging trends in GLP-1 therapy and how recent shifts may impact accessibility for patients. Whether you’re just starting your journey or a long-time follower of GLP-1 news, this episode brings you the essentials. ​ 

Maritide Bone Density Loss:
https://www.statnews.com/2024/11/12/amgen-maritide-obesity-drug-candidate-data/

Catalent Novo Merger:
https://www.biospace.com/deals/lilly-vs-novo-the-he-said-she-said-row-about-catalents-glp-1-work

Novo War On Compounds:
https://www.onthepen.com/post/shocking-truth-about-semaglutide-what-novo-nordisk-doesn-t-want-you-to-know

Drug Shortage Policy Reform Request (VOTE!):
https://forum.policiesforpeople.com/t/compound-tirzepatide-and-semaglutide-transparency-in-fda-drug-shortage-process-503b-protection/7821

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Semaglutide News: https://www.onthepen.com/post/select-trial-update-semaglutide-s-cardiovascular-benefits-and-psychiatric-safety-profile-highlighte

Viking Therapeutics News:
https://www.onthepen.com/post/vk2735-vikingtide

AstraZeneca News: 
https://www.onthepen.com/post/astrazeneca-s-azd5004-a-power-move-in-obesity-medicine

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Dave brings his analysis of the Q3 Eli Lilly earnings call, and how it relates to the future of access to obesity medicine. Also there is an important clarification on the Zepbound savings card that you should not miss.

#Zepbound #Mounjaro #Tirzepatide


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Lilly Releases 2025 Zepobound Savings Card Details:
https://www.onthepen.com/post/breaking-zepbound-savings-card-2025-released-what-you-need-to-know

Novo Nordisk Petitions FDA to Add Semaglutide to DDC list: https://www.onthepen.com/post/compound-semaglutide

Eli Lilly Petiioned FDA in Augus to add Tirzepatide to DDC list:
https://www.onthepen.com/post/compound-tirzepatide



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An article on the news broken by Mr Brunner on compound Tirzepatide: https://www.onthepen.com/post/compound-tirzepatide

a4pc.org
compounding.com

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Lilly Lawsuits: https://www.onthepen.com/post/eli-lilly-zepbound-tirzepatide-lawsuits

Catalent Merger: https://www.businesswire.com/news/home/20241020996199/en/Catalent-Issues-Open-Letter-to-Customers-Regarding-Pending-Acquisition-by-Novo-Holdings

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OTP legal correspondent Lee (@LeeFitsIn) joins Dave to discuss where we stand in the legal battle over compounded versions of Zepbound and Mounjaro. (Apologies for audio, the interview was a TikTok live recording).
 
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Zepbound Compound News:
https://www.onthepen.com/zepbound-news

New type two diabetes treatment:
https://www.upi.com/Health_News/2024/10/14/ozempic-intestinal-therapy-eliminate-insulin-Type-2-diabetics/6911728911126/

Using GLP-1  to improve workforce participation:
https://www.independent.co.uk/news/health/weight-loss-drugs-nhs-tirzepatide-mounjaro-b2629171.html

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Published 2024-10-11

Heartbreaking Zepbound Story | OTP Eps 85

86 min
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OTP community member Megan a.k.a. Spoonie Megumi shares her heartbreaking journey to Zepbound.

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Semaglutide Patent: https://www.fiercepharma.com/pharma/novos-patent-litigation-settlement-mylan-could-pave-way-cheaper-ozempic-generics

Outsourcing Facilities Association Lawsuit: https://www.reuters.com/legal/compounding-group-sues-fda-removing-lillys-weight-loss-drug-shortage-list-2024-10-07/

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Dr. Daniel Rosen talks candidly about his approach to slow responders to GLP medications in his bariatric clinic.

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PORT WORKER STRIKE: https://www.cnbc.com/2024/10/01/port-strike-blockbuster-weight-loss-drug-supply-trade-shutdown.html

ZEPBOUND FOR NON-OBESE: https://www.ft.com/content/b2da2ca6-822e-4d42-bee4-e500522531e7

WEIGHT WATCHERS CEO OUT: https://www.bloomberg.com/news/articles/2024-09-27/weightwatchers-replaces-ceo-sima-sistani-after-stock-plummets?leadSource=uverify%20wall

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Amy Kane (@AmyInHalf) joins to talk about her rise to GLP stardom, and Dave discusses all the relevant news of the week!

Aired live at 9pm central, Thursday 9/26/24.

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GLP-1 Clapback Queen Amy Kane | OTP Eps 83
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Published 2024-09-24

On The Pen: The Weekly Dose 9.24.24

24 min
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Metsera MET-097: https://www.fiercebiotech.com/biotech/metseras-long-acting-glp-1-shot-linked-75-weight-loss-36-days-data-sparse

Biomed Pharma NA-931: https://www.biomedind.com/NA-931.html

Watch the Novo Nordisk Hearings: https://youtube.com/live/bcgIVb3EJsU

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We discuss the Eli Lilly letters that are going out to users of compound Tirzepatide. Mimi from the #Retatrutide trial joins! Plus our new segment maintenance minute with Korrie, where Korrie discusses all things weight maintenance!
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Discord: https://discord.gg/QUEp5DBeNew 
New Facebook Group: https://www.facebook.com/share/g/Ab2ApGdaqRQj1T6c/

Medicare and Ozempic
https://qz.com/ozempic-price-cut-medicare-negotiations-1851650680

BCBS Demanding Payments from Off Label Ozempic Prescribers
https://www.bloomberg.com/news/articles/2024-09-12/off-label-ozempic-prescriptions-spark-1-million-demand-from-insurer

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Published 2024-09-10

On The Pen: The Weekly Dose 9.10.24

23 min
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Zealand News:
https://www.globenewswire.com/news-release/2024/09/09/2943004/0/en/Zealand-Pharma-announces-positive-topline-results-from-13-week-Phase-1b-multiple-ascending-dose-clinical-trial-with-GLP-1-GLP-2-receptor-dual-agonist-dapiglutide.html
Roche News:
https://www.bloomberg.com/news/articles/2024-09-09/roche-falls-as-side-effects-data-for-obesity-drug-raises-concern
Tern News:
https://www.fiercebiotech.com/biotech/terns-oral-glp-1-shows-5-weight-loss-1-month-highest-dose

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Dr. Spencer Nadolsky has announced his departure from Weight Watchers and joins Dave live for a chat about Zepbound GLP1 meds and Obesity medicine.

#WW #WeightWatchers #DrSpencer

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SHOW NOTES

WEGOVY REDUCES COVID DEATHS
https://www.wjbf.com/news/popular-weight-loss-drug-reduced-risk-of-covid-deaths-in-new-study/

WEGOVY REDUCES HEART DISEASE RISK BY 20%
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(24)01498-3/fulltext

OZEMPIC SHORTAGE TO LAST THROUGH 2024
https://www.biospace.com/business/novos-ozempic-to-remain-in-shortage-into-q4-as-supply-woes-continue

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Christopher and Laraine Durham of @TheDownsized join Dave to discuss the Zepbound vials arrival and the changes to the Zepbound savings card!

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Published 2024-08-27

Massive Zepbound Vials News 8.27.24

16 min
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RO TOOLS TO HELP YOU:
Ro Body: ro.co/otp
#ReportTheShortage - ro.co/supply-tracker
#OptInForObesity - See if you're covered ro.co/checker

Madison Muller Article on Zepbound Vial Pricing:
https://www.bloomberg.com/news/articles/2024-08-27/eli-lilly-is-now-selling-zepbound-weight-loss-drug-at-50-discount?srnd=undefined

Search Zepbound Pricing:
https://www.goodrx.com/zepbound/what-is

Empoloyer Form Letter to Add Obesity Coverage:
https://www.onthepen.com/post/optinforobesity-how-petitioning-your-employer-can-break-the-barriers-to-obesity-treatment

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Published 2024-08-19

On The Pen: The Weekly Dose 8.20.24

20 min
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VOTE FOR THE WEEKLY DOSE PODCAST!
CHECK OUT OUR SPONSOR: RO.CO/OTP

Semaglutide in Parkinsons and Opiod Abuse
https://www.wired.com/story/the-benefits-of-ozempic-are-multiplying/?

How Roche Passed on Orforglipron
https://www.swissinfo.ch/eng/multinational-companies/how-roche-passed-on-a-potential-14bn-a-year-weight-loss-pill/86877239?fbclid=IwZXh0bgNhZW0CMTEAAR1doDlsWIFXuUJYA9Kz75D9VvzZycgqm2kVbVPuWWFgOP0tvOVNvIWluVY_aem_GDMhnl8sQEVePWYy0XdheQ

Roche's Obesity Pipeline
https://www.onthepen.com/post/more-threats-to-lilly-s-tirzepatide-printing-press

Novo Announced Additional API Site
https://www.fiercepharma.com/pharma/novo-create-50-jobs-new-220m-raw-ingredients-plant-will-support-ozempic-and-wegovy

Patients Splitting Pens
https://www.theatlantic.com/health/archive/2024/08/ozempic-hackers/679464/


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Published 2024-08-13

On The Pen: The Weekly Dose 8.13.24

20 min
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#ReleaseTheVials
https://www.onthepen.com/post/eli-lilly-to-releasethevials-of-zepbound
Eli Lilly has released single-dose vials for ZepBound to stabilize higher dose supplies and removed all Mounjaro and ZepBound doses from the FDA shortage list, though tirzepatide remains in shortage. Novo Nordisk is seeking FDA approval for Icosema, a combination of insulin and semaglutide, with a favorable safety profile.

Lilly Sends Tirzepatide Compound Cease and Desist Letters
https://www.onthepen.com/post/it-begins-eli-lilly-fires-off-round-of-cease-and-desist-letters-to-tirzepatide-peddlers

Eli Lilly is taking legal action against GLP-1 compounders, particularly targeting ZepBound. Cease and desist letters have been issued to smaller prescribers and med spas, potentially pressuring the FDA on tirzepatide’s shortage status.

#ReportTheShortage
Ro.co/supply-tracker

Patients are encouraged to report ZepBound or Mounjaro shortages to the FDA. Ro has introduced a supply tracker tool to notify patients of nearby availability and launched RoBody, a program connecting patients with doctors to manage obesity and achieve significant weight loss.

Insurance Checker Toll
Ro.co/checker

Ro's new GLP-1 Insurance Coverage Checker allows users to check insurance coverage for obesity medications and is integrated with the supply tracker. Despite financial struggles, 23andMe is launching a GLP-1 telehealth service. The ‘Opt-in for Obesity’ campaign encourages employees to request obesity coverage from their employers.

On The Pen Live

Z Reitano from Ro will discuss the GLP-1 Insurance Coverage Tool on the upcoming On The Pen Live session, airing on YouTube this Thursday at 9 p.m. Central.

#OptInForObesity
https://www.onthepen.com/post/optinforobesity-how-petitioning-your-employer-can-break-the-barr

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Published 2024-08-06

On The Pen: The Weekly Dose 8.6.24

19 min
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Fortune interview:

Tirzepatide shortages (viral tiktok video with 199,000+ views):

Tirzepatide heart trial (viral tiktok video with 90,000+ views)

semaglutide pre-diabetes trial:

Weight Watchers:


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Published 2024-07-30

On The Pen: The Weekly Dose 7.30.24

21 min
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Book Email Alerts: https://www.onthepen.com/glp1-book
Altimmune

Novo Nordisk Expansion:

Novo Nordisk Fire:

Novo Nordisk EU Wegovy:

Roche:

Weight Watchers Resignation:

FDA and compounding:

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Published 2024-07-22

On The Pen: The Weekly Dose 7.23.24

16 min
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On The GLP-1 Pen Book Alerts:
https://onthepen.com/emails

Gan & Lee (China)
https://www.prnewswire.com/news-releases/gan--lee-pharmaceuticals-bi-weekly-twice-a-month-glp-1-receptor-agonist-gzr18-injection-achieved-17-29-weight-loss-at-30-weeks-in-a-phase-iib-clinical-trial-302202575.html

Mazdutide (China):
https://www.fiercebiotech.com/biotech/innovent-bags-another-phase-3-win-next-gen-lilly-glp-1-drug

China:
https://www.reuters.com/business/healthcare-pharmaceuticals/eli-lillys-weight-loss-drug-tirzepatide-gets-approval-china-2024-07-19/

Retatrutide (tiktok video):
https://www.nature.com/articles/s41421-024-00700-0

GLP-1 Temperature Monitor:
https://www.varcode.com

Eli Lilly:
https://www.bioprocessonline.com/doc/how-eli-lilly-s-making-peptides-faster-and-more-reliably-0001

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Published 2024-07-15

On The Pen: The Weekly Dose 7.16.24

21 min
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PBM reform in Illinois (tiktok video)

FTC on PBM

FDA and social media (tiktok video)

Patient weight-loss expectations

Wegovy commercial:

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Send a text

Dave chats with world renowned obesity expert who consults for the likes of Novo Nordisk!

Beverly Tchang, MD is a triple board-certified physician  with a focus on obesity medicine. Since 2018, she has been treating patients and training professionals in endocrinology and obesity. Her nationally recognized expertise has led her to extend her knowledge and experience as an advisor to  companies, entrepreneurs, and investors who  want to learn about modern weight management. 
BeverlyTchangMD.com
X: @bevTchangMD

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Published 2024-07-08

On The Pen: The Weekly Dose 7.9.24

15 min
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Ozempic reduces cancer risk:

Semaglutide correlated with blindness (tiktok video):


15-years as type-2 diabetic results in a 78% chance of have some degree of retinal eye damage

Update to Mounjaro/ZepBound FDA shortage on 7/2/2024 (tiktok video)
#releasethevials

Mounjaro KwikPen coming to Australia

  • News provided by Mimi from Australia (Mimi featured in Live #61 -- part of Retatrutide trials

GIP scientific study:

semaglutide vs. tirzepatide

Keto diet:

High-price of GLP-1 medications:

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Published 2024-07-02

On The Pen: The Weekly Dose 7.2.24

20 min
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Get OTP Emails: https://www.onthepen.com/emails

Eli Lilly

Him & Hers:

Price for generic liraglutide/Victoza (multiple tiktok videos):

TROA

BI 3034701 (tiktok video):

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Published 2024-06-25

On The Pen: The Weekly Dose 6.25.24

18 min
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Novo Nordisk expansion in the US:
https://www.novonordisk.com/news-and-media/news-and-ir-materials/news-details.html?id=168528

Generic liraglutide
https://www.onthepen.com/post/teva-launches-first-ever-generic-glp-1-a-game-changer-for-diabetes-and-weight-management

New Wegovy Coupon:
https://www.wegovy.com/coverage-and-savings/save-on-wegovy.html

New Mounjaro Card (tiktok video)
https://mounjaro.lilly.com/savings-resources

Tirzepatide (tiktok video):
https://www.reuters.com/business/healthcare-pharmaceuticals/weight-loss-drug-zepbound-resolves-sleep-apnea-up-52-patients-lilly-says-2024-06-21/

Petrelintide
https://www.onthepen.com/post/introducing-petrelintide-discover-the-promise-of-amalyn-agonist-medications-for-weight-loss

Gut bacteria:

DACRA:
https://ir.vikingtherapeutics.com/2024-06-24-Viking-Therapeutics-Presents-Preclinical-Data-on-Novel-Dual-Amylin-and-Calcitonin-Receptor-Agonists-at-84th-Scientific-Sessions-of-the-American-Diabetes-Association

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Published 2024-06-18

On The Pen: The Weekly Dose 6.18.24

17 min
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PBM Reform Form Letter: 

  • Link to the Letter: https://www.onthepen.com/post/pbm-reform-form-letter-for-elected-representatives

Express scripts (tiktok video on PBM reform):

Michigan (tiktok video)

Accessibility

Vivani (tiktok)

Diet on GLP-1:

Online GLP-1s:


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Published 2024-06-12

Zepbound And Liver Disease

9 min
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Eli Lilly's phase 2 SYNERGY-NASH study shows tirzepatide effectively resolves MASH and improves fibrosis, offering hope for millions. Read more here: https://www.onthepen.com/post/tirzepatide-shows-promise-in-treating-mash-key-findings-from-the-synergy-nash-study

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Published 2024-06-11

On The Pen: The Weekly Dose 6.11.24

18 min
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Ro.co/supply-tracker

FDA shortage update (tiktok video):
Link:https://www.accessdata.fda.gov/scripts/drugshortages/dsp_ActiveIngredientDetails.cfm?AI=Tirzepatide%20Injection&st=c

EASL (European Association for the Study of the Liver) 2024 in Milan Italy
Link: https://investor.lilly.com/news-releases/news-release-details/lillys-tirzepatide-was-superior-placebo-mash-resolution-and-more
Link: https://www.biospace.com/article/mash-clash-between-lilly-and-boehringer-zealand-takes-center-stage-at-easl24/

Walgreen:
Link: https://www.benefitspro.com/2024/06/03/walgreens-will-conduct-clinical-trials-for-boehringer-ingelheims-new-obesity-drug/?slreturn=20240610103336

Kroger (tiktok video):
Link: https://www.aol.com/news/kroger-health-revamps-weight-management-132122808.html

Eli Lilly Clinical trial:
Link: https://clinicaltrials.gov/study/NCT06373146?term=tirzepatide&aggFilters=status:act%20rec&rank=6

Eli Lilly CFO:
Link: https://www.prnewswire.com/news-releases/lilly-announces-departure-of-anat-ashkenazi-chief-financial-officer-302163882.html

China:
Link: https://www.benzinga.com/news/24/06/39197516/chinese-generic-ozempic-wegovy-versions-could-put-novo-nordisk-at-the-risk-of-stiff-competition-in-k



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Published 2024-06-04

On The Pen: The Weekly Dose 6.4.24

17 min
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https://ro.co/weight-loss/supply-tracker
https://www.youtube.com/watch?v=mL_krAas70k

Novo Nordisk Advertising:

  • Novo Nordisk launches new advertising campaign "The Power of Wegovy"
  • This advertisement includes the new indication for reduction of cardiovascular risk
  • For 2023, the #5 advertising spend for a drug was Rybelsus at $191 million.  The #6 advertising spend was Ozempic at $187.4 million (increase of 6% from 2022). More than 40% of the 2023 ad spend for Ozempic  went to online video platforms (i.e. social media like youtube)
  • Link: https://www.youtube.com/watch?v=dhretLXYkZ4

Structure Therapeutics GSBR-1290

  • GSBR-1290 is a small molecule GLP-1 pill
  • In a 12-week phase 2 clinical study, a tablet formulation of GSBR-1290 had a weight-loss of 6.9%. This is comparable to Eli Lilly's phase 2 results for olforglipron
  • At Week 12, 67% of GSBR-1290 treated participants achieved ≥6% weight loss and 33% achieved ≥ 10% weight loss, compared to 0% for placebo
  • Also developing next generation combination GLP-1 candidates together with GIP, amylin, glucagon and apelin oral small molecules
  • Link (Madison Muller): https://www.bloomberg.com/news/articles/2024-06-03/structure-reports-early-oral-weight-loss-drug-data-adding-allure


Elon musk tweet:

  • Elon Musk tweeted: Just make a lot of Ozempic/Mounjaro. It’s not inherently expensive. The health benefits of reducing obesity far exceed the downside of GLP-1 inhibitors. We evolved under starving conditions and now make food that is plentiful and delicious. Whether that food is “processed” does matter, but is not a game changer
  • This tweet has currently been seen 325,500 times

Shanghai Stem Cell Type 2 Diabetes Treatment
https://www.scmp.com/news/china/science/article/3263878/chinese-scientists-report-world-first-they-cure-patients-diabetes-cell-therapy

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Zachariah Reitano is the founder of Ro, a telehealth company that has a vision of giving consumers more power over their health, he joins #OnThePen to talk all things #mounjaro #zepbound #wegovy #ozempic 

Reitano is the founder of Ro, a telehealth company that has a vision of giving consumers more power over their health.

https://ro.co/weight-loss/supply-tracker/

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Thank you for tuning in! If you found this content valuable, make sure to like, share, and subscribe to my youtube channel for more updates on GLP-1, obesity, type 2 diabetes, and the latest news on Mounjaro, Zepbound, Wegovy, and Ozempic. Stay informed and entertained with my unique blend of breaking news, humor, and my personal journey. For in-depth articles and resources, visit onthepen.com.

Published 2024-05-28

On The Pen: The Weekly Dose 5.28.24

18 min
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On The Pen News: https://www.onthepen.com/blog

SHOW NOTES:
Ozempic study in New England Journal of Medicine:
Link: https://www.bloomberg.com/news/articles/2024-05-24/novo-s-ozempic-slashes-risk-of-death-in-kidney-disease-study

Compounding (tiktok video)
Link: https://www.abc.net.au/news/2024-05-22/compound-pharmacies-banned-weight-loss-drugs-replica-ozempic/103861108

Zealand Pharma:
Link: https://www.biospace.com/article/zealand-touts-phase-i-results-for-glp-1-glp-2-candidate-despite-modest-weight-loss-/

Inhaled GLP-1 medications
Link: https://www.biostock.se/en/2024/05/iconovo-initiates-development-of-inhaled-obesity-treatment/

Oral version of tirzepatide (tiktok video):
Link: https://ca.finance.yahoo.com/news/lexaria-awards-contract-third-glp-130500555.html

Mounjaro approved for China (tiktok video):
Link: https://www.bloomberg.com/news/articles/2024-05-21/china-clears-eli-lilly-s-weight-loss-drug-tirzepatide-only-for-diabetes

Eli Lilly announces capacity increase (tiktok video)
Link: https://investor.lilly.com/news-releases/news-release-details/lilly-increases-manufacturing-investment-9-billion-newest

GLP-1 usage by young people:
From 2020 to 2023, the number of U.S. adolescents and young adults using GLP-1 increased 600 percent — from roughly 8,700 peo

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In this week’s episode of On The Pen Live, guest Scott Liberto of PlanetScott.com joins to discuss his experience in the Survodutide clinical trial.

Survodutide is an investigational dual agonist targeting both the glucagon and GLP-1 receptors, developed by Boehringer Ingelheim in collaboration with Zealand Pharma. This novel drug is designed to treat obesity and metabolic dysfunction-associated steatohepatitis (MASH). 

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Published 2024-05-21

On The Pen: The Weekly Dose 5.21.24

24 min
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📰 SEEKING ALPHA ARTICLE: https://seekingalpha.com/news/4092598-tiktok-restrict-weight-loss-drug-promotion

🎙️PODCAST LINK: https://podcasts.apple.com/us/podcast/on-the-pen-the-weekly-dose/id1725737068

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SOCIAL LINKS
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📲 Contact Me: MounjaroMan@gmail.com

👉 Link to other GLP-1 MUST HAVE products I mention: https://www.amazon.com/shop/manonthemounjaroonthepen

📼 PLAYLISTS:
🖊️ ON THE PEN LIVES:
https://www.youtube.com/playlist?list=PLtOcNl0C8quVdrWruYSrJpTZPF7jjXKfM
👀 WATCH MY MOUNJARO JOURNEY IN ORDER:
https://www.youtube.com/watch?v=aplFxNOv77g&list=PLtOcNl0C8quWo7PWY9j_HilhWIRuedyiO
😎 NERDS ONLY: LEARN ABOUT OTHER GLP-1 MEDS:
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🚨📰 ALL THE LATEST MOUNJARO NEWS:
https://www.youtube.com/playlist?list=PLtOcNl0C8quVo0I2YODK-q7cHh4y1r2yB

SHOW LINKS:
Novo Nordisk fire:
Link: https://www.wsj.com/livecoverage/stock-market-today-dow-jones-earnings-05-16-2024/card/fire-at-novo-nordisk-construction-site-gives-investors-a-scare-eSSAtdDDhxYwUw3bGDZI?mod=lctimeline_finance

New CagriSema drug trial
Link: https://clinicaltrials.gov/study/NCT06409130

Wegovy Heart Benefits:
Link: https://www.cnn.com/2024/05/13/health/wegovy-trial-analysis/index.html

CT-488 Phase 1 Results:
Link: https://www.fiercebiotech.com/biotech/roches-27b-carmot-bet-pays-phase-1-weight-loss-success

Nothing contained in this podcast is medical advice. Please consult your liscensed p

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Published 2024-05-14

On The Pen: The Weekly Dose 5.14.24

15 min
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#Zepbound #releasethevials #mounjaro

📲 Contact Me: MounjaroMan@gmail.com
👉 Link to other GLP-1 MUST HAVE products I mention: https://www.amazon.com/shop/manonthemounjaroonthepen

📼 PLAYLISTS:
🖊️ ON THE PEN LIVES:
https://www.youtube.com/playlist?list=PLtOcNl0C8quVdrWruYSrJpTZPF7jjXKfM
👀 WATCH MY MOUNJARO JOURNEY IN ORDER:
https://www.youtube.com/watch?v=aplFxNOv77g&list=PLtOcNl0C8quWo7PWY9j_HilhWIRuedyiO
😎 NERDS ONLY: LEARN ABOUT OTHER GLP-1 MEDS:
https://www.youtube.com/playlist?list=PLtOcNl0C8quW-YZuu_DSpt_NS9fVQbMoW
🚨📰 ALL THE LATEST MOUNJARO NEWS:
https://www.youtube.com/playlist?list=PLtOcNl0C8quVo0I2YODK-q7cHh4y1r2yB

SHOW NOTES:
Update on Bernie Sander's fight against high prices for GLP-1 medicationsLink: https://www.msn.com/en-us/health/other/novo-asks-for-more-time-to-answer-sanders-on-ozempic-s-price/ar-BB1lZ0P2

CFO of Viking Therapeutics sold stock
Link: https://www.investing.conews/company-news/viking-therapeutics-cfo-sells-over-49-million-in-company-stock-93CH-3419573

Novo Nordisk bond sale (Bloomberg article):
Link: https://www.bloomberg.com/news/articles/2024-05-13/ozempic-maker-novo-nordisk-plans-bond-sale-to-fund-expansion?embedded-checkout=tru

Why companies should cover obesity mediation
Link: https://ca.news.yahoo.com/obese-people-more-likely-time-22010

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Roche Pharmaceuticals has acquired Carmot Therapeutics along with three obesity and type 2 diabetes candidates: CT-868 / CT-368 / CT-986

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#Zepbound #Maritide #mounjaro 

📲 Contact Me: MounjaroMan@gmail.com
👉 Link to other GLP-1 MUST HAVE products I mention: https://www.amazon.com/shop/manonthemounjaroonthepen

📼 PLAYLISTS:
🖊️ ON THE PEN LIVES:
https://www.youtube.com/playlist?list=PLtOcNl0C8quVdrWruYSrJpTZPF7jjXKfM
👀 WATCH MY MOUNJARO JOURNEY IN ORDER:
https://www.youtube.com/watch?v=aplFxNOv77g&list=PLtOcNl0C8quWo7PWY9j_HilhWIRuedyiO
😎 NERDS ONLY: LEARN ABOUT OTHER GLP-1 MEDS:
https://www.youtube.com/playlist?list=PLtOcNl0C8quW-YZuu_DSpt_NS9fVQbMoW
🚨📰 ALL THE LATEST MOUNJARO NEWS:
https://www.youtube.com/playlist?list=PLtOcNl0C8quVo0I2YODK-q7cHh4y1r2yB

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Thank you for tuning in! If you found this content valuable, make sure to like, share, and subscribe to my youtube channel for more updates on GLP-1, obesity, type 2 diabetes, and the latest news on Mounjaro, Zepbound, Wegovy, and Ozempic. Stay informed and entertained with my unique blend of breaking news, humor, and my personal journey. For in-depth articles and resources, visit onthepen.com.

Published 2024-05-08

On The Pen: The Weekly Dose 5.7.24

17 min
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MY WORK RELIES ON YOUR GENEROSITY, BECOME A MEMBER HERE: https://www.youtube.com/channel/UCDocQ-4IhVS3ihy_dW7nSKw/join 
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#Zepbound #Maritide #mounjaro 

LINKS 
Life Update Blog: Link: https://www.onthepen.com/post/i-m-tired-we-are-tired 

Wegovy released in Canada: 
Link: https://www.msn.com/en-ca/health/other/weight-loss-drug-wegovy-available-in-canada-starting-may-6/ar-AA1o1lZz 

Madison Muller at Bloomberg (friend of our community) had article "Why Weight-Loss Drugs Wegovy, Zepbound Are in Short Supply" 
Link: https://www.bloomberg.com/news/articles/2024-05-02/why-weight-loss-drugs-wegovy-zepbound-are-facing-shortages?srnd=undefined&embedded-checkout=true 

Interviewed on radio station KXEL 
Link: https://www.youtube.com/watch?v=V0YyMwtMuxs 

Optum RX Irony alert: 
Link: https://www.managedhealthcareexecutive.com/view/glp-1-tiering-agreement-reached-says-optum-rx-president 

FTC is challenging Novo Nordisk's patents on Ozempic 
Link: https://www.ftc.gov/system/files/ftc_gov/pdf/novo-nordisk-ozempic-saxenda-victoza-_4302024.pdf 

FTC requested additional information on Novo Nordisk's acquisition of Catalent: 
Link: https://www.msn.com/en-us/money/markets/us-ftc-seeks-more-information-on-novo-nordisk-parent-catalent-deal/ar-AA1o6gHU

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Thank you for tuning in! If you found this content valuable, make sure to like, share, and subscribe to my youtube channel for more updates on GLP-1, obesity, type 2 diabetes, and the latest news on Mounjaro, Zepbound, Wegovy, and Ozempic. Stay informed and entertained with my unique blend of breaking news, humor, and my personal journey. For in-depth articles and resources, visit onthepen.com.

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Dave Knapp does a deep dive into todays  Eli Lilly earnings call.

https://www.onthepen.com/post/zepbound-vial-watch-eli-lilly-earnings-q1-2024

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Thank you for tuning in! If you found this content valuable, make sure to like, share, and subscribe to my youtube channel for more updates on GLP-1, obesity, type 2 diabetes, and the latest news on Mounjaro, Zepbound, Wegovy, and Ozempic. Stay informed and entertained with my unique blend of breaking news, humor, and my personal journey. For in-depth articles and resources, visit onthepen.com.

Published 2024-04-30

On The Pen: The Weekly Dose 4/30/24

16 min
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1.7 mg of Wegovy is no longer in shortage:
Semaglutide: FDA website updated to show 1.7 mg of Wegovy is no longer in shortage
Link: https://www.accessdata.fda.gov/scripts/drugshortages/dsp_ActiveIngredientDetails.cfm?AI=Semaglutide%20Injection&st=c

GNC introduces special section for GLP-1 users:
GNC will have special section for GLP-1 users that will concentrate on four areas: GI Health, Retaining Lean muscle mass, Bone health, Nutritional support
Link: https://www.gnc.com/learn/newsroom/gnc-semaglutide-support-program.html

Identified upper dose values in tirzepatide high-dose trial
20 mg and 25 mg
Primary Completion in this trial is 12/24/2024 (Merry Christmas) with final completion September 30, 2025 
Link:  https://www.onthepen.com/post/higher-doses-of-zepbound-and-mounjaro-being-tested

US Senator Bernie Sanders investigating the price of Wegovy/Ozempic
Ozempic costs $936 per month, while Wegovy costs $1,350
Ozempic costs $155 in Canada, and cost $59 in Germany. This dramatic difference in cost has led to concerns about the accessibility and affordability of these drugs for American patients.
With the cardiovascular disease indication, millions of additional medicare patients are eligible for taking Wegovy which means billions at the current prices 
Link:  https://www.onthepen.com/post/the-price-of-health-bernie-sanders-investigates-ozempic-and-wegovy
Link: https://www.kff.org/medicare/issue-brief/a-new-use-for-wegovy-opens-the-door-to-medicare-coverage-for-millions-of-people-with-obesity/

Germany is promoting their pharmaceuticals industry:
 tax breaks, and speeding up clinical trials
Eli Lilly is investing 2.3 Billion Euros to build a glp-1 manufacturing plant in Germany:
Link: https://uk.finance.yahoo.com/news/scholz-promises-support-pharma-sector-101833297.html

Lexaria begins phase 1 trial:
Lexaria (stock symbol: LEXX) will test their technology to improve stomach absorption of Rybelsus in phase 1 trial (i.e. wouldn't need large 25/50 mg doses if absorption was better). 
They are also testing under tongue (sublingual) absorption of Rybelsus in another phase 1 trial
Link: https://ir.lexariabioscience.com/news-events/press-releases/detail/246/lexaria-receives-ethics-review-board-approval-to-begin-new

Viking Therapeutics earnings call
Planning to start addition phase 2 trial of injectable VikingTide (VK2735) in Q4 of 2024 that will l

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Published 2024-04-23

On The Pen: The Weekly Dose 4/23/24

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New obesity medicine company launches, Lilly expands manufacturing capacity with acquisition, and TikTok censors my content.

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New Obesity Medicine Company Launches: https://metsera.com/news
Lilly Acquires Nexus Facility: https://finance.yahoo.com/news/lilly-buy-injectable-drug-plant-175000782.html
TikTok Mounjaro Zepbound Censorship: https://www.bloomberg.com/news/articles/2024-04-22/tiktok-ozempic-influencers-say-new-rules-unfairly-target-them

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Published 2024-04-19

Zepbound Vials: The Business Case

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Dave Knapp makes the business case for why Eli Lilly won’t simply release the vials - they have to.

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Yahoo Finanace #ReleaseTheVials Feature VIDEO: https://youtu.be/nQbYa47DF4Q?feature=shared

#mounjaro #zepbound #tirzepatide

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Published 2024-04-15

On The Pen: The Weekly Dose 4/16/24

13 min
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This week Dave Knapp covers GLP-1 censorship on TikTok,  the rise of bootleg medication scrutiny, and just how big the GLP-1 market may get in 2024.

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Bloomberg #ReleaseTheVials Feature:
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Yahoo Finanace #ReleaseTheVials Feature VIDEO: https://youtu.be/nQbYa47DF4Q?feature=shared

#mounjaro #zepbound #tirzepatide

Bootleg Meds:
https://www.reuters.com/business/healthcare-pharmaceuticals/more-than-250-websites-selling-fake-weight-loss-drugs-reported-by-anti-2024-04-15/

 Drug Shortage Reporting: https://www.wsj.com/health/healthcare/drug-medication-shortages-us-olympic-amoxicillin-107fa9d8

GLP-1 Sales:
https://www.fiercepharma.com/marketing/glp-1s-track-take-drug-sales-crown-pd-1-inhibitors-2024-analyst

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Published 2024-04-13

Sourcing Compound Tirzepatide

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503a vs 503b pharmacies. What is the difference, and why you should care when it comes to compound tirzepatide and semaglutide.

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https://www.bloomberg.com/news/articles/2024-04-02/zepbound-shortage-patients-push-eli-lilly-to-release-more-obesity-drug-supply

Yahoo Finanace #ReleaseTheVials Feature VIDEO: https://youtu.be/nQbYa47DF4Q?feature=shared

#mounjaro #zepbound #tirzepatide

Thank you for tuning in! If you found this content valuable, make sure to like, share, and subscribe to my youtube channel for more updates on GLP-1, obesity, type 2 diabetes, and the latest news on Mounjaro, Zepbound, Wegovy, and Ozempic. Stay informed and entertained with my unique blend of breaking news, humor, and my personal journey. For in-depth articles and resources, visit my website at onthepen.com. You can also connect with me on social media, where I go by @manonthemounjaro (or @manonmounjaro on X). Let's continue this journey together towards a healthier and happier life!

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Published 2024-04-09

On The Pen: The Weekly Dose 4.9.24

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Get the whole story at: https://www.onthepen.com

Bloomberg #ReleaseTheVials Feature:
https://www.bloomberg.com/news/articles/2024-04-02/zepbound-shortage-patients-push-eli-lilly-to-release-more-obesity-drug-supply

Yahoo Finanace #ReleaseTheVials Feature VIDEO: https://youtu.be/nQbYa47DF4Q?feature=shared

Yahoo Finance Catalent / Novo Deal Resubmission: https://finance.yahoo.com/news/novo-nordisk-parent-refiles-us-103118874.html

Bloomberg Lilly Germany Plant:
https://www.bloomberg.com/news/articles/2024-04-08/lilly-s-2-5-billion-german-plant-will-boost-obesity-drug-supply


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Published 2024-04-01

Zepbound Single Dose Vials Approved!

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In the largest move since approving Tirzepatide for chronic weight management in November of 2023, the FDA has posted the approval of a single-dose vial presentation of Zepbound. With the complexity of manufacturing the current single-dose pens, single dose vial presentations could prove to be an answer to increasing manufacturing shortages of Tirzepatide for both type 2 diabetes (Mounjaro) and chronic weight management (Zepbound). The FDA approved the single-dose vials of Mounjaro in July of 2023, but Eli Lilly has elected to offer that presentation in x-US markets only.

https://www.onthepen.com/post/zepbound-single-dose-vials-approved-by-fda

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📼 PLAYLISTS:
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Published 2024-03-26

On The Pen: The Weekly Dose 3/26/24

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All things VikingTide from Viking Therapeutics VK2735

https://ir.vikingtherapeutics.com/2024-03-26-Viking-Therapeutics-Announces-Results-from-Phase-1-Clinical-Trial-of-Oral-Tablet-Formulation-of-Dual-GLP-1-GIP-Receptor-Agonist-VK2735

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Published 2024-03-19

On The Pen: The Weekly Dose 3/19/24

16 min
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Amazon Remedies (affiliate links pay a commission that supports the channel):
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👉 Link to other GLP-1 MUST HAVE products I mention:
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📼 PLAYLISTS:
🖊️ ON THE PEN LIVES:
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😎 NERDS ONLY: LEARN ABOUT OTHER GLP-1 MEDS:
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🚨📰 ALL THE LATEST MOUNJARO NEWS:
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Send a text

Big news from Novo Nordisk and we have it all for you!! Cagrisema, high dose Semaglutide, new Amycretin, a triple angonist and more!

🎙️Weekly Podcast: https://podcasts.apple.com/us/podcast/on-the-pen-the-weekly-dose/id1725737068

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👀 WATCH MY MOUNJARO JOURNEY IN ORDER:
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Published 2024-03-05

On The Pen: The Weekly Dose 3/5/24

14 min
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This week Dave covers the latest in the Change Healthcare Hack, some interesting pubmed tirzepatide  data , and Oprah’s exit from the Weight Watchers board of directors.

Become a YouTube Community Member By Clicking Here:
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On The Pen Live Show (All Episodes In Order):
 https://www.youtube.com/playlist?list=PLtOcNl0C8quVdrWruYSrJpTZPF7jjXKfM

For Those Facing GLP-1 Access Issues:
Https://www.FlexFinance.Care
Tell them “Dave sent you” 😉

Zepbound FB Group:
https://www.facebook.com/share/oxMJXxuLTwczPpWq/?mibextid=K35XfP

SHOW LINKS
Change Healthcare Ransom Paid:
https://www.wired.com/story/alphv-change-healthcare-ransomware-payment/
Pubmed Asians vs. Non-Asians With DM2 Using Tirzepatide
https://pubmed.ncbi.nlm.nih.gov/38402331/
Oprah Leaving WW Board
https://www.thedailybeast.com/oprah-is-leaving-weightwatchers-after-revealing-weight-loss-drug-use
Dr. Michael Albert Interview:
https://youtu.be/nB9CXEsGNDc
The Big Shot Review
https://youtu.be/l-uyFOxqSYk

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📺 We're Live M/W/F at 11 central: onthepen.tv


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Thank you for tuning in! If you found this content valuable, make sure to like, share, and subscribe to my youtube channel for more updates on GLP-1, obesity, type 2 diabetes, and the latest news on Mounjaro, Zepbound, Wegovy, and Ozempic. Stay informed and entertained with my unique blend of breaking news, humor, and my personal journey. For in-depth articles and resources, visit onthepen.com.

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Dave Knapp (@ManOnTheMounjaro) joins Dr. Michael Albert, a leading voice in the obesity medicine, for a gripping conversation on the current and future state of obesity medicine.

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On The Pen Live Show (All Episodes In Order):
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For Those Facing GLP-1 Access Issues: 
Https://www.FlexFinance.Care
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Thank you for tuning in! If you found this content valuable, make sure to like, share, and subscribe to my youtube channel for more updates on GLP-1, obesity, type 2 diabetes, and the latest news on Mounjaro, Zepbound, Wegovy, and Ozempic. Stay informed and entertained with my unique blend of breaking news, humor, and my personal journey. For in-depth articles and resources, visit onthepen.com.

Published 2024-02-27

On The Pen: The Weekly Dose 2/27/24

15 min
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This week we cover:
- New readouts on the new Boehringer Ingleheim investigational med Survodutide. 
- Wegovy launches in Japan, and the - Change Healthcare cyber attack and how it’s effecting your prescription refills

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On The Pen Live Show (All Episodes In Order):
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SHOW LINKS
Survodutide Top Line Data: https://www.biospace.com/article/boehringer-s-obesity-candidate-shows-strong-potential-in-mash/
Wegovy in Japan: https://www3.nhk.or.jp/nhkworld/en/news/20240222_34/
Change Healthcare Hack: https://www.fastcompany.com/91037949/change-healthcare-cyber-attack-update-pharmacies-big-deal

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Thank you for tuning in! If you found this content valuable, make sure to like, share, and subscribe to my youtube channel for more updates on GLP-1, obesity, type 2 diabetes, and the latest news on Mounjaro, Zepbound, Wegovy, and Ozempic. Stay informed and entertained with my unique blend of breaking news, humor, and my personal journey. For in-depth articles and resources, visit onthepen.com.

Published 2024-02-20

On The Pen: The Weekly Dose 2/20/24

14 min
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Become a Community Member By Clicking Here:
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On The Pen Live Show (All Episodes In Order):
 https://www.youtube.com/playlist?list=PLtOcNl0C8quVdrWruYSrJpTZPF7jjXKfM

For Those Facing GLP-1 Access Issues: 
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Tell them “Dave sent you” 😉

Zepbound FB Group:
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SHOW LINKS
Number of people on glp-1
https://www.tipranks.com/news/weight-loss-drugs-are-slimming-down-grocery-bills

Morgan Stanley Sees Lilly as first 1T pharma stock
https://www.cnbc.com/2024/02/16/zepbound-could-propel-eli-lilly-to-become-the-first-1-trillion-pharma-stock.html

EU Kwik Pen Approval
https://www.reuters.com/business/healthcare-pharmaceuticals/eu-drug-regulator-review-lillys-mounjaro-multi-dose-pen-2024-02-19/

Gastric Bypass and  T2D
https://www.medicalnewstoday.com/articles/how-gastric-bypass-surgery-can-help-with-type-2-diabetes-remission

Unfilled GLP-1 Scripts:
https://www.iqvia.com/locations/united-states/blogs/2023/08/new-demand-in-an-old-market

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Thank you for tuning in! If you found this content valuable, make sure to like, share, and subscribe to my youtube channel for more updates on GLP-1, obesity, type 2 diabetes, and the latest news on Mounjaro, Zepbound, Wegovy, and Ozempic. Stay informed and entertained with my unique blend of breaking news, humor, and my personal journey. For in-depth articles and resources, visit onthepen.com.

Published 2024-02-13

Zepbound Mounjaro Ozempic News: 2.13.24

16 min
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Dive deep into the Novo Nordisk and Catalent merger and how that will affect the GLP-1 market.

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For Those Facing GLP-1 Access Issues: 
Https://www.FlexFinance.Care
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Thank you for watching my GLP-1 videos! If you found this content valuable, make sure to like, share, and subscribe to my channel for more updates on GLP-1, obesity, type 2 diabetes, and the latest news on Mounjaro, Zepbound, Wegovy, and Ozempic. Stay informed and entertained with my unique blend of breaking news, humor, and my personal journey. For in-depth articles and resources, visit my website at onthepen.com. You can also connect with me on social media, where I go by @manonthemounjaro (or @manonmounjaro on X). Let's continue this journey together towards a healthier and happier life!


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Thank you for tuning in! If you found this content valuable, make sure to like, share, and subscribe to my youtube channel for more updates on GLP-1, obesity, type 2 diabetes, and the latest news on Mounjaro, Zepbound, Wegovy, and Ozempic. Stay informed and entertained with my unique blend of breaking news, humor, and my personal journey. For in-depth articles and resources, visit onthepen.com.

Published 2024-02-07

Q4 Eli Lilly Earnings Call Recap

52 min
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Man on the Mounjaro Dave Knapp recxaps the 2023 Q4 ELi Lilly Earnings Call as it relates to obesity medicine.

Link To Earnings Call: https://investor.lilly.com/webcasts-and-presentations

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Thank you for watching my GLP-1 videos! If you found this content valuable, make sure to like, share, and subscribe to my channel for more updates on GLP-1, obesity, type 2 diabetes, and the latest news on Mounjaro, Zepbound, Wegovy, and Ozempic. Stay informed and entertained with my unique blend of breaking news, humor, and my personal journey. For in-depth articles and resources, visit my website at onthepen.com. You can also connect with me on social media, where I go by @manonthemounjaro (or @manonmounjaro on X). Let's continue this journey together towards a healthier and happier life!

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MY WORK RELIES ON YOUR GENEROSITY, WAYS TO SUPPORT:
Venmo: OnThePen
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WATCH MORE!
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Thank you for tuning in! If you found this content valuable, make sure to like, share, and subscribe to my youtube channel for more updates on GLP-1, obesity, type 2 diabetes, and the latest news on Mounjaro, Zepbound, Wegovy, and Ozempic. Stay informed and entertained with my unique blend of breaking news, humor, and my personal journey. For in-depth articles and resources, visit onthepen.com.

Published 2024-02-06

On The Pen: The Weekly Dose 2.6.24

13 min
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On The Pen Live Show (All Episodes In Order):
 https://www.youtube.com/playlist?list=PLtOcNl0C8quVdrWruYSrJpTZPF7jjXKfM

For Those Facing GLP-1 Access Issues: 
Https://www.FlexFinance.Care
Tell them “Dave sent you” 😉

Zepbound FB Group:
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News Links:
https://www.statnews.com/2024/02/05/amgen-obesity-drug-maintenance/

https://www.marketwatch.com/story/novo-nordisks-controlling-shareholder-to-buy-catalent-for-16-5-billion-7d57fcfc

https://www.reuters.com/business/healthcare-pharmaceuticals/abbott-launches-protein-shake-brand-help-people-weight-loss-drug-2024-01-31/?fbclid=IwAR3Zo6H3oFlv64aey7pOVQ-b25HoUeFBifBmuEkIjBVyEVN9hQB-aSr9o50_aem_AUWiG99wtAtBGejL31bUvjTvF0rBp16fchnVdcRcAgUVf5uHgLByYRhedO9eJrxbHe4

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MY WORK RELIES ON YOUR GENEROSITY, WAYS TO SUPPORT:
Venmo: OnThePen
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BECOME A MEMBER:
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Thank you for tuning in! If you found this content valuable, make sure to like, share, and subscribe to my youtube channel for more updates on GLP-1, obesity, type 2 diabetes, and the latest news on Mounjaro, Zepbound, Wegovy, and Ozempic. Stay informed and entertained with my unique blend of breaking news, humor, and my personal journey. For in-depth articles and resources, visit onthepen.com.

Published 2024-01-31

Q4 Novo Nordisk Earnings Call Recap

25 min
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In this special edition of the weekly dose podcast, Dave knapp covers the recent fourth-quarter earnings call from Novo Nordisk. What does this mean for users of Ozempic Wegovy?

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Https://www.zennutrients.com/mounjaroman
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#elililly #novonordisk #ozempic #wegovy #zepbound #onthepen #manonthemounjaro #semaglutide #liraglutide #saxenda #victoza #obesitymedicine #elililly #novonordisk #diabetes #diabesity #trulicity

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MY WORK RELIES ON YOUR GENEROSITY, WAYS TO SUPPORT:
Venmo: OnThePen
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BECOME A MEMBER:
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WATCH MORE!
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Thank you for tuning in! If you found this content valuable, make sure to like, share, and subscribe to my youtube channel for more updates on GLP-1, obesity, type 2 diabetes, and the latest news on Mounjaro, Zepbound, Wegovy, and Ozempic. Stay informed and entertained with my unique blend of breaking news, humor, and my personal journey. For in-depth articles and resources, visit onthepen.com.

Published 2024-01-30

On The Pen: The Weekly Dose 1.30.24

14 min
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On The Pen Live Show (All Episodes In Order):
 https://www.youtube.com/playlist?list=PLtOcNl0C8quVdrWruYSrJpTZPF7jjXKfM

For Those Facing GLP-1 Access Issues:
Https://www.FlexFinance.Care
Tell them “Dave sent you” 😉

Zepbound FB Group:
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News Links:

https://www.accessdata.fda.gov/scripts/drugshortages/dsp_ActiveIngredientDetails.cfm?AI=Tirzepatide%20Injection&st=c

https://www.fiercebiotech.com/biotech/novo-nordisk-puts-255m-line-bag-another-obesity-asset-turning-eracal-novel-approachhttps://fortune.com/2024/01/27/north-carolina-drops-coverage-for-wegovy-and-ozempic-weight-loss-drugs/amp/

https://www.reuters.com/business/healthcare-pharmaceuticals/british-regulator-clears-lillys-injection-pen-weight-loss-drug-mounjaro-2024-01-25/

https://futurism.com/neoscope/study-contradicts-weight-stop-ozempic-semaglutide



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MY WORK RELIES ON YOUR GENEROSITY, WAYS TO SUPPORT:
Venmo: OnThePen
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BECOME A MEMBER:
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Thank you for tuning in! If you found this content valuable, make sure to like, share, and subscribe to my youtube channel for more updates on GLP-1, obesity, type 2 diabetes, and the latest news on Mounjaro, Zepbound, Wegovy, and Ozempic. Stay informed and entertained with my unique blend of breaking news, humor, and my personal journey. For in-depth articles and resources, visit onthepen.com.

Published 2024-01-23

On The Pen: The Weekly Dose 1.23.24

16 min
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Weekly dose of Mounjaro Zepbound Wegovy Ozempic news!

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On The Pen Live Show (All Episodes In Order):
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PeptideVite GLP-1 Suppliment: 
zennutrients.com/mounjaroman
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Zepbound FB Group:
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Follow My Switch To Ozempic Chronologically: 
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NEWS LINKS:

https://www.cnbc.com/amp/2024/01/17/weight-loss-drugs-boehringer-ingelheim-terns-viking-may-join-market.html

https://www.fiercepharma.com/marketing/novo-nordisk-having-paused-dampen-demand-resumes-wegovy-obesity-promotion-new-tv-ad

https://www.fiercebiotech.com/research/glp-1-drug-hydrogels-could-reduce-shots-once-every-4-months

https://www.yahoo.com/lifestyle/states-top-users-ozempic-wegovy-201526426.html

https://www.wsj.com/health/pharma/obesity-drugs-lead-to-muscle-losspharma-companies-want-to-fix-that-f2f5fe45#selection-9544.2-9586.0


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Thank you for tuning in! If you found this content valuable, make sure to like, share, and subscribe to my youtube channel for more updates on GLP-1, obesity, type 2 diabetes, and the latest news on Mounjaro, Zepbound, Wegovy, and Ozempic. Stay informed and entertained with my unique blend of breaking news, humor, and my personal journey. For in-depth articles and resources, visit onthepen.com.

Published 2024-01-16

On The Pen: The Weekly Dose 1.16.24

14 min
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Popular Compound Pharmacy Closes: https://www.washingtonpost.com/business/2024/01/15/aca-pharmacy-weight-loss-drugs

Ozempic Lawsuits
https://nypost.com/2024/01/13/lifestyle/woman-suffers-life-threatening-bowel-injury-from-ozempic-suit/

FDA: Ozempic Doesn't Increase Suicide Risk
https://news.yahoo.com/wegovy-ozempic-seem-less-dangerous-195000154.html

Ozempic 1.7 back in stock
https://www.reuters.com/business/healthcare-pharmaceuticals/novo-nordisk-resumes-shipments-wegovy-17-mg-dose-us-2024-01-12/

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PeptideVite GLP-1 Suppliment:
zennutrients.com/mounjaroman
10% OFF CODE: DAVIDK

Zepbound FB Group:
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MY WORK RELIES ON YOUR GENEROSITY, WAYS TO SUPPORT:
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Thank you for tuning in! If you found this content valuable, make sure to like, share, and subscribe to my youtube channel for more updates on GLP-1, obesity, type 2 diabetes, and the latest news on Mounjaro, Zepbound, Wegovy, and Ozempic. Stay informed and entertained with my unique blend of breaking news, humor, and my personal journey. For in-depth articles and resources, visit onthepen.com.

Published 2024-01-14

On The Pen: The Weekly Dose Podcast!

1 min
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Here's what to expect from The Weekly Dose Podcast from On The Pen!

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